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Trial details imported from ClinicalTrials.gov
For full trial details, please see the original record at
https://clinicaltrials.gov/study/NCT00391872
Registration number
NCT00391872
Ethics application status
Date submitted
23/10/2006
Date registered
25/10/2006
Date last updated
13/03/2012
Titles & IDs
Public title
A Comparison of Ticagrelor (AZD6140) and Clopidogrel in Patients With Acute Coronary Syndrome
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Scientific title
A Randomised, Double-blind, Parallel Group, Phase 3, Efficacy and Safety Study of Ticagrelor Compared With Clopidogrel for Prevention of Vascular Events in Patients With Non-ST or ST Elevation Acute Coronary Syndromes (ACS) [PLATO- a Study of PLATelet Inhibition and Patient Outcomes]
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Secondary ID [1]
0
0
PLATO
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Secondary ID [2]
0
0
D5130C05262
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Universal Trial Number (UTN)
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Trial acronym
PLATO
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Linked study record
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Health condition
Health condition(s) or problem(s) studied:
Acute Coronary Syndrome
0
0
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Condition category
Condition code
Cardiovascular
0
0
0
0
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Coronary heart disease
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Other
0
0
0
0
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Research that is not of generic health relevance and not applicable to specific health categories listed above
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Intervention/exposure
Study type
Interventional
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Description of intervention(s) / exposure
Treatment: Drugs - Ticagrelor
Treatment: Drugs - Clopidogrel
Active comparator: Clopidogrel - Oral treatment
Experimental: Ticagrelor - Oral treatment
Treatment: Drugs: Ticagrelor
Ticagrelor (AZD6140) 90 mg twice daily dose (BD)
Treatment: Drugs: Clopidogrel
Clopidogrel 75 mg once daily dose (ODD)
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Intervention code [1]
0
0
Treatment: Drugs
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Comparator / control treatment
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Control group
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Outcomes
Primary outcome [1]
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0
Participants With Any Event From the Composite of Death From Vascular Causes, Myocardial Infarction (MI), and Stroke
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Assessment method [1]
0
0
Participants with death from vascular causes, MI, or stroke. If no event, censoring occurs at the earliest of patient withdrawal consent or date of scheduled withdrawal from therapy. Intention To Treat (ITT) analysis of whole population. Events were adjudicated by an endpoint committee.
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Timepoint [1]
0
0
Randomization up to 12 months
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Primary outcome [2]
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0
Participants With Any Major Bleeding Event
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Assessment method [2]
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0
Participants with major (fatal/life-threatening or other) bleed by a study protocol scale based on need for treatment, number of transfusions, hemoglobin decrease, and other factors. Events were adjudicated by an endpoint committee.
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Timepoint [2]
0
0
First dosing up to 12 months
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Secondary outcome [1]
0
0
Participants With Any Event From the Composite of Death From Vascular Causes, MI, and Stroke for the Subgroup of Patients With Intent for Invasive Management at Randomization
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Assessment method [1]
0
0
Participants with death from vascular causes, MI, or stroke. If no event, censoring occurs at the earliest of patient withdrawal consent or date of scheduled withdrawal from therapy. ITT analysis of intent for invasive management population. Events were adjudicated by an endpoint committee.
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Timepoint [1]
0
0
Randomization up to 12 months
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Secondary outcome [2]
0
0
Participants With Any Event From the Composite of All-cause Mortality, MI, and Stroke
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Assessment method [2]
0
0
Participants with death from any cause, MI, or stroke. If no event, censoring occurs at the earliest of patient withdrawal of consent or date of scheduled withdrawal from therapy. ITT analysis of whole population. Events were adjudicated by an endpoint committee.
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Timepoint [2]
0
0
Randomization up to 12 months
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Secondary outcome [3]
0
0
Participants With Any Event From the Composite of Death From Vascular Causes, MI (Including Silent), Stroke, Recurrent Ischemia, Transient Ischemic Attack (TIA) and Other Arterial Thrombotic Events.
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Assessment method [3]
0
0
Participants with death from vascular causes, MI, stroke, recurrent ischemia, or other thrombotic events. If no event, censoring occurs at the earliest of patient withdrawal consent or date of scheduled withdrawal from therapy. ITT analysis of whole population. Events were adjudicated.
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Timepoint [3]
0
0
Randomization up to 12 months
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Secondary outcome [4]
0
0
Participants With MI Event
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Assessment method [4]
0
0
Participants with MI event. If no event, censoring occurs at the earliest of patient withdrawal consent or date of scheduled withdrawal from therapy. ITT (intention to treat) analysis of whole population. Events were adjudicated by an endpoint committee.
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Timepoint [4]
0
0
Randomization up to 12 months
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Secondary outcome [5]
0
0
Participants With Death From Vascular Causes
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Assessment method [5]
0
0
Participants with death from vascular causes. If no event, censoring occurs at the earliest of patient withdrawal consent or date of scheduled withdrawal from therapy. ITT (intention to treat) analysis of whole population. Events were adjudicated by an endpoint committee.
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Timepoint [5]
0
0
Randomization up to 12 months
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Secondary outcome [6]
0
0
Participants With Stroke
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Assessment method [6]
0
0
Participants with stroke. If no event, censoring occurs at the earliest of patient withdrawal consent or date of scheduled withdrawal from therapy. ITT (intention to treat) analysis of whole population. Events were adjudicated by an endpoint committee.
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Timepoint [6]
0
0
Randomization up to 12 months
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Secondary outcome [7]
0
0
Participants With Death From Any Cause
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Assessment method [7]
0
0
Participants with death from any cause. If no event, censoring occurs at the earliest of patient withdrawal consent or date of scheduled withdrawal from therapy. ITT (intention to treat) analysis of whole population. Events were adjudicated by an endpoint committee.
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Timepoint [7]
0
0
Randomization up to 12 months
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Secondary outcome [8]
0
0
Participants With Non-CABG (Coronary Artery Bypass Graft) Related Major Bleeding
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Assessment method [8]
0
0
Participants with non CABG related major (fatal/life-threatening or other) bleed by a study protocol scale based on need for treatment, number of transfusions, hemoglobin decrease, and other factors. Events were adjudicated by an endpoint committee.
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Timepoint [8]
0
0
First dosing up to 12 months
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Secondary outcome [9]
0
0
Participants With Major or Minor Bleeding
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Assessment method [9]
0
0
Participants with major (fatal/life-threatening or other) or minor bleed by a study protocol scale based on need for treatment, number of transfusions, hemoglobin decrease, and other factors. Events were adjudicated by an endpoint committee.
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Timepoint [9]
0
0
First dosing up to 12 months
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Secondary outcome [10]
0
0
Participants With Non-procedural Major Bleeding
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Assessment method [10]
0
0
Participants with non-procedural major bleed by a study protocol scale based on need for treatment, number of transfusions, hemoglobin decrease, and other factors. Events were adjudicated by an endpoint committee.
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Timepoint [10]
0
0
First dosing up to 12 months
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Secondary outcome [11]
0
0
Participants With Coronary Artery Bypass Graft (CABG) Major Bleeding
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Assessment method [11]
0
0
Participants with a major CABG-related bleed by a study protocol scale based on need for treatment, number of transfusions, hemoglobin decrease, and other factors. All CABG surgeries were submitted for adjudication by an endpoint committee as potential bleeds.
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Timepoint [11]
0
0
First dosing up to 12 months
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Secondary outcome [12]
0
0
Participants With Coronary Artery Bypass Graft (CABG) Major Fatal/Life-threatening Bleeding
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Assessment method [12]
0
0
Number of participants with a major fatal/life-threatening CABG-related bleed by a study protocol scale based on need for treatment, number of transfusions, hemoglobin decrease, and other factors. All CABG surgeries were submitted for adjudication by an endpoint committee as potential bleeds.
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Timepoint [12]
0
0
First dosing up to 12 months
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Secondary outcome [13]
0
0
Participants With Ventricular Pauses of Greater Than or Equal to 3 Seconds in Patients Monitored by Holter 24-hour ECG Recorders for 1 Week Following Randomization
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Assessment method [13]
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0
Number of participants who were observed to have at least 1 ventricular pause of at least 3 seconds. Population is all patients who were observed over 2 week-long periods. Pauses were flagged algorithmically and confirmed by Thrombolysis in Myocardial Infarction (TIMI) group cardiologists.
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Timepoint [13]
0
0
1-week period following randomization
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Secondary outcome [14]
0
0
Participants With Ventricular Pauses of Greater Than or Equal to 3 Seconds in Patients Monitored by Holter 24 Hour ECG Recorders for 1 Week at 1 Month Following Randomization
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Assessment method [14]
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Number of participants who were observed to have at least 1 ventricular pause of at least 3 seconds. Population is all patients who were observed over 2 week-long periods. Pauses were flagged algorithmically and confirmed by TIMI cardiologists.
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Timepoint [14]
0
0
1-week period following randomization
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Eligibility
Key inclusion criteria
* Male or female 18 years or older who has been hospitalised for chest pain and potential ACS
* Females of child-bearing potential must have a negative pregnancy test at enrollment and be willing to use 2 methods of reliable contraception
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Minimum age
18
Years
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Maximum age
No limit
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Sex
Both males and females
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Can healthy volunteers participate?
No
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Key exclusion criteria
* Persons with moderate or severe liver disease
* Persons who have already been treated with an invasive (angioplasty) procedure for the current episode of ACS
* Persons who are being treated with blood clotting agents that cannot be stopped
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Study design
Purpose of the study
Treatment
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Allocation to intervention
Randomised controlled trial
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Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures)
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Methods used to generate the sequence in which subjects will be randomised (sequence generation)
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Masking / blinding
Blinded (masking used)
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Who is / are masked / blinded?
The people receiving the treatment/s
The people administering the treatment/s
The people assessing the outcomes
The people analysing the results/data
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Intervention assignment
Parallel
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Other design features
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Phase
Phase 3
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Type of endpoint/s
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Statistical methods / analysis
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Recruitment
Recruitment status
Completed
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Data analysis
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Reason for early stopping/withdrawal
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Other reasons
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Date of first participant enrolment
Anticipated
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Actual
1/10/2006
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Date of last participant enrolment
Anticipated
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Actual
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Date of last data collection
Anticipated
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Actual
1/03/2009
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Sample size
Target
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Accrual to date
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Final
18624
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Recruitment in Australia
Recruitment state(s)
ACT,QLD,SA,VIC,WA
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Recruitment hospital [1]
0
0
Research Site - Bruce
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Recruitment hospital [2]
0
0
Research Site - Chermside
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Recruitment hospital [3]
0
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Research Site - Herston
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Recruitment hospital [4]
0
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Research Site - Woolloongabba
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Recruitment hospital [5]
0
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Research Site - Bedford Park
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Recruitment hospital [6]
0
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Research Site - Dandenong
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Recruitment hospital [7]
0
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Research Site - Geelong
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Recruitment hospital [8]
0
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Research Site - Melbourne
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Recruitment hospital [9]
0
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Research Site - Perth
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Recruitment postcode(s) [1]
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0
- Bruce
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Recruitment postcode(s) [2]
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- Chermside
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Recruitment postcode(s) [3]
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- Herston
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Recruitment postcode(s) [4]
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- Woolloongabba
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Recruitment postcode(s) [5]
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- Bedford Park
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Recruitment postcode(s) [6]
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- Dandenong
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Recruitment postcode(s) [7]
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- Geelong
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Recruitment postcode(s) [8]
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- Melbourne
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Recruitment postcode(s) [9]
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- Perth
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Recruitment outside Australia
Country [1]
0
0
United States of America
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State/province [1]
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Alabama
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United States of America
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Arizona
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United States of America
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California
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United States of America
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Colorado
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United States of America
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Connecticut
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United States of America
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Delaware
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United States of America
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District of Columbia
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United States of America
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Florida
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United States of America
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Illinois
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United States of America
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Indiana
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United States of America
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Iowa
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Kansas
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Kentucky
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Louisiana
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Maine
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Maryland
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Minnesota
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Mississippi
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Missouri
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Argentina
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Buenos Aires
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Argentina
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Pcia. de Buenos Aires
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Argentina
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Argentina
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Austria
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Feldkirch
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Aalst
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Charleroi
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Edegem
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Genk
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Wilrijk
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Brazil
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AL
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Brazil
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BA
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Brazil
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DF
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Brazil
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GO
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Brazil
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MG
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Brazil
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MS
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Brazil
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PE
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Brazil
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PR
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Brazil
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RJ
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Brazil
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RS
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Brazil
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SC
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Brazil
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SE
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Brazil
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SP
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Brazil
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Campinas
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Burgas
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Dimitrovgrad
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Gabrovo
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Haskovo
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Bulgaria
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Pleven
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0
0
Smolian
Query!
Country [95]
0
0
Bulgaria
Query!
State/province [95]
0
0
Sofia
Query!
Country [96]
0
0
Bulgaria
Query!
State/province [96]
0
0
Varna
Query!
Country [97]
0
0
Canada
Query!
State/province [97]
0
0
Alberta
Query!
Country [98]
0
0
Canada
Query!
State/province [98]
0
0
British Columbia
Query!
Country [99]
0
0
Canada
Query!
State/province [99]
0
0
Manitoba
Query!
Country [100]
0
0
Canada
Query!
State/province [100]
0
0
New Brunswick
Query!
Country [101]
0
0
Canada
Query!
State/province [101]
0
0
Newfoundland and Labrador
Query!
Country [102]
0
0
Canada
Query!
State/province [102]
0
0
Ontario
Query!
Country [103]
0
0
Canada
Query!
State/province [103]
0
0
Quebec
Query!
Country [104]
0
0
Canada
Query!
State/province [104]
0
0
Saskatchewan
Query!
Country [105]
0
0
China
Query!
State/province [105]
0
0
Guangdong
Query!
Country [106]
0
0
China
Query!
State/province [106]
0
0
Liaoning
Query!
Country [107]
0
0
China
Query!
State/province [107]
0
0
Sichuan
Query!
Country [108]
0
0
China
Query!
State/province [108]
0
0
Beijing
Query!
Country [109]
0
0
China
Query!
State/province [109]
0
0
Hang Zhou
Query!
Country [110]
0
0
China
Query!
State/province [110]
0
0
Shanghai, Pudong
Query!
Country [111]
0
0
Czech Republic
Query!
State/province [111]
0
0
CZ
Query!
Country [112]
0
0
Czech Republic
Query!
State/province [112]
0
0
Hradec Kralove
Query!
Country [113]
0
0
Czech Republic
Query!
State/province [113]
0
0
Jihlava
Query!
Country [114]
0
0
Czech Republic
Query!
State/province [114]
0
0
Kladno
Query!
Country [115]
0
0
Czech Republic
Query!
State/province [115]
0
0
Liberec
Query!
Country [116]
0
0
Czech Republic
Query!
State/province [116]
0
0
Olomouc
Query!
Country [117]
0
0
Czech Republic
Query!
State/province [117]
0
0
Ostrava-poruba
Query!
Country [118]
0
0
Czech Republic
Query!
State/province [118]
0
0
Pardubice
Query!
Country [119]
0
0
Czech Republic
Query!
State/province [119]
0
0
Praha
Query!
Country [120]
0
0
Czech Republic
Query!
State/province [120]
0
0
Slany
Query!
Country [121]
0
0
Czech Republic
Query!
State/province [121]
0
0
Teplice
Query!
Country [122]
0
0
Czech Republic
Query!
State/province [122]
0
0
Usti Nad Labem
Query!
Country [123]
0
0
Czech Republic
Query!
State/province [123]
0
0
Usti Nad Orlici
Query!
Country [124]
0
0
Czech Republic
Query!
State/province [124]
0
0
Zlin
Query!
Country [125]
0
0
Czech Republic
Query!
State/province [125]
0
0
Znojmo
Query!
Country [126]
0
0
Denmark
Query!
State/province [126]
0
0
Esbjerg
Query!
Country [127]
0
0
Denmark
Query!
State/province [127]
0
0
Fredericia
Query!
Country [128]
0
0
Denmark
Query!
State/province [128]
0
0
Frederiksberg
Query!
Country [129]
0
0
Denmark
Query!
State/province [129]
0
0
Frederikssund
Query!
Country [130]
0
0
Denmark
Query!
State/province [130]
0
0
Glostrup
Query!
Country [131]
0
0
Denmark
Query!
State/province [131]
0
0
Hellerup
Query!
Country [132]
0
0
Denmark
Query!
State/province [132]
0
0
Herlev
Query!
Country [133]
0
0
Denmark
Query!
State/province [133]
0
0
Herning
Query!
Country [134]
0
0
Denmark
Query!
State/province [134]
0
0
Hillerod
Query!
Country [135]
0
0
Denmark
Query!
State/province [135]
0
0
Hjorring
Query!
Country [136]
0
0
Denmark
Query!
State/province [136]
0
0
Holbaek
Query!
Country [137]
0
0
Denmark
Query!
State/province [137]
0
0
Horsens
Query!
Country [138]
0
0
Denmark
Query!
State/province [138]
0
0
Hvidovre
Query!
Country [139]
0
0
Denmark
Query!
State/province [139]
0
0
Kobenhavn
Query!
Country [140]
0
0
Denmark
Query!
State/province [140]
0
0
Koge
Query!
Country [141]
0
0
Denmark
Query!
State/province [141]
0
0
Kolding
Query!
Country [142]
0
0
Denmark
Query!
State/province [142]
0
0
Naestved
Query!
Country [143]
0
0
Denmark
Query!
State/province [143]
0
0
Odense C
Query!
Country [144]
0
0
Denmark
Query!
State/province [144]
0
0
Roskilde
Query!
Country [145]
0
0
Denmark
Query!
State/province [145]
0
0
Silkeborg
Query!
Country [146]
0
0
Denmark
Query!
State/province [146]
0
0
Slagelse
Query!
Country [147]
0
0
Denmark
Query!
State/province [147]
0
0
Viborg
Query!
Country [148]
0
0
Finland
Query!
State/province [148]
0
0
Hus (helsinki)
Query!
Country [149]
0
0
Finland
Query!
State/province [149]
0
0
Jyvaskyla
Query!
Country [150]
0
0
Finland
Query!
State/province [150]
0
0
Kokkola
Query!
Country [151]
0
0
Finland
Query!
State/province [151]
0
0
Kuopio
Query!
Country [152]
0
0
Finland
Query!
State/province [152]
0
0
Lahti
Query!
Country [153]
0
0
Finland
Query!
State/province [153]
0
0
Lappeenranta
Query!
Country [154]
0
0
Finland
Query!
State/province [154]
0
0
Pori
Query!
Country [155]
0
0
Finland
Query!
State/province [155]
0
0
Rovaniemi
Query!
Country [156]
0
0
Finland
Query!
State/province [156]
0
0
Turku
Query!
Country [157]
0
0
France
Query!
State/province [157]
0
0
Abbeville
Query!
Country [158]
0
0
France
Query!
State/province [158]
0
0
Allauch
Query!
Country [159]
0
0
France
Query!
State/province [159]
0
0
Arras
Query!
Country [160]
0
0
France
Query!
State/province [160]
0
0
Avignon
Query!
Country [161]
0
0
France
Query!
State/province [161]
0
0
Bayonne
Query!
Country [162]
0
0
France
Query!
State/province [162]
0
0
Besancon
Query!
Country [163]
0
0
France
Query!
State/province [163]
0
0
Brest
Query!
Country [164]
0
0
France
Query!
State/province [164]
0
0
Caen
Query!
Country [165]
0
0
France
Query!
State/province [165]
0
0
Cholet
Query!
Country [166]
0
0
France
Query!
State/province [166]
0
0
Creteil
Query!
Country [167]
0
0
France
Query!
State/province [167]
0
0
Croix
Query!
Country [168]
0
0
France
Query!
State/province [168]
0
0
Dijon
Query!
Country [169]
0
0
France
Query!
State/province [169]
0
0
Douai
Query!
Country [170]
0
0
France
Query!
State/province [170]
0
0
Falaise
Query!
Country [171]
0
0
France
Query!
State/province [171]
0
0
Frejus
Query!
Country [172]
0
0
France
Query!
State/province [172]
0
0
La Rochelle
Query!
Country [173]
0
0
France
Query!
State/province [173]
0
0
Lagny Sur Marne
Query!
Country [174]
0
0
France
Query!
State/province [174]
0
0
Lille
Query!
Country [175]
0
0
France
Query!
State/province [175]
0
0
Limoges
Query!
Country [176]
0
0
France
Query!
State/province [176]
0
0
Lomme
Query!
Country [177]
0
0
France
Query!
State/province [177]
0
0
Marseille
Query!
Country [178]
0
0
France
Query!
State/province [178]
0
0
Nimes
Query!
Country [179]
0
0
France
Query!
State/province [179]
0
0
Orleans
Query!
Country [180]
0
0
France
Query!
State/province [180]
0
0
Paris
Query!
Country [181]
0
0
France
Query!
State/province [181]
0
0
PAU
Query!
Country [182]
0
0
France
Query!
State/province [182]
0
0
Pessac
Query!
Country [183]
0
0
France
Query!
State/province [183]
0
0
Quincy Sous Senart
Query!
Country [184]
0
0
France
Query!
State/province [184]
0
0
Rennes
Query!
Country [185]
0
0
France
Query!
State/province [185]
0
0
Rouen
Query!
Country [186]
0
0
France
Query!
State/province [186]
0
0
Senlis
Query!
Country [187]
0
0
France
Query!
State/province [187]
0
0
Strasbourg
Query!
Country [188]
0
0
France
Query!
State/province [188]
0
0
Toulouse
Query!
Country [189]
0
0
France
Query!
State/province [189]
0
0
Tourcoing
Query!
Country [190]
0
0
France
Query!
State/province [190]
0
0
Valenciennes
Query!
Country [191]
0
0
Georgia
Query!
State/province [191]
0
0
Tbilisi
Query!
Country [192]
0
0
Germany
Query!
State/province [192]
0
0
Aschaffenburg
Query!
Country [193]
0
0
Germany
Query!
State/province [193]
0
0
Bad Mergentheim
Query!
Country [194]
0
0
Germany
Query!
State/province [194]
0
0
Bad Nauheim
Query!
Country [195]
0
0
Germany
Query!
State/province [195]
0
0
Bad Rothenfelde
Query!
Country [196]
0
0
Germany
Query!
State/province [196]
0
0
Berlin
Query!
Country [197]
0
0
Germany
Query!
State/province [197]
0
0
Bochum
Query!
Country [198]
0
0
Germany
Query!
State/province [198]
0
0
Bonn
Query!
Country [199]
0
0
Germany
Query!
State/province [199]
0
0
Cloppenburg
Query!
Country [200]
0
0
Germany
Query!
State/province [200]
0
0
Coburg
Query!
Country [201]
0
0
Germany
Query!
State/province [201]
0
0
Dortmund
Query!
Country [202]
0
0
Germany
Query!
State/province [202]
0
0
Dresden
Query!
Country [203]
0
0
Germany
Query!
State/province [203]
0
0
Duisburg
Query!
Country [204]
0
0
Germany
Query!
State/province [204]
0
0
Erfurt
Query!
Country [205]
0
0
Germany
Query!
State/province [205]
0
0
Essen
Query!
Country [206]
0
0
Germany
Query!
State/province [206]
0
0
Esslingen
Query!
Country [207]
0
0
Germany
Query!
State/province [207]
0
0
Frankfurt
Query!
Country [208]
0
0
Germany
Query!
State/province [208]
0
0
Gottingen
Query!
Country [209]
0
0
Germany
Query!
State/province [209]
0
0
Greifswald
Query!
Country [210]
0
0
Germany
Query!
State/province [210]
0
0
Halle
Query!
Country [211]
0
0
Germany
Query!
State/province [211]
0
0
Hamburg
Query!
Country [212]
0
0
Germany
Query!
State/province [212]
0
0
Hannover
Query!
Country [213]
0
0
Germany
Query!
State/province [213]
0
0
Heidelberg
Query!
Country [214]
0
0
Germany
Query!
State/province [214]
0
0
Jena
Query!
Country [215]
0
0
Germany
Query!
State/province [215]
0
0
Kiel
Query!
Country [216]
0
0
Germany
Query!
State/province [216]
0
0
Krefeld
Query!
Country [217]
0
0
Germany
Query!
State/province [217]
0
0
Limburg
Query!
Country [218]
0
0
Germany
Query!
State/province [218]
0
0
Lubeck
Query!
Country [219]
0
0
Germany
Query!
State/province [219]
0
0
Mainz
Query!
Country [220]
0
0
Germany
Query!
State/province [220]
0
0
Merseburg
Query!
Country [221]
0
0
Germany
Query!
State/province [221]
0
0
Monchengladbach
Query!
Country [222]
0
0
Germany
Query!
State/province [222]
0
0
Muhlheim An Der Ruhr
Query!
Country [223]
0
0
Germany
Query!
State/province [223]
0
0
Munster
Query!
Country [224]
0
0
Germany
Query!
State/province [224]
0
0
Regensburg
Query!
Country [225]
0
0
Germany
Query!
State/province [225]
0
0
Rostock
Query!
Country [226]
0
0
Germany
Query!
State/province [226]
0
0
ULM
Query!
Country [227]
0
0
Germany
Query!
State/province [227]
0
0
Warendorf
Query!
Country [228]
0
0
Germany
Query!
State/province [228]
0
0
Witten
Query!
Country [229]
0
0
Germany
Query!
State/province [229]
0
0
Wuppertal
Query!
Country [230]
0
0
Germany
Query!
State/province [230]
0
0
Wurzburg
Query!
Country [231]
0
0
Greece
Query!
State/province [231]
0
0
Crete
Query!
Country [232]
0
0
Greece
Query!
State/province [232]
0
0
Athens
Query!
Country [233]
0
0
Greece
Query!
State/province [233]
0
0
Larissa
Query!
Country [234]
0
0
Greece
Query!
State/province [234]
0
0
Patra
Query!
Country [235]
0
0
Greece
Query!
State/province [235]
0
0
Piraeus
Query!
Country [236]
0
0
Greece
Query!
State/province [236]
0
0
Thessaloniki
Query!
Country [237]
0
0
Hong Kong
Query!
State/province [237]
0
0
Hong Kong
Query!
Country [238]
0
0
Hungary
Query!
State/province [238]
0
0
Budapest
Query!
Country [239]
0
0
Hungary
Query!
State/province [239]
0
0
Cegled
Query!
Country [240]
0
0
Hungary
Query!
State/province [240]
0
0
Debrecen
Query!
Country [241]
0
0
Hungary
Query!
State/province [241]
0
0
Gyula
Query!
Country [242]
0
0
Hungary
Query!
State/province [242]
0
0
Hodmez-vasarhely
Query!
Country [243]
0
0
Hungary
Query!
State/province [243]
0
0
Kaposvar
Query!
Country [244]
0
0
Hungary
Query!
State/province [244]
0
0
Kecskemet
Query!
Country [245]
0
0
Hungary
Query!
State/province [245]
0
0
Mosonmagyarovar
Query!
Country [246]
0
0
Hungary
Query!
State/province [246]
0
0
Pecs
Query!
Country [247]
0
0
Hungary
Query!
State/province [247]
0
0
Szekesfehervar
Query!
Country [248]
0
0
Hungary
Query!
State/province [248]
0
0
Zalaegerszeg
Query!
Country [249]
0
0
India
Query!
State/province [249]
0
0
Andhrapradesh
Query!
Country [250]
0
0
India
Query!
State/province [250]
0
0
Delhi
Query!
Country [251]
0
0
India
Query!
State/province [251]
0
0
Gujarat
Query!
Country [252]
0
0
India
Query!
State/province [252]
0
0
Karnataka
Query!
Country [253]
0
0
India
Query!
State/province [253]
0
0
Kerala
Query!
Country [254]
0
0
India
Query!
State/province [254]
0
0
Madhya Pradesh
Query!
Country [255]
0
0
India
Query!
State/province [255]
0
0
Maharashtra
Query!
Country [256]
0
0
India
Query!
State/province [256]
0
0
Punjab
Query!
Country [257]
0
0
India
Query!
State/province [257]
0
0
Rajasthan
Query!
Country [258]
0
0
India
Query!
State/province [258]
0
0
Tamilnadu
Query!
Country [259]
0
0
India
Query!
State/province [259]
0
0
West Bengal
Query!
Country [260]
0
0
Indonesia
Query!
State/province [260]
0
0
Bali
Query!
Country [261]
0
0
Indonesia
Query!
State/province [261]
0
0
Jawa Barat
Query!
Country [262]
0
0
Indonesia
Query!
State/province [262]
0
0
Jawa Timur
Query!
Country [263]
0
0
Indonesia
Query!
State/province [263]
0
0
Jakarta
Query!
Country [264]
0
0
Indonesia
Query!
State/province [264]
0
0
Makassar
Query!
Country [265]
0
0
Indonesia
Query!
State/province [265]
0
0
Semarang
Query!
Country [266]
0
0
Israel
Query!
State/province [266]
0
0
Afula
Query!
Country [267]
0
0
Israel
Query!
State/province [267]
0
0
Ashkelon
Query!
Country [268]
0
0
Israel
Query!
State/province [268]
0
0
Beer Sheva
Query!
Country [269]
0
0
Israel
Query!
State/province [269]
0
0
Hadera
Query!
Country [270]
0
0
Israel
Query!
State/province [270]
0
0
Haifa
Query!
Country [271]
0
0
Israel
Query!
State/province [271]
0
0
Holon
Query!
Country [272]
0
0
Israel
Query!
State/province [272]
0
0
Jerusalem
Query!
Country [273]
0
0
Israel
Query!
State/province [273]
0
0
Poriya M.p. Lower Galilee
Query!
Country [274]
0
0
Israel
Query!
State/province [274]
0
0
Rehovot
Query!
Country [275]
0
0
Israel
Query!
State/province [275]
0
0
Tel Aviv
Query!
Country [276]
0
0
Israel
Query!
State/province [276]
0
0
Zerifin
Query!
Country [277]
0
0
Italy
Query!
State/province [277]
0
0
AN
Query!
Country [278]
0
0
Italy
Query!
State/province [278]
0
0
BA
Query!
Country [279]
0
0
Italy
Query!
State/province [279]
0
0
BG
Query!
Country [280]
0
0
Italy
Query!
State/province [280]
0
0
CE
Query!
Country [281]
0
0
Italy
Query!
State/province [281]
0
0
CT
Query!
Country [282]
0
0
Italy
Query!
State/province [282]
0
0
FE
Query!
Country [283]
0
0
Italy
Query!
State/province [283]
0
0
FG
Query!
Country [284]
0
0
Italy
Query!
State/province [284]
0
0
FI
Query!
Country [285]
0
0
Italy
Query!
State/province [285]
0
0
MI
Query!
Country [286]
0
0
Italy
Query!
State/province [286]
0
0
MN
Query!
Country [287]
0
0
Italy
Query!
State/province [287]
0
0
MO
Query!
Country [288]
0
0
Italy
Query!
State/province [288]
0
0
PE
Query!
Country [289]
0
0
Italy
Query!
State/province [289]
0
0
PR
Query!
Country [290]
0
0
Italy
Query!
State/province [290]
0
0
PV
Query!
Country [291]
0
0
Italy
Query!
State/province [291]
0
0
Roma
Query!
Country [292]
0
0
Italy
Query!
State/province [292]
0
0
SS
Query!
Country [293]
0
0
Italy
Query!
State/province [293]
0
0
TV
Query!
Country [294]
0
0
Italy
Query!
State/province [294]
0
0
VA
Query!
Country [295]
0
0
Italy
Query!
State/province [295]
0
0
VE
Query!
Country [296]
0
0
Italy
Query!
State/province [296]
0
0
VR
Query!
Country [297]
0
0
Italy
Query!
State/province [297]
0
0
Massa Carrara
Query!
Country [298]
0
0
Italy
Query!
State/province [298]
0
0
Napoli
Query!
Country [299]
0
0
Italy
Query!
State/province [299]
0
0
Novara
Query!
Country [300]
0
0
Korea, Republic of
Query!
State/province [300]
0
0
Gyeonggido
Query!
Country [301]
0
0
Korea, Republic of
Query!
State/province [301]
0
0
Daegu
Query!
Country [302]
0
0
Korea, Republic of
Query!
State/province [302]
0
0
Gwangju
Query!
Country [303]
0
0
Korea, Republic of
Query!
State/province [303]
0
0
Seoul
Query!
Country [304]
0
0
Korea, Republic of
Query!
State/province [304]
0
0
Suwon
Query!
Country [305]
0
0
Korea, Republic of
Query!
State/province [305]
0
0
Wonju
Query!
Country [306]
0
0
Malaysia
Query!
State/province [306]
0
0
Sarawak
Query!
Country [307]
0
0
Malaysia
Query!
State/province [307]
0
0
Wilayah Persekutuan
Query!
Country [308]
0
0
Malaysia
Query!
State/province [308]
0
0
Penang
Query!
Country [309]
0
0
Mexico
Query!
State/province [309]
0
0
Distrito Federal
Query!
Country [310]
0
0
Mexico
Query!
State/province [310]
0
0
Jalisco
Query!
Country [311]
0
0
Mexico
Query!
State/province [311]
0
0
Nuevo Leon
Query!
Country [312]
0
0
Mexico
Query!
State/province [312]
0
0
Durango
Query!
Country [313]
0
0
Mexico
Query!
State/province [313]
0
0
Puebla
Query!
Country [314]
0
0
Netherlands
Query!
State/province [314]
0
0
Alkmaar
Query!
Country [315]
0
0
Netherlands
Query!
State/province [315]
0
0
Almelo
Query!
Country [316]
0
0
Netherlands
Query!
State/province [316]
0
0
Amersfoort
Query!
Country [317]
0
0
Netherlands
Query!
State/province [317]
0
0
Amsterdam
Query!
Country [318]
0
0
Netherlands
Query!
State/province [318]
0
0
Apeldoorn
Query!
Country [319]
0
0
Netherlands
Query!
State/province [319]
0
0
Arnhem
Query!
Country [320]
0
0
Netherlands
Query!
State/province [320]
0
0
Assen
Query!
Country [321]
0
0
Netherlands
Query!
State/province [321]
0
0
Blaricum
Query!
Country [322]
0
0
Netherlands
Query!
State/province [322]
0
0
Breda
Query!
Country [323]
0
0
Netherlands
Query!
State/province [323]
0
0
Capelle Aan Den Ijssel
Query!
Country [324]
0
0
Netherlands
Query!
State/province [324]
0
0
Delft
Query!
Country [325]
0
0
Netherlands
Query!
State/province [325]
0
0
Den Haag
Query!
Country [326]
0
0
Netherlands
Query!
State/province [326]
0
0
Deventer
Query!
Country [327]
0
0
Netherlands
Query!
State/province [327]
0
0
Dordrecht
Query!
Country [328]
0
0
Netherlands
Query!
State/province [328]
0
0
Drachten
Query!
Country [329]
0
0
Netherlands
Query!
State/province [329]
0
0
EDE
Query!
Country [330]
0
0
Netherlands
Query!
State/province [330]
0
0
Eindhoven
Query!
Country [331]
0
0
Netherlands
Query!
State/province [331]
0
0
Goes
Query!
Country [332]
0
0
Netherlands
Query!
State/province [332]
0
0
Gorinchem
Query!
Country [333]
0
0
Netherlands
Query!
State/province [333]
0
0
Gouda
Query!
Country [334]
0
0
Netherlands
Query!
State/province [334]
0
0
Haarlem
Query!
Country [335]
0
0
Netherlands
Query!
State/province [335]
0
0
Hardenberg
Query!
Country [336]
0
0
Netherlands
Query!
State/province [336]
0
0
Harderwijk
Query!
Country [337]
0
0
Netherlands
Query!
State/province [337]
0
0
Heerlen
Query!
Country [338]
0
0
Netherlands
Query!
State/province [338]
0
0
Helmond
Query!
Country [339]
0
0
Netherlands
Query!
State/province [339]
0
0
Hilversum
Query!
Country [340]
0
0
Netherlands
Query!
State/province [340]
0
0
Leeuwarden
Query!
Country [341]
0
0
Netherlands
Query!
State/province [341]
0
0
Maastricht
Query!
Country [342]
0
0
Netherlands
Query!
State/province [342]
0
0
Nieuwegein
Query!
Country [343]
0
0
Netherlands
Query!
State/province [343]
0
0
Nijmegen
Query!
Country [344]
0
0
Netherlands
Query!
State/province [344]
0
0
Rotterdam
Query!
Country [345]
0
0
Netherlands
Query!
State/province [345]
0
0
Spijkenisse
Query!
Country [346]
0
0
Netherlands
Query!
State/province [346]
0
0
Tiel
Query!
Country [347]
0
0
Netherlands
Query!
State/province [347]
0
0
Tilburg
Query!
Country [348]
0
0
Netherlands
Query!
State/province [348]
0
0
Veldhoven
Query!
Country [349]
0
0
Netherlands
Query!
State/province [349]
0
0
Vlaardingen
Query!
Country [350]
0
0
Norway
Query!
State/province [350]
0
0
Arendal
Query!
Country [351]
0
0
Norway
Query!
State/province [351]
0
0
Bergen
Query!
Country [352]
0
0
Norway
Query!
State/province [352]
0
0
Bodo
Query!
Country [353]
0
0
Norway
Query!
State/province [353]
0
0
Drammen
Query!
Country [354]
0
0
Norway
Query!
State/province [354]
0
0
Flekkefjord
Query!
Country [355]
0
0
Norway
Query!
State/province [355]
0
0
Gjovik
Query!
Country [356]
0
0
Norway
Query!
State/province [356]
0
0
Hamar
Query!
Country [357]
0
0
Norway
Query!
State/province [357]
0
0
Kongsberg
Query!
Country [358]
0
0
Norway
Query!
State/province [358]
0
0
Kristiansand
Query!
Country [359]
0
0
Norway
Query!
State/province [359]
0
0
Lillehammer
Query!
Country [360]
0
0
Norway
Query!
State/province [360]
0
0
Nordbyhagen
Query!
Country [361]
0
0
Norway
Query!
State/province [361]
0
0
Notodden
Query!
Country [362]
0
0
Norway
Query!
State/province [362]
0
0
Oslo
Query!
Country [363]
0
0
Norway
Query!
State/province [363]
0
0
RUD
Query!
Country [364]
0
0
Norway
Query!
State/province [364]
0
0
Tromso
Query!
Country [365]
0
0
Norway
Query!
State/province [365]
0
0
Tynset
Query!
Country [366]
0
0
Philippines
Query!
State/province [366]
0
0
Cebu
Query!
Country [367]
0
0
Philippines
Query!
State/province [367]
0
0
Davao City
Query!
Country [368]
0
0
Philippines
Query!
State/province [368]
0
0
Manila
Query!
Country [369]
0
0
Philippines
Query!
State/province [369]
0
0
Pasig City
Query!
Country [370]
0
0
Philippines
Query!
State/province [370]
0
0
Quezon City
Query!
Country [371]
0
0
Poland
Query!
State/province [371]
0
0
Bialystok
Query!
Country [372]
0
0
Poland
Query!
State/province [372]
0
0
Bielsko-biala
Query!
Country [373]
0
0
Poland
Query!
State/province [373]
0
0
Bydgoszcz
Query!
Country [374]
0
0
Poland
Query!
State/province [374]
0
0
Bytom
Query!
Country [375]
0
0
Poland
Query!
State/province [375]
0
0
Czestochowa
Query!
Country [376]
0
0
Poland
Query!
State/province [376]
0
0
Elblag
Query!
Country [377]
0
0
Poland
Query!
State/province [377]
0
0
Gda?sk
Query!
Country [378]
0
0
Poland
Query!
State/province [378]
0
0
Gdynia
Query!
Country [379]
0
0
Poland
Query!
State/province [379]
0
0
Grodzisk Mazowiecki
Query!
Country [380]
0
0
Poland
Query!
State/province [380]
0
0
Inowroclaw
Query!
Country [381]
0
0
Poland
Query!
State/province [381]
0
0
Katowice
Query!
Country [382]
0
0
Poland
Query!
State/province [382]
0
0
Krakow
Query!
Country [383]
0
0
Poland
Query!
State/province [383]
0
0
Lodz
Query!
Country [384]
0
0
Poland
Query!
State/province [384]
0
0
Lublin
Query!
Country [385]
0
0
Poland
Query!
State/province [385]
0
0
Olawa
Query!
Country [386]
0
0
Poland
Query!
State/province [386]
0
0
Olsztyn
Query!
Country [387]
0
0
Poland
Query!
State/province [387]
0
0
Opole
Query!
Country [388]
0
0
Poland
Query!
State/province [388]
0
0
Ostrowiec Swietokrzyski
Query!
Country [389]
0
0
Poland
Query!
State/province [389]
0
0
Plock
Query!
Country [390]
0
0
Poland
Query!
State/province [390]
0
0
Poznan
Query!
Country [391]
0
0
Poland
Query!
State/province [391]
0
0
Radom
Query!
Country [392]
0
0
Poland
Query!
State/province [392]
0
0
Szczecin
Query!
Country [393]
0
0
Poland
Query!
State/province [393]
0
0
Tarnow
Query!
Country [394]
0
0
Poland
Query!
State/province [394]
0
0
Torun
Query!
Country [395]
0
0
Poland
Query!
State/province [395]
0
0
Walbrzych
Query!
Country [396]
0
0
Poland
Query!
State/province [396]
0
0
Warszawa
Query!
Country [397]
0
0
Poland
Query!
State/province [397]
0
0
Wejherowo
Query!
Country [398]
0
0
Poland
Query!
State/province [398]
0
0
Wloclawek
Query!
Country [399]
0
0
Poland
Query!
State/province [399]
0
0
Wroclaw
Query!
Country [400]
0
0
Poland
Query!
State/province [400]
0
0
Zamosc
Query!
Country [401]
0
0
Portugal
Query!
State/province [401]
0
0
Amadora
Query!
Country [402]
0
0
Portugal
Query!
State/province [402]
0
0
Aveiro
Query!
Country [403]
0
0
Portugal
Query!
State/province [403]
0
0
Braga
Query!
Country [404]
0
0
Portugal
Query!
State/province [404]
0
0
Coimbra
Query!
Country [405]
0
0
Portugal
Query!
State/province [405]
0
0
Leiria
Query!
Country [406]
0
0
Portugal
Query!
State/province [406]
0
0
Lisboa
Query!
Country [407]
0
0
Portugal
Query!
State/province [407]
0
0
Penafiel
Query!
Country [408]
0
0
Portugal
Query!
State/province [408]
0
0
Santa Maria Da Feira
Query!
Country [409]
0
0
Portugal
Query!
State/province [409]
0
0
Santarem
Query!
Country [410]
0
0
Portugal
Query!
State/province [410]
0
0
Setubal
Query!
Country [411]
0
0
Portugal
Query!
State/province [411]
0
0
Vila Nova de Gaia
Query!
Country [412]
0
0
Portugal
Query!
State/province [412]
0
0
Vila Real
Query!
Country [413]
0
0
Puerto Rico
Query!
State/province [413]
0
0
San Juan
Query!
Country [414]
0
0
Romania
Query!
State/province [414]
0
0
Arges
Query!
Country [415]
0
0
Romania
Query!
State/province [415]
0
0
Cluj
Query!
Country [416]
0
0
Romania
Query!
State/province [416]
0
0
Braila
Query!
Country [417]
0
0
Romania
Query!
State/province [417]
0
0
Brasov
Query!
Country [418]
0
0
Romania
Query!
State/province [418]
0
0
Bucharest
Query!
Country [419]
0
0
Romania
Query!
State/province [419]
0
0
Buzau
Query!
Country [420]
0
0
Romania
Query!
State/province [420]
0
0
Craiova
Query!
Country [421]
0
0
Romania
Query!
State/province [421]
0
0
Iasi
Query!
Country [422]
0
0
Romania
Query!
State/province [422]
0
0
Suceava
Query!
Country [423]
0
0
Russian Federation
Query!
State/province [423]
0
0
Khanty-mansiysk Autonomous Dis
Query!
Country [424]
0
0
Russian Federation
Query!
State/province [424]
0
0
Barnaul
Query!
Country [425]
0
0
Russian Federation
Query!
State/province [425]
0
0
Ekaterinburg
Query!
Country [426]
0
0
Russian Federation
Query!
State/province [426]
0
0
Irkutsk
Query!
Country [427]
0
0
Russian Federation
Query!
State/province [427]
0
0
Kaliningrad
Query!
Country [428]
0
0
Russian Federation
Query!
State/province [428]
0
0
Kazan
Query!
Country [429]
0
0
Russian Federation
Query!
State/province [429]
0
0
Kemerovo
Query!
Country [430]
0
0
Russian Federation
Query!
State/province [430]
0
0
Krasnodar
Query!
Country [431]
0
0
Russian Federation
Query!
State/province [431]
0
0
Krasnoyarsk
Query!
Country [432]
0
0
Russian Federation
Query!
State/province [432]
0
0
Moscow
Query!
Country [433]
0
0
Russian Federation
Query!
State/province [433]
0
0
Murmansk
Query!
Country [434]
0
0
Russian Federation
Query!
State/province [434]
0
0
Nizhniy Novgorod
Query!
Country [435]
0
0
Russian Federation
Query!
State/province [435]
0
0
Novosibirsk
Query!
Country [436]
0
0
Russian Federation
Query!
State/province [436]
0
0
Rostov-na-donu
Query!
Country [437]
0
0
Russian Federation
Query!
State/province [437]
0
0
Samara
Query!
Country [438]
0
0
Russian Federation
Query!
State/province [438]
0
0
St. Petersburg
Query!
Country [439]
0
0
Russian Federation
Query!
State/province [439]
0
0
Tomsk
Query!
Country [440]
0
0
Russian Federation
Query!
State/province [440]
0
0
Tyumen
Query!
Country [441]
0
0
Russian Federation
Query!
State/province [441]
0
0
Vladivostok
Query!
Country [442]
0
0
Singapore
Query!
State/province [442]
0
0
Singapore
Query!
Country [443]
0
0
Slovakia
Query!
State/province [443]
0
0
Bratislava
Query!
Country [444]
0
0
Slovakia
Query!
State/province [444]
0
0
Kosice
Query!
Country [445]
0
0
Slovakia
Query!
State/province [445]
0
0
Liptovsky Mikulas
Query!
Country [446]
0
0
Slovakia
Query!
State/province [446]
0
0
Martin
Query!
Country [447]
0
0
Slovakia
Query!
State/province [447]
0
0
Nitra
Query!
Country [448]
0
0
Slovakia
Query!
State/province [448]
0
0
Nove Zamky
Query!
Country [449]
0
0
Slovakia
Query!
State/province [449]
0
0
Piestany
Query!
Country [450]
0
0
Slovakia
Query!
State/province [450]
0
0
Ruzomberok
Query!
Country [451]
0
0
Slovakia
Query!
State/province [451]
0
0
Trnava
Query!
Country [452]
0
0
Slovakia
Query!
State/province [452]
0
0
Zilina
Query!
Country [453]
0
0
South Africa
Query!
State/province [453]
0
0
Cape Town
Query!
Country [454]
0
0
South Africa
Query!
State/province [454]
0
0
Free State
Query!
Country [455]
0
0
South Africa
Query!
State/province [455]
0
0
Pretoria
Query!
Country [456]
0
0
Spain
Query!
State/province [456]
0
0
Andalucia
Query!
Country [457]
0
0
Spain
Query!
State/province [457]
0
0
Asturias
Query!
Country [458]
0
0
Spain
Query!
State/province [458]
0
0
Cataluna
Query!
Country [459]
0
0
Spain
Query!
State/province [459]
0
0
Comunidad de Madrid
Query!
Country [460]
0
0
Spain
Query!
State/province [460]
0
0
Comunidad Valenciana
Query!
Country [461]
0
0
Spain
Query!
State/province [461]
0
0
Extremadura
Query!
Country [462]
0
0
Spain
Query!
State/province [462]
0
0
Galicia
Query!
Country [463]
0
0
Spain
Query!
State/province [463]
0
0
Islas Baleares
Query!
Country [464]
0
0
Sweden
Query!
State/province [464]
0
0
Boras
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Funding & Sponsors
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Commercial sector/industry
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Name
AstraZeneca
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Summary
Brief summary
Ticagrelor is a new, reversible binding, anti-platelet medication. Anti-platelet medications work to prevent the formation of blood clots. Ticagrelor is being developed as a treatment for patients with acute coronary syndrome (ACS). ACS is a term that is used to describe both heart attacks in progress or the imminent threat of a heart attack. ACS is usually caused by the formation of a blood clot in an artery that partially or totally blocks the blood supply to a portion of the heart muscle. Ticagrelor will be compared with clopidogrel to determine which drug, when either is used in conjunction with aspirin, is better at reducing deaths from vascular causes, future heart attacks and/or strokes in patients with ACS.
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Trial website
https://clinicaltrials.gov/study/NCT00391872
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Trial related presentations / publications
Natale P, Palmer SC, Saglimbene VM, Ruospo M, Razavian M, Craig JC, Jardine MJ, Webster AC, Strippoli GF. Antiplatelet agents for chronic kidney disease. Cochrane Database Syst Rev. 2022 Feb 28;2(2):CD008834. doi: 10.1002/14651858.CD008834.pub4. Samman KN, Mehanna P, Takla E, Grenier JC, Chan MY, Lopes RD, Neely ML, Wang TY, Newby LK, Becker RC, Lordkipanidze M, Ruiz M, Hussin JG, Jolicoeur EM. Differential modulation of polyunsaturated fatty acids in patients with myocardial infarction treated with ticagrelor or clopidogrel. Cell Rep Med. 2021 Jun 4;2(6):100299. doi: 10.1016/j.xcrm.2021.100299. eCollection 2021 Jun 15. Thi Thu Nguyen T, Van Do D, Mellstrom C, Quang Nguyen T, Manh Pham H, Van Hoang S, Cong Luu T, Le Phuong T. Cost-Effectiveness of Ticagrelor Compared with Clopidogrel in Patients with Acute Coronary Syndrome from Vietnamese Healthcare Payers' Perspective. Adv Ther. 2021 Jul;38(7):4026-4039. doi: 10.1007/s12325-021-01743-5. Epub 2021 Jun 11. Mahmoodi BK, Eriksson N, Vos GJA, Meijer K, Siegbahn A, James S, Wallentin L, Ten Berg JM. Factor V Leiden Does Not Modify the Phenotype of Acute Coronary Syndrome or the Extent of Myocardial Necrosis. J Am Heart Assoc. 2021 Jun;10(11):e020025. doi: 10.1161/JAHA.120.020025. Epub 2021 May 17. Gregersen I, Michelsen AE, Lunde NN, Akerblom A, Lakic TG, Skjelland M, Ryeng Skagen K, Becker RC, Lindback J, Himmelmann A, Solberg R, Johansen HT, James SK, Siegbahn A, Storey RF, Kontny F, Aukrust P, Ueland T, Wallentin L, Halvorsen B. Legumain in Acute Coronary Syndromes: A Substudy of the PLATO (Platelet Inhibition and Patient Outcomes) Trial. J Am Heart Assoc. 2020 Sep;9(17):e016360. doi: 10.1161/JAHA.120.016360. Epub 2020 Aug 15. Sumaya W, Wallentin L, James SK, Siegbahn A, Gabrysch K, Himmelmann A, Ajjan RA, Storey RF. Impaired Fibrinolysis Predicts Adverse Outcome in Acute Coronary Syndrome Patients with Diabetes: A PLATO Sub-Study. Thromb Haemost. 2020 Mar;120(3):412-422. doi: 10.1055/s-0039-1701011. Epub 2020 Jan 23. Ueland T, Akerblom A, Ghukasyan T, Michelsen AE, Becker RC, Bertilsson M, Budaj A, Cornel JH, Himmelmann A, James SK, Siegbahn A, Storey RF, Kontny F, Aukrust P, Wallentin L; PLATO Investigators. ALCAM predicts future cardiovascular death in acute coronary syndromes: Insights from the PLATO trial. Atherosclerosis. 2020 Jan;293:35-41. doi: 10.1016/j.atherosclerosis.2019.11.031. Epub 2019 Nov 29. Andersen T, Ueland T, Ghukasyan Lakic T, Akerblom A, Bertilsson M, Aukrust P, Michelsen AE, James SK, Becker RC, Storey RF, Wallentin L, Siegbahn A, Kontny F. C-X-C Ligand 16 Is an Independent Predictor of Cardiovascular Death and Morbidity in Acute Coronary Syndromes. Arterioscler Thromb Vasc Biol. 2019 Nov;39(11):2402-2410. doi: 10.1161/ATVBAHA.119.312633. Epub 2019 Sep 26. Akerblom A, Wojdyla DM, Wallentin L, James SK, de Souza Brito F, Steg PG, Cannon CP, Katus HA, Himmelmann A, Storey RF, Becker RC, Lopes RD; PLATO Investigators. Ticagrelor in patients with heart failure after acute coronary syndromes-Insights from the PLATelet inhibition and patient Outcomes (PLATO) trial. Am Heart J. 2019 Jul;213:57-65. doi: 10.1016/j.ahj.2019.04.006. Epub 2019 Apr 18. Franchi F, James SK, Ghukasyan Lakic T, Budaj AJ, Cornel JH, Katus HA, Keltai M, Kontny F, Lewis BS, Storey RF, Himmelmann A, Wallentin L, Angiolillo DJ; PLATO Investigators. Impact of Diabetes Mellitus and Chronic Kidney Disease on Cardiovascular Outcomes and Platelet P2Y12 Receptor Antagonist Effects in Patients With Acute Coronary Syndromes: Insights From the PLATO Trial. J Am Heart Assoc. 2019 Mar 19;8(6):e011139. doi: 10.1161/JAHA.118.011139. Lindholm D, James SK, Gabrysch K, Storey RF, Himmelmann A, Cannon CP, Mahaffey KW, Steg PG, Held C, Siegbahn A, Wallentin L. Association of Multiple Biomarkers With Risk of All-Cause and Cause-Specific Mortality After Acute Coronary Syndromes: A Secondary Analysis of the PLATO Biomarker Study. JAMA Cardiol. 2018 Dec 1;3(12):1160-1166. doi: 10.1001/jamacardio.2018.3811. Inohara T, Pieper K, Wojdyla DM, Patel MR, Jones WS, Tricoci P, Mahaffey KW, James SK, Alexander JH, Lopes RD, Wallentin L, Ohman EM, Roe MT, Vemulapalli S. Incidence, timing, and type of first and recurrent ischemic events in patients with and without peripheral artery disease after an acute coronary syndrome. Am Heart J. 2018 Jul;201:25-32. doi: 10.1016/j.ahj.2018.03.013. Epub 2018 Mar 28. Ueland T, Akerblom A, Ghukasyan T, Michelsen AE, Aukrust P, Becker RC, Bertilsson M, Himmelmann A, James SK, Siegbahn A, Storey RF, Kontny F, Wallentin L; PLATO (Platelet Inhibition and Patient Outcomes) Trial Investigators. Osteoprotegerin Is Associated With Major Bleeding But Not With Cardiovascular Outcomes in Patients With Acute Coronary Syndromes: Insights From the PLATO (Platelet Inhibition and Patient Outcomes) Trial. J Am Heart Assoc. 2018 Jan 12;7(2):e007009. doi: 10.1161/JAHA.117.007009. Bellavia A, Wallentin L, Orsini N, James SK, Cannon CP, Himmelmann A, Sundstrom J, Renlund H, Lytsy P. Time-based measures of treatment effect: reassessment of ticagrelor and clopidogrel from the PLATO trial. Open Heart. 2017 Jun 1;4(2):e000557. doi: 10.1136/openhrt-2016-000557. eCollection 2017. Lindholm D, Hagstrom E, James SK, Becker RC, Cannon CP, Himmelmann A, Katus HA, Maurer G, Lopez-Sendon JL, Steg PG, Storey RF, Siegbahn A, Wallentin L. Growth Differentiation Factor 15 at 1 Month After an Acute Coronary Syndrome Is Associated With Increased Risk of Major Bleeding. J Am Heart Assoc. 2017 Apr 14;6(4):e005580. doi: 10.1161/JAHA.117.005580. Lindholm D, James SK, Bertilsson M, Becker RC, Cannon CP, Giannitsis E, Harrington RA, Himmelmann A, Kontny F, Siegbahn A, Steg PG, Storey RF, Velders MA, Weaver WD, Wallentin L; PLATO Investigators. Biomarkers and Coronary Lesions Predict Outcomes after Revascularization in Non-ST-Elevation Acute Coronary Syndrome. Clin Chem. 2017 Feb;63(2):573-584. doi: 10.1373/clinchem.2016.261271. Epub 2016 Dec 8. Held P, Himmelmann A, Ditmarsch M. Ticagrelor for the treatment of atherosclerotic disease: insights from the PARTHENON clinical development program. Future Cardiol. 2016 Jul;12(4):405-18. doi: 10.2217/fca-2016-0028. Epub 2016 May 10. Johansson A, Eriksson N, Lindholm D, Varenhorst C, James S, Syvanen AC, Axelsson T, Siegbahn A, Barratt BJ, Becker RC, Himmelmann A, Katus HA, Steg PG, Storey RF, Wallentin L; PLATO Investigators. Genome-wide association and Mendelian randomization study of NT-proBNP in patients with acute coronary syndrome. Hum Mol Genet. 2016 Apr 1;25(7):1447-56. doi: 10.1093/hmg/ddw012. Epub 2016 Jan 21. Velders MA, Abtan J, Angiolillo DJ, Ardissino D, Harrington RA, Hellkamp A, Himmelmann A, Husted S, Katus HA, Meier B, Schulte PJ, Storey RF, Wallentin L, Gabriel Steg P, James SK; PLATO Investigators. Safety and efficacy of ticagrelor and clopidogrel in primary percutaneous coronary intervention. Heart. 2016 Apr;102(8):617-25. doi: 10.1136/heartjnl-2015-308963. Epub 2016 Feb 4. Bui AH, Cannon CP, Steg PG, Storey RF, Husted S, Guo J, Im K, James SK, Michelson EL, Himmelmann A, Held C, Varenhorst C, Wallentin L, Scirica BM. Relationship Between Early and Late Nonsustained Ventricular Tachycardia and Cardiovascular Death in Patients With Acute Coronary Syndrome in the Platelet Inhibition and Patient Outcomes (PLATO) Trial. Circ Arrhythm Electrophysiol. 2016 Feb;9(2):e002951. doi: 10.1161/CIRCEP.115.002951. Andell P, James SK, Cannon CP, Cyr DD, Himmelmann A, Husted S, Keltai M, Koul S, Santoso A, Steg PG, Storey RF, Wallentin L, Erlinge D; PLATO Investigators. Ticagrelor Versus Clopidogrel in Patients With Acute Coronary Syndromes and Chronic Obstructive Pulmonary Disease: An Analysis From the Platelet Inhibition and Patient Outcomes (PLATO) Trial. J Am Heart Assoc. 2015 Oct 9;4(10):e002490. doi: 10.1161/JAHA.115.002490. Hagstrom E, James SK, Bertilsson M, Becker RC, Himmelmann A, Husted S, Katus HA, Steg PG, Storey RF, Siegbahn A, Wallentin L; PLATO Investigators. Growth differentiation factor-15 level predicts major bleeding and cardiovascular events in patients with acute coronary syndromes: results from the PLATO study. Eur Heart J. 2016 Apr 21;37(16):1325-33. doi: 10.1093/eurheartj/ehv491. Epub 2015 Sep 28. Mahaffey KW, Hager R, Wojdyla D, White HD, Armstrong PW, Alexander JH, Tricoci P, Lopes RD, Ohman EM, Roe MT, Harrington RA, Wallentin L. Meta-analysis of intracranial hemorrhage in acute coronary syndromes: incidence, predictors, and clinical outcomes. J Am Heart Assoc. 2015 Jun 18;4(6):e001512. doi: 10.1161/JAHA.114.001512. Kang HJ, Clare RM, Gao R, Held C, Himmelmann A, James SK, Lim ST, Santoso A, Yu CM, Wallentin L, Becker RC; PLATO Investigators. Ticagrelor versus clopidogrel in Asian patients with acute coronary syndrome: A retrospective analysis from the Platelet Inhibition and Patient Outcomes (PLATO) Trial. Am Heart J. 2015 Jun;169(6):899-905.e1. doi: 10.1016/j.ahj.2015.03.015. Epub 2015 Mar 31. Velders MA, Wallentin L, Becker RC, van Boven AJ, Himmelmann A, Husted S, Katus HA, Lindholm D, Morais J, Siegbahn A, Storey RF, Wernroth L, James SK; PLATO Investigators. Biomarkers for risk stratification of patients with ST-elevation myocardial infarction treated with primary percutaneous coronary intervention: Insights from the Platelet Inhibition and Patient Outcomes trial. Am Heart J. 2015 Jun;169(6):879-889.e7. doi: 10.1016/j.ahj.2015.02.019. Epub 2015 Mar 5. Varenhorst C, Eriksson N, Johansson A, Barratt BJ, Hagstrom E, Akerblom A, Syvanen AC, Becker RC, James SK, Katus HA, Husted S, Steg PG, Siegbahn A, Voora D, Teng R, Storey RF, Wallentin L; PLATO Investigators. Effect of genetic variations on ticagrelor plasma levels and clinical outcomes. Eur Heart J. 2015 Aug 1;36(29):1901-12. doi: 10.1093/eurheartj/ehv116. Epub 2015 May 2. Kholaif N, Zheng Y, Jagasia P, Himmelmann A, James SK, Steg PG, Storey RF, Westerhout CM, Armstrong PW. Baseline Q waves and time from symptom onset to ST-segment elevation myocardial infarction: insights from PLATO on the influence of sex. Am J Med. 2015 Aug;128(8):914.e11-9. doi: 10.1016/j.amjmed.2015.03.005. Epub 2015 Mar 26. Cowper PA, Pan W, Anstrom KJ, Kaul P, Wallentin L, Davidson-Ray L, Nikolic E, Janzon M, Levin LA, Cannon CP, Harrington RA, Mark DB. Economic analysis of ticagrelor therapy from a U.S. perspective: results from the PLATO study. J Am Coll Cardiol. 2015 Feb 10;65(5):465-76. doi: 10.1016/j.jacc.2014.11.034. Janzon M, James S, Cannon CP, Storey RF, Mellstrom C, Nicolau JC, Wallentin L, Henriksson M. Health economic analysis of ticagrelor in patients with acute coronary syndromes intended for non-invasive therapy. Heart. 2015 Jan;101(2):119-25. doi: 10.1136/heartjnl-2014-305864. Epub 2014 Sep 16. Varenhorst C, Alstrom U, Braun OO, Storey RF, Mahaffey KW, Bertilsson M, Cannon CP, Scirica BM, Himmelmann A, James SK, Wallentin L, Held C. Causes of mortality with ticagrelor compared with clopidogrel in acute coronary syndromes. Heart. 2014 Nov;100(22):1762-9. doi: 10.1136/heartjnl-2014-305619. Epub 2014 Jun 23. Kotsia A, Brilakis ES, Held C, Cannon C, Steg GP, Meier B, Cools F, Claeys MJ, Cornel JH, Aylward P, Lewis BS, Weaver D, Brandrup-Wognsen G, Stevens SR, Himmelmann A, Wallentin L, James SK. Extent of coronary artery disease and outcomes after ticagrelor administration in patients with an acute coronary syndrome: Insights from the PLATelet inhibition and patient Outcomes (PLATO) trial. Am Heart J. 2014 Jul;168(1):68-75.e2. doi: 10.1016/j.ahj.2014.04.001. Epub 2014 Apr 13. Patel MR, Becker RC, Wojdyla DM, Emanuelsson H, Hiatt WR, Horrow J, Husted S, Mahaffey KW, Steg PG, Storey RF, Wallentin L, James SK. Cardiovascular events in acute coronary syndrome patients with peripheral arterial disease treated with ticagrelor compared with clopidogrel: Data from the PLATO Trial. Eur J Prev Cardiol. 2015 Jun;22(6):734-42. doi: 10.1177/2047487314533215. Epub 2014 May 15. Husted S, James SK, Bach RG, Becker RC, Budaj A, Heras M, Himmelmann A, Horrow J, Katus HA, Lassila R, Morais J, Nicolau JC, Steg PG, Storey RF, Wojdyla D, Wallentin L; PLATO study group. The efficacy of ticagrelor is maintained in women with acute coronary syndromes participating in the prospective, randomized, PLATelet inhibition and patient Outcomes (PLATO) trial. Eur Heart J. 2014 Jun 14;35(23):1541-50. doi: 10.1093/eurheartj/ehu075. Epub 2014 Mar 28. Mahaffey KW, Held C, Wojdyla DM, James SK, Katus HA, Husted S, Steg PG, Cannon CP, Becker RC, Storey RF, Khurmi NS, Nicolau JC, Yu CM, Ardissino D, Budaj A, Morais J, Montgomery D, Himmelmann A, Harrington RA, Wallentin L; PLATO Investigators. Ticagrelor effects on myocardial infarction and the impact of event adjudication in the PLATO (Platelet Inhibition and Patient Outcomes) trial. J Am Coll Cardiol. 2014 Apr 22;63(15):1493-9. doi: 10.1016/j.jacc.2014.01.038. Epub 2014 Feb 19. Wallentin L, Lindholm D, Siegbahn A, Wernroth L, Becker RC, Cannon CP, Cornel JH, Himmelmann A, Giannitsis E, Harrington RA, Held C, Husted S, Katus HA, Mahaffey KW, Steg PG, Storey RF, James SK; PLATO study group. Biomarkers in relation to the effects of ticagrelor in comparison with clopidogrel in non-ST-elevation acute coronary syndrome patients managed with or without in-hospital revascularization: a substudy from the Prospective Randomized Platelet Inhibition and Patient Outcomes (PLATO) trial. Circulation. 2014 Jan 21;129(3):293-303. doi: 10.1161/CIRCULATIONAHA.113.004420. Epub 2013 Oct 29. Brilakis ES, Held C, Meier B, Cools F, Claeys MJ, Cornel JH, Aylward P, Lewis BS, Weaver D, Brandrup-Wognsen G, Stevens SR, Himmelmann A, Wallentin L, James SK. Effect of ticagrelor on the outcomes of patients with prior coronary artery bypass graft surgery: insights from the PLATelet inhibition and patient outcomes (PLATO) trial. Am Heart J. 2013 Sep;166(3):474-80. doi: 10.1016/j.ahj.2013.06.019. Epub 2013 Jul 26. Steg PG, Harrington RA, Emanuelsson H, Katus HA, Mahaffey KW, Meier B, Storey RF, Wojdyla DM, Lewis BS, Maurer G, Wallentin L, James SK; PLATO Study Group. Stent thrombosis with ticagrelor versus clopidogrel in patients with acute coronary syndromes: an analysis from the prospective, randomized PLATO trial. Circulation. 2013 Sep 3;128(10):1055-65. doi: 10.1161/CIRCULATIONAHA.113.002589. Epub 2013 Jul 30. Kunadian V, James SK, Wojdyla DM, Zorkun C, Wu J, Storey RF, Steg PG, Katus H, Emanuelsson H, Horrow J, Maya J, Wallentin L, Harrington RA, Gibson CM. Angiographic outcomes in the PLATO Trial (Platelet Inhibition and Patient Outcomes). JACC Cardiovasc Interv. 2013 Jul;6(7):671-83. doi: 10.1016/j.jcin.2013.03.014. James SK, Storey RF, Pieper KS, Cannon CP, Becker RC, Steg PG, Wallentin L, Harrington RA; PLATO Study Group. Response to letter regarding article, "Ticagrelor in patients with acute coronary syndromes and stroke: interpretation of subgroups in clinical trials". Stroke. 2013 Aug;44(8):e95-6. doi: 10.1161/STROKEAHA.113.002069. Epub 2013 Jun 25. No abstract available. James SK, Pieper KS, Cannon CP, Storey RF, Becker RC, Steg PG, Wallentin L, Harrington RA; PLATO study group. Ticagrelor in patients with acute coronary syndromes and stroke: interpretation of subgroups in clinical trials. Stroke. 2013 May;44(5):1477-9. doi: 10.1161/STROKEAHA.111.000514. Epub 2013 Apr 9. No abstract available. Kohli P, Wallentin L, Reyes E, Horrow J, Husted S, Angiolillo DJ, Ardissino D, Maurer G, Morais J, Nicolau JC, Oto A, Storey RF, James SK, Cannon CP. Reduction in first and recurrent cardiovascular events with ticagrelor compared with clopidogrel in the PLATO Study. Circulation. 2013 Feb 12;127(6):673-80. doi: 10.1161/CIRCULATIONAHA.112.124248. Epub 2012 Dec 31. Akerblom A, Wallentin L, Siegbahn A, Becker RC, Budaj A, Horrow J, Husted S, Katus H, Claeys MJ, Storey RF, Asenblad N, James SK. Outcome and causes of renal deterioration evaluated by serial cystatin C measurements in acute coronary syndrome patients -- results from the PLATelet inhibition and patient Outcomes (PLATO) study. Am Heart J. 2012 Nov;164(5):728-34. doi: 10.1016/j.ahj.2012.08.017. Epub 2012 Oct 17. Varenhorst C, Alstrom U, Scirica BM, Hogue CW, Asenblad N, Storey RF, Steg PG, Horrow J, Mahaffey KW, Becker RC, James S, Cannon CP, Brandrup-Wognsen G, Wallentin L, Held C. Factors contributing to the lower mortality with ticagrelor compared with clopidogrel in patients undergoing coronary artery bypass surgery. J Am Coll Cardiol. 2012 Oct 23;60(17):1623-30. doi: 10.1016/j.jacc.2012.07.021. Epub 2012 Sep 26. Husted S, James S, Becker RC, Horrow J, Katus H, Storey RF, Cannon CP, Heras M, Lopes RD, Morais J, Mahaffey KW, Bach RG, Wojdyla D, Wallentin L; PLATO study group. Ticagrelor versus clopidogrel in elderly patients with acute coronary syndromes: a substudy from the prospective randomized PLATelet inhibition and patient Outcomes (PLATO) trial. Circ Cardiovasc Qual Outcomes. 2012 Sep 1;5(5):680-8. doi: 10.1161/CIRCOUTCOMES.111.964395. Cornel JH, Becker RC, Goodman SG, Husted S, Katus H, Santoso A, Steg G, Storey RF, Vintila M, Sun JL, Horrow J, Wallentin L, Harrington R, James S. Prior smoking status, clinical outcomes, and the comparison of ticagrelor with clopidogrel in acute coronary syndromes-insights from the PLATelet inhibition and patient Outcomes (PLATO) trial. Am Heart J. 2012 Sep;164(3):334-342.e1. doi: 10.1016/j.ahj.2012.06.005. Epub 2012 Jul 26. Nikolic E, Janzon M, Hauch O, Wallentin L, Henriksson M; PLATO Health Economic Substudy Group. Cost-effectiveness of treating acute coronary syndrome patients with ticagrelor for 12 months: results from the PLATO study. Eur Heart J. 2013 Jan;34(3):220-8. doi: 10.1093/eurheartj/ehs149. Epub 2012 Jun 19. James SK, Storey RF, Khurmi NS, Husted S, Keltai M, Mahaffey KW, Maya J, Morais J, Lopes RD, Nicolau JC, Pais P, Raev D, Lopez-Sendon JL, Stevens SR, Becker RC; PLATO Study Group. Ticagrelor versus clopidogrel in patients with acute coronary syndromes and a history of stroke or transient ischemic attack. Circulation. 2012 Jun 12;125(23):2914-21. doi: 10.1161/CIRCULATIONAHA.111.082727. Epub 2012 May 9. Siha H, Das D, Fu Y, Zheng Y, Westerhout CM, Storey RF, James S, Wallentin L, Armstrong PW. Baseline Q waves as a prognostic modulator in patients with ST-segment elevation: insights from the PLATO trial. CMAJ. 2012 Jul 10;184(10):1135-42. doi: 10.1503/cmaj.111683. Epub 2012 Apr 30. Goodman SG, Clare R, Pieper KS, Nicolau JC, Storey RF, Cantor WJ, Mahaffey KW, Angiolillo DJ, Husted S, Cannon CP, James SK, Kilhamn J, Steg PG, Harrington RA, Wallentin L; Platelet Inhibition and Patient Outcomes Trial Investigators. Association of proton pump inhibitor use on cardiovascular outcomes with clopidogrel and ticagrelor: insights from the platelet inhibition and patient outcomes trial. Circulation. 2012 Feb 28;125(8):978-86. doi: 10.1161/CIRCULATIONAHA.111.032912. Epub 2012 Jan 18. Armstrong PW, Siha H, Fu Y, Westerhout CM, Steg PG, James SK, Storey RF, Horrow J, Katus H, Clemmensen P, Harrington RA, Wallentin L. ST-elevation acute coronary syndromes in the Platelet Inhibition and Patient Outcomes (PLATO) trial: insights from the ECG substudy. Circulation. 2012 Jan 24;125(3):514-21. doi: 10.1161/CIRCULATIONAHA.111.047530. Epub 2011 Dec 16. Becker RC, Bassand JP, Budaj A, Wojdyla DM, James SK, Cornel JH, French J, Held C, Horrow J, Husted S, Lopez-Sendon J, Lassila R, Mahaffey KW, Storey RF, Harrington RA, Wallentin L. Bleeding complications with the P2Y12 receptor antagonists clopidogrel and ticagrelor in the PLATelet inhibition and patient Outcomes (PLATO) trial. Eur Heart J. 2011 Dec;32(23):2933-44. doi: 10.1093/eurheartj/ehr422. Epub 2011 Nov 16. Erratum In: Eur Heart J. 2012 Nov;33(21):2750. Mahaffey KW, Wojdyla DM, Carroll K, Becker RC, Storey RF, Angiolillo DJ, Held C, Cannon CP, James S, Pieper KS, Horrow J, Harrington RA, Wallentin L; PLATO Investigators. Ticagrelor compared with clopidogrel by geographic region in the Platelet Inhibition and Patient Outcomes (PLATO) trial. Circulation. 2011 Aug 2;124(5):544-54. doi: 10.1161/CIRCULATIONAHA.111.047498. Epub 2011 Jun 27. James SK, Roe MT, Cannon CP, Cornel JH, Horrow J, Husted S, Katus H, Morais J, Steg PG, Storey RF, Stevens S, Wallentin L, Harrington RA; PLATO Study Group. Ticagrelor versus clopidogrel in patients with acute coronary syndromes intended for non-invasive management: substudy from prospective randomised PLATelet inhibition and patient Outcomes (PLATO) trial. BMJ. 2011 Jun 17;342:d3527. doi: 10.1136/bmj.d3527. Scirica BM, Cannon CP, Emanuelsson H, Michelson EL, Harrington RA, Husted S, James S, Katus H, Pais P, Raev D, Spinar J, Steg PG, Storey RF, Wallentin L; PLATO Investigators. The incidence of bradyarrhythmias and clinical bradyarrhythmic events in patients with acute coronary syndromes treated with ticagrelor or clopidogrel in the PLATO (Platelet Inhibition and Patient Outcomes) trial: results of the continuous electrocardiographic assessment substudy. J Am Coll Cardiol. 2011 May 10;57(19):1908-16. doi: 10.1016/j.jacc.2010.11.056. Steg PG, James S, Harrington RA, Ardissino D, Becker RC, Cannon CP, Emanuelsson H, Finkelstein A, Husted S, Katus H, Kilhamn J, Olofsson S, Storey RF, Weaver WD, Wallentin L; PLATO Study Group. Ticagrelor versus clopidogrel in patients with ST-elevation acute coronary syndromes intended for reperfusion with primary percutaneous coronary intervention: A Platelet Inhibition and Patient Outcomes (PLATO) trial subgroup analysis. Circulation. 2010 Nov 23;122(21):2131-41. doi: 10.1161/CIRCULATIONAHA.109.927582. Epub 2010 Nov 8. James S, Budaj A, Aylward P, Buck KK, Cannon CP, Cornel JH, Harrington RA, Horrow J, Katus H, Keltai M, Lewis BS, Parikh K, Storey RF, Szummer K, Wojdyla D, Wallentin L. Ticagrelor versus clopidogrel in acute coronary syndromes in relation to renal function: results from the Platelet Inhibition and Patient Outcomes (PLATO) trial. Circulation. 2010 Sep 14;122(11):1056-67. doi: 10.1161/CIRCULATIONAHA.109.933796. Epub 2010 Aug 30. Cannon CP, Harrington RA, James S, Ardissino D, Becker RC, Emanuelsson H, Husted S, Katus H, Keltai M, Khurmi NS, Kontny F, Lewis BS, Steg PG, Storey RF, Wojdyla D, Wallentin L; PLATelet inhibition and patient Outcomes Investigators. Comparison of ticagrelor with clopidogrel in patients with a planned invasive strategy for acute coronary syndromes (PLATO): a randomised double-blind study. Lancet. 2010 Jan 23;375(9711):283-93. doi: 10.1016/S0140-6736(09)62191-7. Epub 2010 Jan 13. Wallentin L, Becker RC, Budaj A, Cannon CP, Emanuelsson H, Held C, Horrow J, Husted S, James S, Katus H, Mahaffey KW, Scirica BM, Skene A, Steg PG, Storey RF, Harrington RA; PLATO Investigators; Freij A, Thorsen M. Ticagrelor versus clopidogrel in patients with acute coronary syndromes. N Engl J Med. 2009 Sep 10;361(11):1045-57. doi: 10.1056/NEJMoa0904327. Epub 2009 Aug 30. Molecule of the month. Ticagrelor. Drug News Perspect. 2007 May;20(4):264. No abstract available.
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