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Trial details imported from ClinicalTrials.gov
For full trial details, please see the original record at
https://clinicaltrials.gov/study/NCT00403767
Registration number
NCT00403767
Ethics application status
Date submitted
23/11/2006
Date registered
27/11/2006
Date last updated
29/04/2014
Titles & IDs
Public title
An Efficacy and Safety Study of Rivaroxaban With Warfarin for the Prevention of Stroke and Non-Central Nervous System Systemic Embolism in Patients With Non-Valvular Atrial Fibrillation
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Scientific title
A Prospective, Randomized, Double-Blind, Parallel-Group, Multicenter, Non-inferiority Study Comparing the Efficacy and Safety of Rivaroxaban (BAY 59-7939) With Warfarin for the Prevention of Stroke and Non-Central Nervous System Systemic Embolism in Subjects With Non-Valvular Atrial Fibrillation
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Secondary ID [1]
0
0
39039039AFL3001
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Secondary ID [2]
0
0
CR012157
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Universal Trial Number (UTN)
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Trial acronym
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Linked study record
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Health condition
Health condition(s) or problem(s) studied:
Atrial Fibrillation
0
0
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Stroke
0
0
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Embolism
0
0
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Condition category
Condition code
Stroke
0
0
0
0
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Haemorrhagic
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Stroke
0
0
0
0
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Ischaemic
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Cardiovascular
0
0
0
0
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Other cardiovascular diseases
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Cardiovascular
0
0
0
0
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Diseases of the vasculature and circulation including the lymphatic system
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Blood
0
0
0
0
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Clotting disorders
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Intervention/exposure
Study type
Interventional
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Description of intervention(s) / exposure
Treatment: Drugs - Rivaroxaban
Treatment: Drugs - Warfarin
Treatment: Drugs - Matching placebo for Rivaroxaban arm (Warfarin placebo)
Treatment: Drugs - Matching placebo for Warfarin arm (Rivaroxaban placebo)
Experimental: Rivaroxaban -
Active comparator: Warfarin -
Treatment: Drugs: Rivaroxaban
Type=exact number, unit=mg, number=20, form=tablet, route=oral use. One 20 mg tablet once daily for an expected maximum treatment period of up to 32 months that may extend up to 4 years (Patients with moderate renal impairment at screening willl have a dose adaptation to rivaroxaban 15 mg, orally, once daily for an expected maximum treatment period of up to 32 months that may extend up to 4 years)
Treatment: Drugs: Warfarin
Type=exact number, unit=mg, number=1, 2.5, or 5 mg, form=tablet, route=oral use. Number of warfarin tablets to be determined based on target INR values once daily for an expected maximum treatment period of up to 32 months that may extend up to 4 years
Treatment: Drugs: Matching placebo for Rivaroxaban arm (Warfarin placebo)
Form=tablet, route=oral. One warfarin placebo tablet taken orally once daily for up to an expected maximum treatment period of 32 months that may extend up to 4 years
Treatment: Drugs: Matching placebo for Warfarin arm (Rivaroxaban placebo)
Form-tablet, Route=oral administration. Number of rivaroxaban placebo determined by the number of warfarin tablets taken. Duration of treatment is up to an expected maximum treatment period of 32 months that may extend up to 4 years
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Intervention code [1]
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0
Treatment: Drugs
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Comparator / control treatment
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Control group
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Outcomes
Primary outcome [1]
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The Composite Event of Stroke/Non-CNS Systemic Embolism: Primary Efficacy (Non-Inferiority)
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Assessment method [1]
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The number of patients with the first occurrence of a stroke or non-CNS systemic embolism while on treatment (defined as the time interval from the first dose to the last dose of study drug plus 2 days). The statistical analysis is based on time from randomization to the first occurrence of the event while on treatment.
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Timepoint [1]
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Up to 4 years
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Primary outcome [2]
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The Composite of Event of Stroke/Non-CNS Systemic Embolism: Primary Efficacy (Superiority)
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Assessment method [2]
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The number of patients with the first occurrence of a stroke or non-CNS systemic embolism while on treatment (defined as the time interval from the first dose to the last dose of study drug plus 2 days). The statistical analysis is based on time from randomization to the first occurrence of the event while on treatment.
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Timepoint [2]
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Up to 4 years
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Primary outcome [3]
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The Composite Event of Major/Non-major Clinically Relevant Bleeding Events: Primary Safety
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Assessment method [3]
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The number of patients with the first occurrence of a major or non-major clinically relevant bleeding event while on treatment. The statistical analysis is based on time from the first dose of study drug to the first occurrence of the event while on treatment.
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Timepoint [3]
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Up to 4 years
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Secondary outcome [1]
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The Composite Event of Stroke/Non-CNS Systemic Embolism/Vascular Death
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Assessment method [1]
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The number of patients with the first occurrence of a stroke, non-CNS systemic embolism, or vascular death while on treatment. The statistical analysis is based on time from randomization to the first occurrence of the event while on treatment.
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Timepoint [1]
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0
Up to 4 years
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Secondary outcome [2]
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The Composite Event of Stroke/Non-CNS Systemic Embolism/Myocardial Infarction/Vascular Death
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Assessment method [2]
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The number of patients with the first occurrence of a stroke, non-CNS systemic embolism, myocardial infarction, or vascular death while on treatment. The statistical analysis is based on time from randomization to the first occurrence of the event while on treatment.
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Timepoint [2]
0
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Up to 4 years
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Secondary outcome [3]
0
0
The Individual Components of the Composite Primary and Major Secondary Efficacy Outcome Measures: Stroke
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Assessment method [3]
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0
The number of patients with the first occurrence of a stroke while on treatment. The statistical analysis is based on time from randomization to the first occurrence of the event while on treatment.
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Timepoint [3]
0
0
Up to 4 years
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Secondary outcome [4]
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0
The Individual Components of the Composite Primary and Major Secondary Efficacy Outcome Measures: Non-CNS Systemic Embolism
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Assessment method [4]
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0
The number of patients with the first occurrence of a non-CNS systemic embolism while on treatment. The statistical analysis is based on time from randomization to the first occurrence of the event while on treatment.
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Timepoint [4]
0
0
Up to 4 years
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Secondary outcome [5]
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The Individual Components of the Composite Primary and Major Secondary Efficacy Outcome Measures: Myocardial Infarction
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Assessment method [5]
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0
The number of patients with the first occurrence of a myocardial infarction while on treatment. The statistical analysis is based on time from randomization to the first occurrence of the event while on treatment.
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Timepoint [5]
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Up to 4 years
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Secondary outcome [6]
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0
The Individual Components of the Composite Primary and Major Secondary Efficacy Outcome Measures: Vascular Death
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Assessment method [6]
0
0
The number of patients with the occurrence of vascular death while on treatment. The statistical analysis is based on time from randomization to the event while on treatment.
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Timepoint [6]
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Up to 4 years
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Secondary outcome [7]
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All-cause Mortality
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Assessment method [7]
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The number of patients who died due to any cause while on treatment. The statistical analysis is based on time from randomization to the event while on treatment.
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Timepoint [7]
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Up to 4 years
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Eligibility
Key inclusion criteria
* Patients must have documented atrial fibrillation on 2 separate occasions within 6 months before screening
* History of a prior stroke, transient ischemic attack or non-neurologic systemic embolism believed to be cardiac in origin, or at least two of the following risk factors: heart failure, hypertension, age 75 years or greater, diabetes mellitus
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Minimum age
18
Years
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Maximum age
No limit
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Sex
Both males and females
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Can healthy volunteers participate?
No
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Key exclusion criteria
* Significant mitral stenosis
* Transient atrial fibrillation caused by a reversible disorder
* Active internal bleeding
* Severe disabling stroke
* History of intracranial bleeding
* Hemorrhagic disorders
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Study design
Purpose of the study
Prevention
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Allocation to intervention
Randomised controlled trial
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Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures)
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Methods used to generate the sequence in which subjects will be randomised (sequence generation)
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Masking / blinding
Blinded (masking used)
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Who is / are masked / blinded?
The people receiving the treatment/s
The people administering the treatment/s
The people assessing the outcomes
The people analysing the results/data
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Intervention assignment
Parallel
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Other design features
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Phase
Phase 3
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Type of endpoint/s
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Statistical methods / analysis
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Recruitment
Recruitment status
Completed
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Data analysis
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Reason for early stopping/withdrawal
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Other reasons
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Date of first participant enrolment
Anticipated
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Actual
1/12/2006
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Date of last participant enrolment
Anticipated
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Actual
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Date of last data collection
Anticipated
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Actual
1/09/2010
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Sample size
Target
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Accrual to date
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Final
14269
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Recruitment in Australia
Recruitment state(s)
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Recruitment hospital [1]
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- Adelaide
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- Auchenflower
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- Bedford Park
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- Box Hill
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- Caboolture
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- Cairns
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- Camperdown
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- Chermside
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- Clayton
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- Coffs Harbour
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- Footscray
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- Garran
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- Geelong
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- Gosford
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- Heidelberg Heights
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- Herston
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- Hobart
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- Joondalup
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- Lismore
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- Liverpool
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- Miranda
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- Nedlands
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- New Lambton Heights
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- Parkville
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Recruitment hospital [25]
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- Penrith
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- Prahran
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Recruitment hospital [27]
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- Reservoir
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Recruitment hospital [28]
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- Southport
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Recruitment hospital [29]
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- Windsor
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Recruitment hospital [30]
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- Wolloongabba
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Recruitment postcode(s) [1]
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- Adelaide
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Recruitment postcode(s) [2]
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- Auchenflower
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Recruitment postcode(s) [3]
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- Bedford Park
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Recruitment postcode(s) [4]
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- Box Hill
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Recruitment postcode(s) [5]
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- Caboolture
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Recruitment postcode(s) [6]
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- Cairns
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Recruitment postcode(s) [7]
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- Camperdown
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Recruitment postcode(s) [8]
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- Chermside
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Recruitment postcode(s) [9]
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- Clayton
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Recruitment postcode(s) [10]
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- Coffs Harbour
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Recruitment postcode(s) [11]
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- Footscray
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Recruitment postcode(s) [12]
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- Garran
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Recruitment postcode(s) [13]
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- Geelong
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Recruitment postcode(s) [14]
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- Gosford
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Recruitment postcode(s) [15]
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- Heidelberg Heights
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Recruitment postcode(s) [16]
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- Herston
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Recruitment postcode(s) [17]
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- Hobart
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Recruitment postcode(s) [18]
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- Joondalup
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Recruitment postcode(s) [19]
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- Lismore
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Recruitment postcode(s) [20]
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- Liverpool
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Recruitment postcode(s) [21]
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- Miranda
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Recruitment postcode(s) [22]
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- Nedlands
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Recruitment postcode(s) [23]
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- New Lambton Heights
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Recruitment postcode(s) [24]
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- Parkville
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Recruitment postcode(s) [25]
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- Penrith
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Recruitment postcode(s) [26]
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- Prahran
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Recruitment postcode(s) [27]
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- Reservoir
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Recruitment postcode(s) [28]
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- Southport
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Recruitment postcode(s) [29]
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- Windsor
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Recruitment postcode(s) [30]
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- Wolloongabba
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Recruitment outside Australia
Country [1]
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United States of America
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State/province [1]
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Alabama
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Arizona
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Colorado
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Connecticut
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Delaware
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Florida
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Georgia
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Idaho
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Illinois
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Louisiana
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Cipolletti
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Ciudad Autonoma De Buenos Aires
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Roeselare
Query!
Country [79]
0
0
Belgium
Query!
State/province [79]
0
0
Seraing
Query!
Country [80]
0
0
Belgium
Query!
State/province [80]
0
0
Tienen
Query!
Country [81]
0
0
Brazil
Query!
State/province [81]
0
0
Belo Horizonte
Query!
Country [82]
0
0
Brazil
Query!
State/province [82]
0
0
Blumenau
Query!
Country [83]
0
0
Brazil
Query!
State/province [83]
0
0
Brasilia
Query!
Country [84]
0
0
Brazil
Query!
State/province [84]
0
0
Campina Grande Do Sul
Query!
Country [85]
0
0
Brazil
Query!
State/province [85]
0
0
Campinas
Query!
Country [86]
0
0
Brazil
Query!
State/province [86]
0
0
Campo Grande
Query!
Country [87]
0
0
Brazil
Query!
State/province [87]
0
0
Curitiba
Query!
Country [88]
0
0
Brazil
Query!
State/province [88]
0
0
Fortaleza
Query!
Country [89]
0
0
Brazil
Query!
State/province [89]
0
0
Goiania
Query!
Country [90]
0
0
Brazil
Query!
State/province [90]
0
0
Goiânia
Query!
Country [91]
0
0
Brazil
Query!
State/province [91]
0
0
Maceio
Query!
Country [92]
0
0
Brazil
Query!
State/province [92]
0
0
Marilia
Query!
Country [93]
0
0
Brazil
Query!
State/province [93]
0
0
Maringa
Query!
Country [94]
0
0
Brazil
Query!
State/province [94]
0
0
Porto Alegre
Query!
Country [95]
0
0
Brazil
Query!
State/province [95]
0
0
Recife
Query!
Country [96]
0
0
Brazil
Query!
State/province [96]
0
0
Rio De Janeiro Br
Query!
Country [97]
0
0
Brazil
Query!
State/province [97]
0
0
Rio De Janeiro
Query!
Country [98]
0
0
Brazil
Query!
State/province [98]
0
0
Salvador
Query!
Country [99]
0
0
Brazil
Query!
State/province [99]
0
0
Santo Andre
Query!
Country [100]
0
0
Brazil
Query!
State/province [100]
0
0
Sao Caetano Do Sul
Query!
Country [101]
0
0
Brazil
Query!
State/province [101]
0
0
Sao Paulo
Query!
Country [102]
0
0
Brazil
Query!
State/province [102]
0
0
Sorocaba
Query!
Country [103]
0
0
Brazil
Query!
State/province [103]
0
0
São José Do Rio Preto
Query!
Country [104]
0
0
Brazil
Query!
State/province [104]
0
0
São Paulo
Query!
Country [105]
0
0
Brazil
Query!
State/province [105]
0
0
Uberlandia
Query!
Country [106]
0
0
Bulgaria
Query!
State/province [106]
0
0
Dimitrovgrad
Query!
Country [107]
0
0
Bulgaria
Query!
State/province [107]
0
0
Pleven
Query!
Country [108]
0
0
Bulgaria
Query!
State/province [108]
0
0
Plovdiv
Query!
Country [109]
0
0
Bulgaria
Query!
State/province [109]
0
0
Russel
Query!
Country [110]
0
0
Bulgaria
Query!
State/province [110]
0
0
Sofia
Query!
Country [111]
0
0
Bulgaria
Query!
State/province [111]
0
0
Veliko Turnovo
Query!
Country [112]
0
0
Canada
Query!
State/province [112]
0
0
Alberta
Query!
Country [113]
0
0
Canada
Query!
State/province [113]
0
0
British Columbia
Query!
Country [114]
0
0
Canada
Query!
State/province [114]
0
0
Manitoba
Query!
Country [115]
0
0
Canada
Query!
State/province [115]
0
0
New Brunswick
Query!
Country [116]
0
0
Canada
Query!
State/province [116]
0
0
Newfoundland and Labrador
Query!
Country [117]
0
0
Canada
Query!
State/province [117]
0
0
Nova Scotia
Query!
Country [118]
0
0
Canada
Query!
State/province [118]
0
0
Ontario
Query!
Country [119]
0
0
Canada
Query!
State/province [119]
0
0
Quebec
Query!
Country [120]
0
0
Canada
Query!
State/province [120]
0
0
Saskatchewan
Query!
Country [121]
0
0
Chile
Query!
State/province [121]
0
0
Arica I Region
Query!
Country [122]
0
0
Chile
Query!
State/province [122]
0
0
Chila
Query!
Country [123]
0
0
Chile
Query!
State/province [123]
0
0
Concepción Viii
Query!
Country [124]
0
0
Chile
Query!
State/province [124]
0
0
Osorno X Region
Query!
Country [125]
0
0
Chile
Query!
State/province [125]
0
0
Osorno X Región
Query!
Country [126]
0
0
Chile
Query!
State/province [126]
0
0
Rancagua Vi Region
Query!
Country [127]
0
0
Chile
Query!
State/province [127]
0
0
San Felipe V Region
Query!
Country [128]
0
0
Chile
Query!
State/province [128]
0
0
Santiago De Chile Rm
Query!
Country [129]
0
0
Chile
Query!
State/province [129]
0
0
Santiago Rm
Query!
Country [130]
0
0
Chile
Query!
State/province [130]
0
0
Temuco Ix
Query!
Country [131]
0
0
Chile
Query!
State/province [131]
0
0
Valdivia X Región
Query!
Country [132]
0
0
Chile
Query!
State/province [132]
0
0
Viña Del Mar V Región
Query!
Country [133]
0
0
China
Query!
State/province [133]
0
0
Bei Jing
Query!
Country [134]
0
0
China
Query!
State/province [134]
0
0
Beijing
Query!
Country [135]
0
0
China
Query!
State/province [135]
0
0
Changchun
Query!
Country [136]
0
0
China
Query!
State/province [136]
0
0
Changsha
Query!
Country [137]
0
0
China
Query!
State/province [137]
0
0
Changzhou
Query!
Country [138]
0
0
China
Query!
State/province [138]
0
0
Chengdu
Query!
Country [139]
0
0
China
Query!
State/province [139]
0
0
Chongqing
Query!
Country [140]
0
0
China
Query!
State/province [140]
0
0
Dalian
Query!
Country [141]
0
0
China
Query!
State/province [141]
0
0
Daqing
Query!
Country [142]
0
0
China
Query!
State/province [142]
0
0
Guangzhou
Query!
Country [143]
0
0
China
Query!
State/province [143]
0
0
Haikou
Query!
Country [144]
0
0
China
Query!
State/province [144]
0
0
Hangzhou
Query!
Country [145]
0
0
China
Query!
State/province [145]
0
0
Harbin
Query!
Country [146]
0
0
China
Query!
State/province [146]
0
0
Jinan
Query!
Country [147]
0
0
China
Query!
State/province [147]
0
0
Nanjing
Query!
Country [148]
0
0
China
Query!
State/province [148]
0
0
Shanghai
Query!
Country [149]
0
0
China
Query!
State/province [149]
0
0
Shenyang
Query!
Country [150]
0
0
China
Query!
State/province [150]
0
0
Su Zhou
Query!
Country [151]
0
0
China
Query!
State/province [151]
0
0
Suzhou
Query!
Country [152]
0
0
China
Query!
State/province [152]
0
0
Tianjin
Query!
Country [153]
0
0
China
Query!
State/province [153]
0
0
Wuhan
Query!
Country [154]
0
0
China
Query!
State/province [154]
0
0
Xian
Query!
Country [155]
0
0
Colombia
Query!
State/province [155]
0
0
Barranquilla Atlántico Atlanti
Query!
Country [156]
0
0
Colombia
Query!
State/province [156]
0
0
Barranquilla
Query!
Country [157]
0
0
Colombia
Query!
State/province [157]
0
0
Bogota D C
Query!
Country [158]
0
0
Colombia
Query!
State/province [158]
0
0
Bogota Dc
Query!
Country [159]
0
0
Colombia
Query!
State/province [159]
0
0
Bogotá Dc Dc
Query!
Country [160]
0
0
Colombia
Query!
State/province [160]
0
0
Bogotá Dc
Query!
Country [161]
0
0
Colombia
Query!
State/province [161]
0
0
Cali Valle Del Cauca
Query!
Country [162]
0
0
Colombia
Query!
State/province [162]
0
0
Cali Valley Del Cauca
Query!
Country [163]
0
0
Colombia
Query!
State/province [163]
0
0
Medellin Antioquia
Query!
Country [164]
0
0
Colombia
Query!
State/province [164]
0
0
Medellin
Query!
Country [165]
0
0
Colombia
Query!
State/province [165]
0
0
Santander
Query!
Country [166]
0
0
Czech Republic
Query!
State/province [166]
0
0
Brno 2
Query!
Country [167]
0
0
Czech Republic
Query!
State/province [167]
0
0
Chomutov
Query!
Country [168]
0
0
Czech Republic
Query!
State/province [168]
0
0
Hradec Kralove
Query!
Country [169]
0
0
Czech Republic
Query!
State/province [169]
0
0
Karviná 4
Query!
Country [170]
0
0
Czech Republic
Query!
State/province [170]
0
0
Kutna Hora N/A
Query!
Country [171]
0
0
Czech Republic
Query!
State/province [171]
0
0
Liberec
Query!
Country [172]
0
0
Czech Republic
Query!
State/province [172]
0
0
Litomysl
Query!
Country [173]
0
0
Czech Republic
Query!
State/province [173]
0
0
Náchod 1
Query!
Country [174]
0
0
Czech Republic
Query!
State/province [174]
0
0
Olomouc
Query!
Country [175]
0
0
Czech Republic
Query!
State/province [175]
0
0
Ostrava
Query!
Country [176]
0
0
Czech Republic
Query!
State/province [176]
0
0
Pardubice
Query!
Country [177]
0
0
Czech Republic
Query!
State/province [177]
0
0
Praha 10 N/A
Query!
Country [178]
0
0
Czech Republic
Query!
State/province [178]
0
0
Praha 1
Query!
Country [179]
0
0
Czech Republic
Query!
State/province [179]
0
0
Praha 2
Query!
Country [180]
0
0
Czech Republic
Query!
State/province [180]
0
0
Praha 4
Query!
Country [181]
0
0
Czech Republic
Query!
State/province [181]
0
0
Praha 5
Query!
Country [182]
0
0
Czech Republic
Query!
State/province [182]
0
0
Praha 8
Query!
Country [183]
0
0
Czech Republic
Query!
State/province [183]
0
0
Praha
Query!
Country [184]
0
0
Czech Republic
Query!
State/province [184]
0
0
Slany
Query!
Country [185]
0
0
Czech Republic
Query!
State/province [185]
0
0
Svitavy 2
Query!
Country [186]
0
0
Czech Republic
Query!
State/province [186]
0
0
Svitavy
Query!
Country [187]
0
0
Czech Republic
Query!
State/province [187]
0
0
Trutnov
Query!
Country [188]
0
0
Czech Republic
Query!
State/province [188]
0
0
Uherské Hradistì 6
Query!
Country [189]
0
0
Czech Republic
Query!
State/province [189]
0
0
Zlín 1
Query!
Country [190]
0
0
Denmark
Query!
State/province [190]
0
0
Esbjerg
Query!
Country [191]
0
0
Denmark
Query!
State/province [191]
0
0
Frederiksberg
Query!
Country [192]
0
0
Denmark
Query!
State/province [192]
0
0
Gentofte
Query!
Country [193]
0
0
Denmark
Query!
State/province [193]
0
0
Hellerup
Query!
Country [194]
0
0
Denmark
Query!
State/province [194]
0
0
Helsingør
Query!
Country [195]
0
0
Denmark
Query!
State/province [195]
0
0
Hvidovre
Query!
Country [196]
0
0
Denmark
Query!
State/province [196]
0
0
Koege
Query!
Country [197]
0
0
Denmark
Query!
State/province [197]
0
0
København
Query!
Country [198]
0
0
Denmark
Query!
State/province [198]
0
0
Næstved
Query!
Country [199]
0
0
Denmark
Query!
State/province [199]
0
0
Roskilde
Query!
Country [200]
0
0
Denmark
Query!
State/province [200]
0
0
Slagelse
Query!
Country [201]
0
0
Denmark
Query!
State/province [201]
0
0
Viborg
Query!
Country [202]
0
0
Finland
Query!
State/province [202]
0
0
Helsinki
Query!
Country [203]
0
0
Finland
Query!
State/province [203]
0
0
Jyväskylä N/A
Query!
Country [204]
0
0
Finland
Query!
State/province [204]
0
0
Kuopio
Query!
Country [205]
0
0
Finland
Query!
State/province [205]
0
0
Mikkeli
Query!
Country [206]
0
0
Finland
Query!
State/province [206]
0
0
Oulu
Query!
Country [207]
0
0
Finland
Query!
State/province [207]
0
0
Turku
Query!
Country [208]
0
0
France
Query!
State/province [208]
0
0
Albi
Query!
Country [209]
0
0
France
Query!
State/province [209]
0
0
Arras
Query!
Country [210]
0
0
France
Query!
State/province [210]
0
0
Bayonne
Query!
Country [211]
0
0
France
Query!
State/province [211]
0
0
Belfort
Query!
Country [212]
0
0
France
Query!
State/province [212]
0
0
Besancon N/A
Query!
Country [213]
0
0
France
Query!
State/province [213]
0
0
Bourg En Bresse
Query!
Country [214]
0
0
France
Query!
State/province [214]
0
0
Brest
Query!
Country [215]
0
0
France
Query!
State/province [215]
0
0
Béziers Languedoc-Roussillon
Query!
Country [216]
0
0
France
Query!
State/province [216]
0
0
Carcassonne
Query!
Country [217]
0
0
France
Query!
State/province [217]
0
0
Clermont Ferrand
Query!
Country [218]
0
0
France
Query!
State/province [218]
0
0
Corbeil Essonnes
Query!
Country [219]
0
0
France
Query!
State/province [219]
0
0
Lille
Query!
Country [220]
0
0
France
Query!
State/province [220]
0
0
Marseille
Query!
Country [221]
0
0
France
Query!
State/province [221]
0
0
Montbeliard
Query!
Country [222]
0
0
France
Query!
State/province [222]
0
0
Montpellier
Query!
Country [223]
0
0
France
Query!
State/province [223]
0
0
Paris Cedex 14
Query!
Country [224]
0
0
France
Query!
State/province [224]
0
0
Paris
Query!
Country [225]
0
0
France
Query!
State/province [225]
0
0
Perpignan
Query!
Country [226]
0
0
France
Query!
State/province [226]
0
0
Poitiers
Query!
Country [227]
0
0
France
Query!
State/province [227]
0
0
Saint-Brieuc
Query!
Country [228]
0
0
France
Query!
State/province [228]
0
0
St Jean De Verges
Query!
Country [229]
0
0
France
Query!
State/province [229]
0
0
Strasbourg
Query!
Country [230]
0
0
France
Query!
State/province [230]
0
0
Thionville
Query!
Country [231]
0
0
France
Query!
State/province [231]
0
0
Toulouse
Query!
Country [232]
0
0
France
Query!
State/province [232]
0
0
Trelivan
Query!
Country [233]
0
0
Germany
Query!
State/province [233]
0
0
Aalen
Query!
Country [234]
0
0
Germany
Query!
State/province [234]
0
0
Berlin/Spandau
Query!
Country [235]
0
0
Germany
Query!
State/province [235]
0
0
Berlin
Query!
Country [236]
0
0
Germany
Query!
State/province [236]
0
0
Biberach
Query!
Country [237]
0
0
Germany
Query!
State/province [237]
0
0
Bochum
Query!
Country [238]
0
0
Germany
Query!
State/province [238]
0
0
Bonn
Query!
Country [239]
0
0
Germany
Query!
State/province [239]
0
0
Chemnitz
Query!
Country [240]
0
0
Germany
Query!
State/province [240]
0
0
Coburg
Query!
Country [241]
0
0
Germany
Query!
State/province [241]
0
0
Dachau
Query!
Country [242]
0
0
Germany
Query!
State/province [242]
0
0
Dortmund
Query!
Country [243]
0
0
Germany
Query!
State/province [243]
0
0
Dresden
Query!
Country [244]
0
0
Germany
Query!
State/province [244]
0
0
Duisburg
Query!
Country [245]
0
0
Germany
Query!
State/province [245]
0
0
Ebersbach
Query!
Country [246]
0
0
Germany
Query!
State/province [246]
0
0
Eilenburg
Query!
Country [247]
0
0
Germany
Query!
State/province [247]
0
0
Erfurt
Query!
Country [248]
0
0
Germany
Query!
State/province [248]
0
0
Essen
Query!
Country [249]
0
0
Germany
Query!
State/province [249]
0
0
Frankfurt
Query!
Country [250]
0
0
Germany
Query!
State/province [250]
0
0
Freiburg
Query!
Country [251]
0
0
Germany
Query!
State/province [251]
0
0
Greifswald
Query!
Country [252]
0
0
Germany
Query!
State/province [252]
0
0
Halle
Query!
Country [253]
0
0
Germany
Query!
State/province [253]
0
0
Hamburg
Query!
Country [254]
0
0
Germany
Query!
State/province [254]
0
0
Hartmannsdorf
Query!
Country [255]
0
0
Germany
Query!
State/province [255]
0
0
Heidelberg
Query!
Country [256]
0
0
Germany
Query!
State/province [256]
0
0
Henstedt-Rhen
Query!
Country [257]
0
0
Germany
Query!
State/province [257]
0
0
Herford
Query!
Country [258]
0
0
Germany
Query!
State/province [258]
0
0
Homburg/Saar
Query!
Country [259]
0
0
Germany
Query!
State/province [259]
0
0
Jena
Query!
Country [260]
0
0
Germany
Query!
State/province [260]
0
0
Julich
Query!
Country [261]
0
0
Germany
Query!
State/province [261]
0
0
Kamen
Query!
Country [262]
0
0
Germany
Query!
State/province [262]
0
0
Karlsbad
Query!
Country [263]
0
0
Germany
Query!
State/province [263]
0
0
Kassel
Query!
Country [264]
0
0
Germany
Query!
State/province [264]
0
0
Kirchzarten
Query!
Country [265]
0
0
Germany
Query!
State/province [265]
0
0
Krefeld
Query!
Country [266]
0
0
Germany
Query!
State/province [266]
0
0
Leipzig
Query!
Country [267]
0
0
Germany
Query!
State/province [267]
0
0
Ludwigsburg
Query!
Country [268]
0
0
Germany
Query!
State/province [268]
0
0
Ludwigshafen
Query!
Country [269]
0
0
Germany
Query!
State/province [269]
0
0
Lüneburg
Query!
Country [270]
0
0
Germany
Query!
State/province [270]
0
0
Magdeburg
Query!
Country [271]
0
0
Germany
Query!
State/province [271]
0
0
Mainz
Query!
Country [272]
0
0
Germany
Query!
State/province [272]
0
0
Mannheim
Query!
Country [273]
0
0
Germany
Query!
State/province [273]
0
0
Markkleeberg
Query!
Country [274]
0
0
Germany
Query!
State/province [274]
0
0
Meißen
Query!
Country [275]
0
0
Germany
Query!
State/province [275]
0
0
Melsungen
Query!
Country [276]
0
0
Germany
Query!
State/province [276]
0
0
Monchengladbach
Query!
Country [277]
0
0
Germany
Query!
State/province [277]
0
0
Munchen
Query!
Country [278]
0
0
Germany
Query!
State/province [278]
0
0
Mühldorf
Query!
Country [279]
0
0
Germany
Query!
State/province [279]
0
0
Mülheim
Query!
Country [280]
0
0
Germany
Query!
State/province [280]
0
0
Münster
Query!
Country [281]
0
0
Germany
Query!
State/province [281]
0
0
Neuwied
Query!
Country [282]
0
0
Germany
Query!
State/province [282]
0
0
Nienburg
Query!
Country [283]
0
0
Germany
Query!
State/province [283]
0
0
Nuernberg
Query!
Country [284]
0
0
Germany
Query!
State/province [284]
0
0
Paderborn
Query!
Country [285]
0
0
Germany
Query!
State/province [285]
0
0
Potsdam
Query!
Country [286]
0
0
Germany
Query!
State/province [286]
0
0
Riesa
Query!
Country [287]
0
0
Germany
Query!
State/province [287]
0
0
Rottweil
Query!
Country [288]
0
0
Germany
Query!
State/province [288]
0
0
Sachsen
Query!
Country [289]
0
0
Germany
Query!
State/province [289]
0
0
Siegen
Query!
Country [290]
0
0
Germany
Query!
State/province [290]
0
0
Ulm
Query!
Country [291]
0
0
Germany
Query!
State/province [291]
0
0
Wermsdorf
Query!
Country [292]
0
0
Germany
Query!
State/province [292]
0
0
Witten
Query!
Country [293]
0
0
Germany
Query!
State/province [293]
0
0
Wolmirstedt
Query!
Country [294]
0
0
Germany
Query!
State/province [294]
0
0
Wuppertal
Query!
Country [295]
0
0
Greece
Query!
State/province [295]
0
0
Athens Attica
Query!
Country [296]
0
0
Greece
Query!
State/province [296]
0
0
Ioannina
Query!
Country [297]
0
0
Greece
Query!
State/province [297]
0
0
Maroussi Athens
Query!
Country [298]
0
0
Greece
Query!
State/province [298]
0
0
Patra
Query!
Country [299]
0
0
Greece
Query!
State/province [299]
0
0
Piraeus Attica
Query!
Country [300]
0
0
Greece
Query!
State/province [300]
0
0
Tripoli
Query!
Country [301]
0
0
Greece
Query!
State/province [301]
0
0
Voula Attica
Query!
Country [302]
0
0
Hong Kong
Query!
State/province [302]
0
0
Aberdeen
Query!
Country [303]
0
0
Hong Kong
Query!
State/province [303]
0
0
Hk
Query!
Country [304]
0
0
Hong Kong
Query!
State/province [304]
0
0
Kln
Query!
Country [305]
0
0
Hong Kong
Query!
State/province [305]
0
0
Sha Tin
Query!
Country [306]
0
0
Hungary
Query!
State/province [306]
0
0
Budapest N/A
Query!
Country [307]
0
0
Hungary
Query!
State/province [307]
0
0
Budapest Nap
Query!
Country [308]
0
0
Hungary
Query!
State/province [308]
0
0
Budapest
Query!
Country [309]
0
0
Hungary
Query!
State/province [309]
0
0
Debrecen County
Query!
Country [310]
0
0
Hungary
Query!
State/province [310]
0
0
Eger
Query!
Country [311]
0
0
Hungary
Query!
State/province [311]
0
0
Gyongyos
Query!
Country [312]
0
0
Hungary
Query!
State/province [312]
0
0
Gyõr
Query!
Country [313]
0
0
Hungary
Query!
State/province [313]
0
0
Kesckemet
Query!
Country [314]
0
0
Hungary
Query!
State/province [314]
0
0
Miskolc
Query!
Country [315]
0
0
Hungary
Query!
State/province [315]
0
0
Nyiregyhaza
Query!
Country [316]
0
0
Hungary
Query!
State/province [316]
0
0
Pecs
Query!
Country [317]
0
0
Hungary
Query!
State/province [317]
0
0
Szeged
Query!
Country [318]
0
0
Hungary
Query!
State/province [318]
0
0
Szekszard
Query!
Country [319]
0
0
Hungary
Query!
State/province [319]
0
0
Szombathely
Query!
Country [320]
0
0
Hungary
Query!
State/province [320]
0
0
Veszprem
Query!
Country [321]
0
0
Hungary
Query!
State/province [321]
0
0
Zalaegerszeg
Query!
Country [322]
0
0
India
Query!
State/province [322]
0
0
Ahmedabad
Query!
Country [323]
0
0
India
Query!
State/province [323]
0
0
Bangalore
Query!
Country [324]
0
0
India
Query!
State/province [324]
0
0
Bikaner
Query!
Country [325]
0
0
India
Query!
State/province [325]
0
0
Chennai
Query!
Country [326]
0
0
India
Query!
State/province [326]
0
0
Coimbatore
Query!
Country [327]
0
0
India
Query!
State/province [327]
0
0
Gandhinagar Guiarat
Query!
Country [328]
0
0
India
Query!
State/province [328]
0
0
Hyderabad Andra Pradesh
Query!
Country [329]
0
0
India
Query!
State/province [329]
0
0
Hyderabad
Query!
Country [330]
0
0
India
Query!
State/province [330]
0
0
Jalandhar
Query!
Country [331]
0
0
India
Query!
State/province [331]
0
0
Madurai
Query!
Country [332]
0
0
India
Query!
State/province [332]
0
0
Mangalore
Query!
Country [333]
0
0
India
Query!
State/province [333]
0
0
Mumbai
Query!
Country [334]
0
0
India
Query!
State/province [334]
0
0
Mysore
Query!
Country [335]
0
0
India
Query!
State/province [335]
0
0
New Delhi
Query!
Country [336]
0
0
India
Query!
State/province [336]
0
0
Pune
Query!
Country [337]
0
0
India
Query!
State/province [337]
0
0
Suraj
Query!
Country [338]
0
0
India
Query!
State/province [338]
0
0
Vadodara
Query!
Country [339]
0
0
India
Query!
State/province [339]
0
0
Vishakapatnam
Query!
Country [340]
0
0
Israel
Query!
State/province [340]
0
0
Afula
Query!
Country [341]
0
0
Israel
Query!
State/province [341]
0
0
Ashkelon
Query!
Country [342]
0
0
Israel
Query!
State/province [342]
0
0
Hadera
Query!
Country [343]
0
0
Israel
Query!
State/province [343]
0
0
Haifa
Query!
Country [344]
0
0
Israel
Query!
State/province [344]
0
0
Holon
Query!
Country [345]
0
0
Israel
Query!
State/province [345]
0
0
Jerusalem
Query!
Country [346]
0
0
Israel
Query!
State/province [346]
0
0
Nazareth
Query!
Country [347]
0
0
Israel
Query!
State/province [347]
0
0
Netanya
Query!
Country [348]
0
0
Israel
Query!
State/province [348]
0
0
Petach-Tikva
Query!
Country [349]
0
0
Israel
Query!
State/province [349]
0
0
Petah-Tikva
Query!
Country [350]
0
0
Israel
Query!
State/province [350]
0
0
Poriya
Query!
Country [351]
0
0
Israel
Query!
State/province [351]
0
0
Rehovot
Query!
Country [352]
0
0
Israel
Query!
State/province [352]
0
0
Safed
Query!
Country [353]
0
0
Israel
Query!
State/province [353]
0
0
Tel Aviv
Query!
Country [354]
0
0
Israel
Query!
State/province [354]
0
0
Tel Hashomer
Query!
Country [355]
0
0
Israel
Query!
State/province [355]
0
0
Zerifin
Query!
Country [356]
0
0
Korea, Republic of
Query!
State/province [356]
0
0
Anyang
Query!
Country [357]
0
0
Korea, Republic of
Query!
State/province [357]
0
0
Daegu
Query!
Country [358]
0
0
Korea, Republic of
Query!
State/province [358]
0
0
Daejeon
Query!
Country [359]
0
0
Korea, Republic of
Query!
State/province [359]
0
0
Goyang
Query!
Country [360]
0
0
Korea, Republic of
Query!
State/province [360]
0
0
Kyonggi-Do
Query!
Country [361]
0
0
Korea, Republic of
Query!
State/province [361]
0
0
Pusan
Query!
Country [362]
0
0
Korea, Republic of
Query!
State/province [362]
0
0
Seoul
Query!
Country [363]
0
0
Korea, Republic of
Query!
State/province [363]
0
0
Sungnam
Query!
Country [364]
0
0
Korea, Republic of
Query!
State/province [364]
0
0
Suwon
Query!
Country [365]
0
0
Lithuania
Query!
State/province [365]
0
0
Kaunas
Query!
Country [366]
0
0
Lithuania
Query!
State/province [366]
0
0
Klaipeda
Query!
Country [367]
0
0
Lithuania
Query!
State/province [367]
0
0
Panevezys
Query!
Country [368]
0
0
Lithuania
Query!
State/province [368]
0
0
Siauliai
Query!
Country [369]
0
0
Lithuania
Query!
State/province [369]
0
0
Vilnius
Query!
Country [370]
0
0
Malaysia
Query!
State/province [370]
0
0
Kelantan
Query!
Country [371]
0
0
Malaysia
Query!
State/province [371]
0
0
Kuala Lumpur
Query!
Country [372]
0
0
Malaysia
Query!
State/province [372]
0
0
Sarawak
Query!
Country [373]
0
0
Mexico
Query!
State/province [373]
0
0
Aguascalientes
Query!
Country [374]
0
0
Mexico
Query!
State/province [374]
0
0
Ciudad De Mexico
Query!
Country [375]
0
0
Mexico
Query!
State/province [375]
0
0
Culiacán Sinaloa/Mèxico
Query!
Country [376]
0
0
Mexico
Query!
State/province [376]
0
0
Guadalajara
Query!
Country [377]
0
0
Mexico
Query!
State/province [377]
0
0
Hermosillo
Query!
Country [378]
0
0
Mexico
Query!
State/province [378]
0
0
Monterrey Nuevo Leòn
Query!
Country [379]
0
0
Mexico
Query!
State/province [379]
0
0
Monterrey
Query!
Country [380]
0
0
Mexico
Query!
State/province [380]
0
0
Queretaro
Query!
Country [381]
0
0
Mexico
Query!
State/province [381]
0
0
San Luis Potosi
Query!
Country [382]
0
0
Mexico
Query!
State/province [382]
0
0
Sinaloa
Query!
Country [383]
0
0
Mexico
Query!
State/province [383]
0
0
Zapopan
Query!
Country [384]
0
0
Netherlands
Query!
State/province [384]
0
0
'S-Gravenhage
Query!
Country [385]
0
0
Netherlands
Query!
State/province [385]
0
0
Alkmaar
Query!
Country [386]
0
0
Netherlands
Query!
State/province [386]
0
0
Amersfoort
Query!
Country [387]
0
0
Netherlands
Query!
State/province [387]
0
0
Amsterdam
Query!
Country [388]
0
0
Netherlands
Query!
State/province [388]
0
0
Blaricum
Query!
Country [389]
0
0
Netherlands
Query!
State/province [389]
0
0
Delft
Query!
Country [390]
0
0
Netherlands
Query!
State/province [390]
0
0
Den Bosch
Query!
Country [391]
0
0
Netherlands
Query!
State/province [391]
0
0
Den Haag
Query!
Country [392]
0
0
Netherlands
Query!
State/province [392]
0
0
Gc Tilburg
Query!
Country [393]
0
0
Netherlands
Query!
State/province [393]
0
0
Gouda
Query!
Country [394]
0
0
Netherlands
Query!
State/province [394]
0
0
Groningen
Query!
Country [395]
0
0
Netherlands
Query!
State/province [395]
0
0
Haarlem
Query!
Country [396]
0
0
Netherlands
Query!
State/province [396]
0
0
Heerlen
Query!
Country [397]
0
0
Netherlands
Query!
State/province [397]
0
0
Hoofddorp
Query!
Country [398]
0
0
Netherlands
Query!
State/province [398]
0
0
Hoorn Nh
Query!
Country [399]
0
0
Netherlands
Query!
State/province [399]
0
0
Leeuwarden
Query!
Country [400]
0
0
Netherlands
Query!
State/province [400]
0
0
Leidschendam
Query!
Country [401]
0
0
Netherlands
Query!
State/province [401]
0
0
Maastricht
Query!
Country [402]
0
0
Netherlands
Query!
State/province [402]
0
0
Meppel
Query!
Country [403]
0
0
Netherlands
Query!
State/province [403]
0
0
Nijmegen
Query!
Country [404]
0
0
Netherlands
Query!
State/province [404]
0
0
Schiedam
Query!
Country [405]
0
0
Netherlands
Query!
State/province [405]
0
0
Veldhoven
Query!
Country [406]
0
0
New Zealand
Query!
State/province [406]
0
0
Christchurch
Query!
Country [407]
0
0
New Zealand
Query!
State/province [407]
0
0
Dunedin
Query!
Country [408]
0
0
New Zealand
Query!
State/province [408]
0
0
Grafton
Query!
Country [409]
0
0
New Zealand
Query!
State/province [409]
0
0
Hamilton
Query!
Country [410]
0
0
New Zealand
Query!
State/province [410]
0
0
Takapuna Auckland
Query!
Country [411]
0
0
New Zealand
Query!
State/province [411]
0
0
Wellington
Query!
Country [412]
0
0
Norway
Query!
State/province [412]
0
0
Alesund
Query!
Country [413]
0
0
Norway
Query!
State/province [413]
0
0
Bergen
Query!
Country [414]
0
0
Norway
Query!
State/province [414]
0
0
Elverum
Query!
Country [415]
0
0
Norway
Query!
State/province [415]
0
0
Hamar
Query!
Country [416]
0
0
Norway
Query!
State/province [416]
0
0
Jessheim
Query!
Country [417]
0
0
Norway
Query!
State/province [417]
0
0
Lillehammer
Query!
Country [418]
0
0
Norway
Query!
State/province [418]
0
0
Moss
Query!
Country [419]
0
0
Norway
Query!
State/province [419]
0
0
Oslo
Query!
Country [420]
0
0
Norway
Query!
State/province [420]
0
0
Sandefjord
Query!
Country [421]
0
0
Norway
Query!
State/province [421]
0
0
Sandnes
Query!
Country [422]
0
0
Norway
Query!
State/province [422]
0
0
Sandvika
Query!
Country [423]
0
0
Norway
Query!
State/province [423]
0
0
Skedsmokorset
Query!
Country [424]
0
0
Peru
Query!
State/province [424]
0
0
L41 Lima Lima
Query!
Country [425]
0
0
Peru
Query!
State/province [425]
0
0
Lima 1 Lima Lima
Query!
Country [426]
0
0
Peru
Query!
State/province [426]
0
0
Lima
Query!
Country [427]
0
0
Philippines
Query!
State/province [427]
0
0
Cebuu City
Query!
Country [428]
0
0
Philippines
Query!
State/province [428]
0
0
Davao City
Query!
Country [429]
0
0
Philippines
Query!
State/province [429]
0
0
Iloilo City
Query!
Country [430]
0
0
Philippines
Query!
State/province [430]
0
0
Manila City
Query!
Country [431]
0
0
Philippines
Query!
State/province [431]
0
0
Quezon City
Query!
Country [432]
0
0
Poland
Query!
State/province [432]
0
0
Bydgoszcz N/A
Query!
Country [433]
0
0
Poland
Query!
State/province [433]
0
0
Bydgoszcz
Query!
Country [434]
0
0
Poland
Query!
State/province [434]
0
0
Gdansk
Query!
Country [435]
0
0
Poland
Query!
State/province [435]
0
0
Gdynia
Query!
Country [436]
0
0
Poland
Query!
State/province [436]
0
0
Katowice-Ochojec
Query!
Country [437]
0
0
Poland
Query!
State/province [437]
0
0
Katowice
Query!
Country [438]
0
0
Poland
Query!
State/province [438]
0
0
Krakow
Query!
Country [439]
0
0
Poland
Query!
State/province [439]
0
0
Lodz
Query!
Country [440]
0
0
Poland
Query!
State/province [440]
0
0
Olawa
Query!
Country [441]
0
0
Poland
Query!
State/province [441]
0
0
Olsztyn
Query!
Country [442]
0
0
Poland
Query!
State/province [442]
0
0
Opole
Query!
Country [443]
0
0
Poland
Query!
State/province [443]
0
0
Ostrowiec N/A
Query!
Country [444]
0
0
Poland
Query!
State/province [444]
0
0
Piotrkow Trybunalski
Query!
Country [445]
0
0
Poland
Query!
State/province [445]
0
0
Plock
Query!
Country [446]
0
0
Poland
Query!
State/province [446]
0
0
Poznan
Query!
Country [447]
0
0
Poland
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State/province [447]
0
0
Siedlce
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0
0
Poland
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State/province [448]
0
0
Sieradz N/A
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Country [449]
0
0
Poland
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State/province [449]
0
0
Skierniewice
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Country [450]
0
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Poland
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0
Starogard Gdanski Nap
Query!
Country [451]
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0
Poland
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State/province [451]
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0
Szczecin Nap
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Poland
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Szczecin
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Poland
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0
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Torun
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Country [454]
0
0
Poland
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0
0
Warsaw
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Poland
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0
Warszawa N/A
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Warszawa
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Poland
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0
Wloclawek
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Poland
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Wroclaw N/A
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Poland
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State/province [459]
0
0
Wroclaw
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Country [460]
0
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Poland
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0
0
Zyrardow N/A
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Country [461]
0
0
Romania
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State/province [461]
0
0
Brasov
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Country [462]
0
0
Romania
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State/province [462]
0
0
Bucharest
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Country [463]
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0
Romania
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0
Bucuresti
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Country [464]
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0
Romania
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0
Craiova
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Country [465]
0
0
Romania
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0
0
Focsani
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Country [466]
0
0
Romania
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0
0
Iasi
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Country [467]
0
0
Romania
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0
0
Oradea
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Country [468]
0
0
Romania
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State/province [468]
0
0
Sibiu
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Country [469]
0
0
Romania
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State/province [469]
0
0
Suceava
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Country [470]
0
0
Romania
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State/province [470]
0
0
Tg Mures
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Country [471]
0
0
Romania
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0
0
Timisoara
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Country [472]
0
0
Russian Federation
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0
0
Barnaul
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Country [473]
0
0
Russian Federation
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0
0
Chelyabinsk Chelyabinsk Region
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Country [474]
0
0
Russian Federation
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State/province [474]
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0
Chelyabinsk
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0
Russian Federation
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0
Ekaterinburg
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0
0
Russian Federation
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State/province [476]
0
0
Kemerovo
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Country [477]
0
0
Russian Federation
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0
0
Krasnoyarsk
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Country [478]
0
0
Russian Federation
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State/province [478]
0
0
Moscow N/A
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Country [479]
0
0
Russian Federation
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State/province [479]
0
0
Moscow
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Country [480]
0
0
Russian Federation
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State/province [480]
0
0
Nizhni Novgorod
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0
0
Russian Federation
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State/province [481]
0
0
Novosibirsk Nap
Query!
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0
0
Russian Federation
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0
0
Novosibirsk
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0
0
Russian Federation
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0
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Orenburg
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0
0
Russian Federation
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0
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Perm
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0
0
Russian Federation
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Ryazan
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Country [486]
0
0
Russian Federation
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Saint Petersburg
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Country [487]
0
0
Russian Federation
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State/province [487]
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Saint-Petersburg
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Russian Federation
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Saratov
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0
0
Russian Federation
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0
Smolensk
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Country [490]
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0
Russian Federation
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State/province [490]
0
0
St Petersburg
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Country [491]
0
0
Russian Federation
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State/province [491]
0
0
St. Petersburg
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Country [492]
0
0
Russian Federation
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0
Tomsk
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Country [493]
0
0
Russian Federation
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State/province [493]
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0
Tyumen Tyumen Region
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Russian Federation
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Yaroslavl Nap
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Russian Federation
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Yaroslavl
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Singapore
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Singapore
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South Africa
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Bloemfontein Free State
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South Africa
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Bloemfontein Orange Free State
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South Africa
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Cape Town Western Cape
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South Africa
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Cape Town
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South Africa
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Centurion Gauteng
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South Africa
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Durban Kwa Zulu Natal
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South Africa
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Johannesburg Gauteng
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South Africa
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Kempton Park Gauteng
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South Africa
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Port Elizabeth Eastern Cape
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0
South Africa
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0
0
Pretoria Gauteng
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0
South Africa
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0
0
Somerset West Western Cape
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0
0
South Africa
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State/province [508]
0
0
Van Der Bijl Park
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0
0
South Africa
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State/province [509]
0
0
Worcester Western Cape
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0
Spain
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State/province [510]
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0
A Coruna
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Spain
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0
Alicante N/A
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0
Spain
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Almeria
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Spain
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0
Baracaldo Vizcaya
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Spain
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Barcelona
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Spain
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Burgos
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Spain
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Guadalajara
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Spain
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La Corona
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0
Spain
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Madrid
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Spain
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Malaga
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0
Spain
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Oviedo
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Spain
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Palma De Mallorca
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Spain
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Pamplona
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0
Spain
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Pontevedra
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0
Spain
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Sabadell
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0
Spain
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0
San Sebastián Guipúzcoa
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0
Spain
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Sevilla
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0
Spain
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0
Terrassa
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0
Spain
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Valencia
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0
Spain
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0
Valladolid
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0
0
Sweden
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0
Ljungby
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0
Sweden
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Lund
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0
0
Sweden
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0
Sala
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0
0
Sweden
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0
Skövde
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0
0
Sweden
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Uppsala
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0
Switzerland
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0
Basel Bs
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0
Switzerland
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Bruderholz
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0
Switzerland
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Geneve
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0
Switzerland
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0
Zurich
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0
0
Taiwan
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0
0
Changhua
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Country [540]
0
0
Taiwan
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0
0
Kaohsiung
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0
0
Taiwan
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0
0
Taichung
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0
0
Taiwan
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0
Tainan
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0
0
Taiwan
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0
0
Taipei
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Country [544]
0
0
Taiwan
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0
0
Tamshui
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0
Taiwan
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0
Tao-Yuan
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0
Thailand
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0
Bangkok Noi
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0
0
Thailand
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0
0
Bangkok
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0
0
Thailand
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0
0
Chiang Mai
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Country [549]
0
0
Thailand
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0
0
Pathumthani
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Country [550]
0
0
Thailand
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0
0
Phathumwan
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Country [551]
0
0
Thailand
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State/province [551]
0
0
Ratchatewi
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Country [552]
0
0
Turkey
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0
0
Adana
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Country [553]
0
0
Turkey
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0
0
Ankara
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0
0
Turkey
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0
0
Antalya
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Country [555]
0
0
Turkey
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0
0
Aydin
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Country [556]
0
0
Turkey
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0
0
Denizli
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0
0
Turkey
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0
0
Diyarbakir
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0
0
Turkey
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0
0
Eskisehir
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Country [559]
0
0
Turkey
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State/province [559]
0
0
Görükle
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Country [560]
0
0
Turkey
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0
0
Istanbul
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Country [561]
0
0
Turkey
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0
0
Izmir
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Country [562]
0
0
Turkey
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0
0
Izmit
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Country [563]
0
0
Turkey
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State/province [563]
0
0
Kayseri
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Country [564]
0
0
Turkey
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0
0
Konya
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Country [565]
0
0
Turkey
Query!
State/province [565]
0
0
Malatya Nap
Query!
Country [566]
0
0
Turkey
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State/province [566]
0
0
Mersin
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Country [567]
0
0
Turkey
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State/province [567]
0
0
Samsun
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Country [568]
0
0
Ukraine
Query!
State/province [568]
0
0
Cherkassy
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Country [569]
0
0
Ukraine
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State/province [569]
0
0
Chernigiv
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Country [570]
0
0
Ukraine
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State/province [570]
0
0
Dnepropetrovsk
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Country [571]
0
0
Ukraine
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State/province [571]
0
0
Dnipropetrovsk
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Country [572]
0
0
Ukraine
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State/province [572]
0
0
Donetsk
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Country [573]
0
0
Ukraine
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State/province [573]
0
0
Ivano-Frankivsk
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Country [574]
0
0
Ukraine
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State/province [574]
0
0
Kharkiv
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Country [575]
0
0
Ukraine
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State/province [575]
0
0
Kharkov
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Country [576]
0
0
Ukraine
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State/province [576]
0
0
Kirovograd
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Country [577]
0
0
Ukraine
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State/province [577]
0
0
Kyiv
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Country [578]
0
0
Ukraine
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State/province [578]
0
0
Lugansk
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Country [579]
0
0
Ukraine
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State/province [579]
0
0
Lviv
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Country [580]
0
0
Ukraine
Query!
State/province [580]
0
0
O1103 Kyiv
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Country [581]
0
0
Ukraine
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State/province [581]
0
0
Odesa
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Country [582]
0
0
Ukraine
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State/province [582]
0
0
Poltava
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Country [583]
0
0
Ukraine
Query!
State/province [583]
0
0
Simferopil
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Country [584]
0
0
Ukraine
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State/province [584]
0
0
Sumy
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Country [585]
0
0
Ukraine
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State/province [585]
0
0
Ternopil
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Country [586]
0
0
Ukraine
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State/province [586]
0
0
Uzhgorod
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Country [587]
0
0
Ukraine
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State/province [587]
0
0
Vinnitsya
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Country [588]
0
0
Ukraine
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State/province [588]
0
0
Vinnytsia
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Country [589]
0
0
Ukraine
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State/province [589]
0
0
Zaporizhzhya
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Country [590]
0
0
Ukraine
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State/province [590]
0
0
Zhytomyr
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Country [591]
0
0
United Kingdom
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State/province [591]
0
0
Aberdeen
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Country [592]
0
0
United Kingdom
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State/province [592]
0
0
Belfast
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Country [593]
0
0
United Kingdom
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State/province [593]
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0
Birmingham
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Country [594]
0
0
United Kingdom
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State/province [594]
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0
Bournemouth
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Country [595]
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0
United Kingdom
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0
Cambridgeshire
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Country [596]
0
0
United Kingdom
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State/province [596]
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0
Chelmsford
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Country [597]
0
0
United Kingdom
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State/province [597]
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0
Chesterfield
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Country [598]
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0
United Kingdom
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State/province [598]
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0
Colchester
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Country [599]
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0
United Kingdom
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State/province [599]
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0
Craigavon
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Country [600]
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0
United Kingdom
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0
Devon
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Country [601]
0
0
United Kingdom
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State/province [601]
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0
Dundee
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Country [602]
0
0
United Kingdom
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0
0
Glasgow
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Country [603]
0
0
United Kingdom
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State/province [603]
0
0
Harrogate
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Country [604]
0
0
United Kingdom
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State/province [604]
0
0
Hull
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Country [605]
0
0
United Kingdom
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State/province [605]
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0
Leicester
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Country [606]
0
0
United Kingdom
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State/province [606]
0
0
Lincoln
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Country [607]
0
0
United Kingdom
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State/province [607]
0
0
Liverpool
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Country [608]
0
0
United Kingdom
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State/province [608]
0
0
London
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Country [609]
0
0
United Kingdom
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State/province [609]
0
0
Nottingham
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Country [610]
0
0
United Kingdom
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State/province [610]
0
0
Plymouth
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Country [611]
0
0
United Kingdom
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State/province [611]
0
0
Romford
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Country [612]
0
0
United Kingdom
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State/province [612]
0
0
Sheffield
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Country [613]
0
0
United Kingdom
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State/province [613]
0
0
Stirling
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Country [614]
0
0
United Kingdom
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State/province [614]
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0
Stoke On Trent
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Country [615]
0
0
United Kingdom
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State/province [615]
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0
York
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Country [616]
0
0
Venezuela
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State/province [616]
0
0
Caracas
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Country [617]
0
0
Venezuela
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State/province [617]
0
0
Maracaibo Estado Zulia
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Country [618]
0
0
Venezuela
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State/province [618]
0
0
Maracay Estado Aragua
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Funding & Sponsors
Primary sponsor type
Commercial sector/industry
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Name
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
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Address
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Country
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Other collaborator category [1]
0
0
Commercial sector/industry
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Name [1]
0
0
Bayer
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Address [1]
0
0
Query!
Country [1]
0
0
Query!
Ethics approval
Ethics application status
Query!
Summary
Brief summary
The purpose of this study is to compare the efficacy and safety of rivaroxaban with warfarin for the prevention of blood clots in the brain (referred to as stroke) and blood clots in other parts of the body referred to as non-central nervous system systemic embolism) in patients with non-valvular atrial fibrillation (a heart rhythm disorder).
Query!
Trial website
https://clinicaltrials.gov/study/NCT00403767
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Trial related presentations / publications
Ungar L, Rodriguez F, Hellkamp AS, Becker RC, Berkowitz SD, Breithardt G, Fox KAA, Hacke W, Halperin JL, Hankey GJ, Nessel CC, Singer DE, Patel MR, Piccini JP, Mahaffey KW. Patient-Reported Satisfaction and Study Drug Discontinuation: Post-Hoc Analysis of Findings from ROCKET AF. Cardiol Ther. 2019 Dec;8(2):283-295. doi: 10.1007/s40119-019-00146-6. Epub 2019 Aug 2. Quinn GR, Hellkamp AS, Hankey GJ, Becker RC, Berkowitz SD, Breithardt G, Fava M, Fox KAA, Halperin JL, Mahaffey KW, Nessel CC, Patel MR, Piccini JP, Singer DE. Selective Serotonin Reuptake Inhibitors and Bleeding Risk in Anticoagulated Patients With Atrial Fibrillation: An Analysis From the ROCKET AF Trial. J Am Heart Assoc. 2018 Aug 7;7(15):e008755. doi: 10.1161/JAHA.118.008755. Chen ST, Hellkamp AS, Becker RC, Berkowitz SD, Breithardt G, Fox KAA, Hacke W, Halperin JL, Hankey GJ, Mahaffey KW, Nessel CC, Piccini JP, Singer DE, Patel MR, Melloni C. Efficacy and safety of rivaroxaban vs. warfarin in patients with non-valvular atrial fibrillation and a history of cancer: observations from ROCKET AF. Eur Heart J Qual Care Clin Outcomes. 2019 Apr 1;5(2):145-152. doi: 10.1093/ehjqcco/qcy040. Chen ST, Hellkamp AS, Becker RC, Berkowitz SD, Breithardt G, Fox KAA, Hacke W, Halperin JL, Hankey GJ, Mahaffey KW, Nessel CC, Piccini JP, Singer DE, Patel MR. Impact of polyvascular disease on patients with atrial fibrillation: Insights from ROCKET AF. Am Heart J. 2018 Jun;200:102-109. doi: 10.1016/j.ahj.2018.02.013. Epub 2018 Feb 27. Leef GC, Hellkamp AS, Patel MR, Becker RC, Berkowitz SD, Breithardt G, Halperin JL, Hankey GJ, Hacke W, Nessel CC, Singer DE, Fox KAA, Mahaffey KW, Piccini JP. Safety and Efficacy of Rivaroxaban in Patients With Cardiac Implantable Electronic Devices: Observations From the ROCKET AF Trial. J Am Heart Assoc. 2017 Jun 14;6(6):e004663. doi: 10.1161/JAHA.116.004663. Balla SR, Cyr DD, Lokhnygina Y, Becker RC, Berkowitz SD, Breithardt G, Fox KAA, Hacke W, Halperin JL, Hankey GJ, Mahaffey KW, Nessel CC, Piccini JP, Singer DE, Patel MR. Relation of Risk of Stroke in Patients With Atrial Fibrillation to Body Mass Index (from Patients Treated With Rivaroxaban and Warfarin in the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation Trial). Am J Cardiol. 2017 Jun 15;119(12):1989-1996. doi: 10.1016/j.amjcard.2017.03.028. Epub 2017 Mar 29. Sun Y, Hu D, Stevens S, Lokhnygina Y, Becker RC, Berkowitz SD, Breithardt G, Hacke W, Halperin JL, Hankey GJ, Mahaffey KW, Nessel CC, Piccini JP, Singer DE, Fox KAA, Patel MR. Efficacy and safety of rivaroxaban versus warfarin in patients from mainland China with nonvalvular atrial fibrillation: A subgroup analysis from the ROCKET AF trial. Thromb Res. 2017 Aug;156:184-190. doi: 10.1016/j.thromres.2017.04.010. Epub 2017 Apr 13. Lindner SM, Fordyce CB, Hellkamp AS, Lokhnygina Y, Piccini JP, Breithardt G, Mahaffey KW, Singer DE, Hacke W, Halperin JL, Hankey GJ, Berkowitz SD, Nessel CC, Becker RC, Fox KA, Patel MR; ROCKET AF Steering Committee and Investigators. Treatment Consistency Across Levels of Baseline Renal Function With Rivaroxaban or Warfarin: A ROCKET AF (Rivaroxaban Once-Daily, Oral, Direct Factor Xa Inhibition Compared With Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation) Analysis. Circulation. 2017 Mar 7;135(10):1001-1003. doi: 10.1161/CIRCULATIONAHA.116.024666. No abstract available. Fordyce CB, Hellkamp AS, Lokhnygina Y, Lindner SM, Piccini JP, Becker RC, Berkowitz SD, Breithardt G, Fox KA, Mahaffey KW, Nessel CC, Singer DE, Patel MR; ROCKET AF Steering Committee and Investigators. On-Treatment Outcomes in Patients With Worsening Renal Function With Rivaroxaban Compared With Warfarin: Insights From ROCKET AF. Circulation. 2016 Jul 5;134(1):37-47. doi: 10.1161/CIRCULATIONAHA.116.021890. Erratum In: Circulation. 2016 Aug 23;134(8):e114. doi: 10.1161/CIR.0000000000000451. Circulation. 2020 Feb 25;141(8):e98. doi: 10.1161/CIR.0000000000000763. Pokorney SD, Piccini JP, Stevens SR, Patel MR, Pieper KS, Halperin JL, Breithardt G, Singer DE, Hankey GJ, Hacke W, Becker RC, Berkowitz SD, Nessel CC, Mahaffey KW, Fox KA, Califf RM; ROCKET AF Steering Committee & Investigators; ROCKET AF Steering Committee Investigators. Cause of Death and Predictors of All-Cause Mortality in Anticoagulated Patients With Nonvalvular Atrial Fibrillation: Data From ROCKET AF. J Am Heart Assoc. 2016 Mar 8;5(3):e002197. doi: 10.1161/JAHA.115.002197. Breithardt G, Baumgartner H, Berkowitz SD, Hellkamp AS, Piccini JP, Lokhnygina Y, Halperin JL, Singer DE, Hankey GJ, Hacke W, Becker RC, Nessel CC, Mahaffey KW, Califf RM, Fox KA, Patel MR; ROCKET AF Steering Committee & Investigators. Native valve disease in patients with non-valvular atrial fibrillation on warfarin or rivaroxaban. Heart. 2016 Jul 1;102(13):1036-43. doi: 10.1136/heartjnl-2015-308120. Epub 2016 Feb 17. Piccini JP, Hellkamp AS, Washam JB, Becker RC, Breithardt G, Berkowitz SD, Halperin JL, Hankey GJ, Hacke W, Mahaffey KW, Nessel CC, Singer DE, Fox KA, Patel MR. Polypharmacy and the Efficacy and Safety of Rivaroxaban Versus Warfarin in the Prevention of Stroke in Patients With Nonvalvular Atrial Fibrillation. Circulation. 2016 Jan 26;133(4):352-60. doi: 10.1161/CIRCULATIONAHA.115.018544. Epub 2015 Dec 16. Bansilal S, Bloomgarden Z, Halperin JL, Hellkamp AS, Lokhnygina Y, Patel MR, Becker RC, Breithardt G, Hacke W, Hankey GJ, Nessel CC, Singer DE, Berkowitz SD, Piccini JP, Mahaffey KW, Fox KA; ROCKET AF Steering Committee and Investigators. Efficacy and safety of rivaroxaban in patients with diabetes and nonvalvular atrial fibrillation: the Rivaroxaban Once-daily, Oral, Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF Trial). Am Heart J. 2015 Oct;170(4):675-682.e8. doi: 10.1016/j.ahj.2015.07.006. Epub 2015 Jul 17. Washam JB, Stevens SR, Lokhnygina Y, Halperin JL, Breithardt G, Singer DE, Mahaffey KW, Hankey GJ, Berkowitz SD, Nessel CC, Fox KA, Califf RM, Piccini JP, Patel MR; ROCKET AF Steering Committee and Investigators. Digoxin use in patients with atrial fibrillation and adverse cardiovascular outcomes: a retrospective analysis of the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF). Lancet. 2015 Jun 13;385(9985):2363-70. doi: 10.1016/S0140-6736(14)61836-5. Epub 2015 Mar 6. Singer DE, Hellkamp AS, Yuan Z, Lokhnygina Y, Patel MR, Piccini JP, Hankey GJ, Breithardt G, Halperin JL, Becker RC, Hacke W, Nessel CC, Mahaffey KW, Fox KA, Califf RM; ROCKET AF Investigators. Alternative calculations of individual patient time in therapeutic range while taking warfarin: results from the ROCKET AF trial. J Am Heart Assoc. 2015 Mar 3;4(3):e001349. doi: 10.1161/JAHA.114.001349. Girgis IG, Patel MR, Peters GR, Moore KT, Mahaffey KW, Nessel CC, Halperin JL, Califf RM, Fox KA, Becker RC. Population pharmacokinetics and pharmacodynamics of rivaroxaban in patients with non-valvular atrial fibrillation: results from ROCKET AF. J Clin Pharmacol. 2014 Aug;54(8):917-27. doi: 10.1002/jcph.288. Epub 2014 Mar 26. Sherwood MW, Douketis JD, Patel MR, Piccini JP, Hellkamp AS, Lokhnygina Y, Spyropoulos AC, Hankey GJ, Singer DE, Nessel CC, Mahaffey KW, Fox KA, Califf RM, Becker RC; ROCKET AF Investigators. Outcomes of temporary interruption of rivaroxaban compared with warfarin in patients with nonvalvular atrial fibrillation: results from the rivaroxaban once daily, oral, direct factor Xa inhibition compared with vitamin K antagonism for prevention of stroke and embolism trial in atrial fibrillation (ROCKET AF). Circulation. 2014 May 6;129(18):1850-9. doi: 10.1161/CIRCULATIONAHA.113.005754. Epub 2014 Feb 19. Goodman SG, Wojdyla DM, Piccini JP, White HD, Paolini JF, Nessel CC, Berkowitz SD, Mahaffey KW, Patel MR, Sherwood MW, Becker RC, Halperin JL, Hacke W, Singer DE, Hankey GJ, Breithardt G, Fox KA, Califf RM; ROCKET AF Investigators. Factors associated with major bleeding events: insights from the ROCKET AF trial (rivaroxaban once-daily oral direct factor Xa inhibition compared with vitamin K antagonism for prevention of stroke and embolism trial in atrial fibrillation). J Am Coll Cardiol. 2014 Mar 11;63(9):891-900. doi: 10.1016/j.jacc.2013.11.013. Epub 2013 Dec 4. Mahaffey KW, Wojdyla D, Hankey GJ, White HD, Nessel CC, Piccini JP, Patel MR, Berkowitz SD, Becker RC, Halperin JL, Singer DE, Califf RM, Fox KA, Breithardt G, Hacke W. Clinical outcomes with rivaroxaban in patients transitioned from vitamin K antagonist therapy: a subgroup analysis of a randomized trial. Ann Intern Med. 2013 Jun 18;158(12):861-8. doi: 10.7326/0003-4819-158-12-201306180-00003. van Diepen S, Hellkamp AS, Patel MR, Becker RC, Breithardt G, Hacke W, Halperin JL, Hankey GJ, Nessel CC, Singer DE, Berkowitz SD, Califf RM, Fox KA, Mahaffey KW. Efficacy and safety of rivaroxaban in patients with heart failure and nonvalvular atrial fibrillation: insights from ROCKET AF. Circ Heart Fail. 2013 Jul;6(4):740-7. doi: 10.1161/CIRCHEARTFAILURE.113.000212. Epub 2013 May 30. Singer DE, Hellkamp AS, Piccini JP, Mahaffey KW, Lokhnygina Y, Pan G, Halperin JL, Becker RC, Breithardt G, Hankey GJ, Hacke W, Nessel CC, Patel MR, Califf RM, Fox KA; ROCKET AF Investigators. Impact of global geographic region on time in therapeutic range on warfarin anticoagulant therapy: data from the ROCKET AF clinical trial. J Am Heart Assoc. 2013 Feb 19;2(1):e000067. doi: 10.1161/JAHA.112.000067. Piccini JP, Stevens SR, Lokhnygina Y, Patel MR, Halperin JL, Singer DE, Hankey GJ, Hacke W, Becker RC, Nessel CC, Mahaffey KW, Fox KA, Califf RM, Breithardt G; ROCKET AF Steering Committee & Investigators. Outcomes after cardioversion and atrial fibrillation ablation in patients treated with rivaroxaban and warfarin in the ROCKET AF trial. J Am Coll Cardiol. 2013 May 14;61(19):1998-2006. doi: 10.1016/j.jacc.2013.02.025. Epub 2013 Mar 14. Piccini JP, Stevens SR, Chang Y, Singer DE, Lokhnygina Y, Go AS, Patel MR, Mahaffey KW, Halperin JL, Breithardt G, Hankey GJ, Hacke W, Becker RC, Nessel CC, Fox KA, Califf RM; ROCKET AF Steering Committee and Investigators. Renal dysfunction as a predictor of stroke and systemic embolism in patients with nonvalvular atrial fibrillation: validation of the R(2)CHADS(2) index in the ROCKET AF (Rivaroxaban Once-daily, oral, direct factor Xa inhibition Compared with vitamin K antagonism for prevention of stroke and Embolism Trial in Atrial Fibrillation) and ATRIA (AnTicoagulation and Risk factors In Atrial fibrillation) study cohorts. Circulation. 2013 Jan 15;127(2):224-32. doi: 10.1161/CIRCULATIONAHA.112.107128. Epub 2012 Dec 3. Hankey GJ, Patel MR, Stevens SR, Becker RC, Breithardt G, Carolei A, Diener HC, Donnan GA, Halperin JL, Mahaffey KW, Mas JL, Massaro A, Norrving B, Nessel CC, Paolini JF, Roine RO, Singer DE, Wong L, Califf RM, Fox KA, Hacke W; ROCKET AF Steering Committee Investigators. Rivaroxaban compared with warfarin in patients with atrial fibrillation and previous stroke or transient ischaemic attack: a subgroup analysis of ROCKET AF. Lancet Neurol. 2012 Apr;11(4):315-22. doi: 10.1016/S1474-4422(12)70042-X. Epub 2012 Mar 7. Patel MR, Mahaffey KW, Garg J, Pan G, Singer DE, Hacke W, Breithardt G, Halperin JL, Hankey GJ, Piccini JP, Becker RC, Nessel CC, Paolini JF, Berkowitz SD, Fox KA, Califf RM; ROCKET AF Investigators. Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. N Engl J Med. 2011 Sep 8;365(10):883-91. doi: 10.1056/NEJMoa1009638. Epub 2011 Aug 10. ROCKET AF Study Investigators. Rivaroxaban-once daily, oral, direct factor Xa inhibition compared with vitamin K antagonism for prevention of stroke and Embolism Trial in Atrial Fibrillation: rationale and design of the ROCKET AF study. Am Heart J. 2010 Mar;159(3):340-347.e1. doi: 10.1016/j.ahj.2009.11.025.
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Johnson & Johnson Pharmaceutical Research & Development, L.L. C. Clinical Trial
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