Please note that the copy function is not enabled for this field.
If you wish to
modify
existing outcomes, please copy and paste the current outcome text into the Update field.
LOGIN
CREATE ACCOUNT
LOGIN
CREATE ACCOUNT
MY TRIALS
REGISTER TRIAL
FAQs
HINTS AND TIPS
DEFINITIONS
Trial Review
The ANZCTR website will be unavailable from 1pm until 3pm (AEDT) on Wednesday the 30th of October for website maintenance. Please be sure to log out of the system in order to avoid any loss of data.
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been endorsed by the ANZCTR. Before participating in a study, talk to your health care provider and refer to this
information for consumers
Download to PDF
Trial details imported from ClinicalTrials.gov
For full trial details, please see the original record at
https://clinicaltrials.gov/study/NCT00153062
Registration number
NCT00153062
Ethics application status
Date submitted
9/09/2005
Date registered
12/09/2005
Date last updated
13/05/2014
Titles & IDs
Public title
PRoFESS - Prevention Regimen For Effectively Avoiding Second Strokes
Query!
Scientific title
PRoFESS - Prevention Regimen For Effectively Avoiding Second Strokes: A Double-blind, Active and Placebo Controlled Study of Aggrenox vs. Clopidogrel, With and Without Micardis
Query!
Secondary ID [1]
0
0
9.159
Query!
Universal Trial Number (UTN)
Query!
Trial acronym
Query!
Linked study record
Query!
Health condition
Health condition(s) or problem(s) studied:
Stroke
0
0
Query!
Condition category
Condition code
Stroke
0
0
0
0
Query!
Haemorrhagic
Query!
Stroke
0
0
0
0
Query!
Ischaemic
Query!
Intervention/exposure
Study type
Interventional
Query!
Description of intervention(s) / exposure
Treatment: Drugs - Aggrenox
Treatment: Drugs - Aggrenox
Treatment: Drugs - Clopidogrel placebo
Treatment: Drugs - Clopidogrel placebo
Treatment: Drugs - Micardis
Treatment: Drugs - Micardis
Treatment: Drugs - Aggrenox placebo
Treatment: Drugs - Aggrenox placebo
Treatment: Drugs - Clopidogrel
Treatment: Drugs - Clopidogrel
Treatment: Drugs - Micardis placebo
Treatment: Drugs - Micardis placebo
Placebo comparator: Aggrenox, Clopidogrel placebo, Micardis - Aggrenox (25mg/200mg) bid, clopidogrel placebo qd, Micardis (80mg) qd
Placebo comparator: Aggrenox placebo, clopidogrel,, Micardis - Clopidogrel (75mg) qd; Aggrenox placebo bid, Micardis (80mg) qd
Placebo comparator: Aggrenox, clop placebo, micardis placebo - Aggrenox (25mg/200mg) bid, clopidogrel placebo qd, Micardis placebo qd
Placebo comparator: Aggrenox plcebo, clop, micardis placebo - Clopidogrel (75mg) qd, Aggrenox placebo bid, Micardis placebo qd.
Treatment: Drugs: Aggrenox
25mg aspirin, 200 mg dipyridamole
Treatment: Drugs: Aggrenox
25mg aspirin, 200 mg dipyridamole
Treatment: Drugs: Clopidogrel placebo
placebo
Treatment: Drugs: Clopidogrel placebo
placebo
Treatment: Drugs: Micardis
80 mg micardis
Treatment: Drugs: Micardis
80 mg micardis
Treatment: Drugs: Aggrenox placebo
placebo
Treatment: Drugs: Aggrenox placebo
placebo
Treatment: Drugs: Clopidogrel
75 mg clopidogrel
Treatment: Drugs: Clopidogrel
75 mg clopidogrel
Treatment: Drugs: Micardis placebo
placebo
Treatment: Drugs: Micardis placebo
placebo
Query!
Intervention code [1]
0
0
Treatment: Drugs
Query!
Comparator / control treatment
Query!
Control group
Query!
Outcomes
Primary outcome [1]
0
0
Number of Patients With First Recurrent Stroke of Any Type, Fatal or Nonfatal (Antiplatelet Comparison Only)
Query!
Assessment method [1]
0
0
Query!
Timepoint [1]
0
0
time since randomization; follow-up period is 1.5 to 4.4 years
Query!
Primary outcome [2]
0
0
Number of Patients With First Recurrent Stroke of Any Type, Fatal or Nonfatal (Telmisartan vs. Placebo Only)
Query!
Assessment method [2]
0
0
Query!
Timepoint [2]
0
0
time since randomization; follow-up period is 1.5 to 4.4 years
Query!
Secondary outcome [1]
0
0
Composite Outcome of Stroke, Myocardial Infarction (MI), or Vascular Death (Antiplatelet Comparison Only)
Query!
Assessment method [1]
0
0
Number of patients with any of stroke, myocardial infarction, vascular death
Query!
Timepoint [1]
0
0
time since randomization; follow-up period is 1.5 to 4.4 years
Query!
Secondary outcome [2]
0
0
Composite Outcome of Stroke, Myocardial Infarction, Vascular Death, or New or Worsening Congestive Heart Failure (CHF) (Telmisartan vs. Placebo Only)
Query!
Assessment method [2]
0
0
Number of patients with any of stroke, myocardial infarction, vascular death, or new or worsening congestive heart failure
Query!
Timepoint [2]
0
0
time since randomization; follow-up period is 1.5 to 4.4 years
Query!
Secondary outcome [3]
0
0
Number of Patients With New Onset of Diabetes (Telmisartan vs. Placebo Only)
Query!
Assessment method [3]
0
0
Query!
Timepoint [3]
0
0
Randomization to final patient contact
Query!
Eligibility
Key inclusion criteria
Inclusion criteria:
Male or female subjects 55 year or older who have suffered an ischemic stroke within the past 90 days and who meet all other inclusion criteria. Include also patients of ages 50 - 54 years and/or 90 to 120 days after the qualifying stroke provided the patient has at least two of the following additional risk factors:
* Diabetes mellitus
* Hypertension (systolic BP ¿ 140 or diastolic BP ¿ 90)
* Smoker at time of qualifying stroke
* Obesity (BMI>30; BMI=weight (kg)/[height (m)]2)
* Previous vascular disease (stroke, MI, or peripheral arterial disease prior to qualifying stroke)
* End-organ-damage (retinopathy, LVH, or microalbuminuria)
* Hyperlipidemia
Query!
Minimum age
50
Years
Query!
Query!
Maximum age
No limit
Query!
Query!
Sex
Both males and females
Query!
Can healthy volunteers participate?
No
Query!
Key exclusion criteria
Exclusion criteria:
hemorrhagic stroke (must be ruled out by imaging);unable to give informed consent; known brain tumor, severe renal or hepatic insufficiency, current active peptic ulcer disease, severe coronary artery disease including unstable angina pectoris or an MI within the previous 3 months,or history of a hemostatic disorder or systemic bleeding ;hyperkalemia;uncorrected volume or sodium depletion; pre-stroke history of dementia;modified Rankin score greater than 4;qualifying stroke induced by surgical or cardiovascular procedure;uncontrolled hypertension at entry above 180/110 mmHg (goal BPs are lower); SBP 120 mmHg or less for hospitalized patients; currently taking an ARB and not able or willing to switch to alternative; required or planned continuing treatment with antithrombotics or anticoagulants including heparin or warfarin or non-study platelet inhibitors; syndrome of asthma, rhinitis and nasal polyps;scheduled for major surgery, carotid endarterectomy, or carotid angioplasty (4 weeks post surgery is allowed);unlikely to be released from hospital following the qualifying stroke or presence of a severe disability likely to lead to being bedridden or demented or a non-vascular disease or condition which makes it unlikely that the patient will survive to the end of the trial; history of thrombocytopenia or neutropenia.
Query!
Study design
Purpose of the study
Prevention
Query!
Allocation to intervention
Randomised controlled trial
Query!
Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures)
Query!
Methods used to generate the sequence in which subjects will be randomised (sequence generation)
Query!
Masking / blinding
Blinded (masking used)
Query!
Who is / are masked / blinded?
Query!
Query!
Query!
Query!
Intervention assignment
Parallel
Query!
Other design features
Query!
Phase
Phase 4
Query!
Type of endpoint/s
Query!
Statistical methods / analysis
Query!
Recruitment
Recruitment status
Completed
Query!
Data analysis
Query!
Reason for early stopping/withdrawal
Query!
Other reasons
Query!
Date of first participant enrolment
Anticipated
Query!
Actual
1/08/2003
Query!
Date of last participant enrolment
Anticipated
Query!
Actual
Query!
Date of last data collection
Anticipated
Query!
Actual
Query!
Sample size
Target
Query!
Accrual to date
Query!
Final
20332
Query!
Recruitment in Australia
Recruitment state(s)
NSW,QLD,SA,VIC
Query!
Recruitment hospital [1]
0
0
9.159.2444 Boehringer Ingelheim Investigational Site - Gosford
Query!
Recruitment hospital [2]
0
0
9.159.2449 Boehringer Ingelheim Investigational Site - New Lambton
Query!
Recruitment hospital [3]
0
0
9.159.2448 Boehringer Ingelheim Investigational Site - Westmead
Query!
Recruitment hospital [4]
0
0
9.159.2450 Boehringer Ingelheim Investigational Site - Herston
Query!
Recruitment hospital [5]
0
0
9.159.2452 Boehringer Ingelheim Investigational Site - Southport
Query!
Recruitment hospital [6]
0
0
9.159.2451 Boehringer Ingelheim Investigational Site - Bedford Park
Query!
Recruitment hospital [7]
0
0
9.159.2443 Boehringer Ingelheim Investigational Site - Box Hill
Query!
Recruitment hospital [8]
0
0
9.159.2447 Boehringer Ingelheim Investigational Site - Melbourne
Query!
Recruitment hospital [9]
0
0
9.159.2445 Boehringer Ingelheim Investigational Site - Parkville
Query!
Recruitment hospital [10]
0
0
9.159.2446 Boehringer Ingelheim Investigational Site - West Heidelberg
Query!
Recruitment postcode(s) [1]
0
0
- Gosford
Query!
Recruitment postcode(s) [2]
0
0
- New Lambton
Query!
Recruitment postcode(s) [3]
0
0
- Westmead
Query!
Recruitment postcode(s) [4]
0
0
- Herston
Query!
Recruitment postcode(s) [5]
0
0
- Southport
Query!
Recruitment postcode(s) [6]
0
0
- Bedford Park
Query!
Recruitment postcode(s) [7]
0
0
- Box Hill
Query!
Recruitment postcode(s) [8]
0
0
- Melbourne
Query!
Recruitment postcode(s) [9]
0
0
- Parkville
Query!
Recruitment postcode(s) [10]
0
0
- West Heidelberg
Query!
Recruitment outside Australia
Country [1]
0
0
United States of America
Query!
State/province [1]
0
0
Alabama
Query!
Country [2]
0
0
United States of America
Query!
State/province [2]
0
0
Arizona
Query!
Country [3]
0
0
United States of America
Query!
State/province [3]
0
0
Arkansas
Query!
Country [4]
0
0
United States of America
Query!
State/province [4]
0
0
California
Query!
Country [5]
0
0
United States of America
Query!
State/province [5]
0
0
Colorado
Query!
Country [6]
0
0
United States of America
Query!
State/province [6]
0
0
Connecticut
Query!
Country [7]
0
0
United States of America
Query!
State/province [7]
0
0
Delaware
Query!
Country [8]
0
0
United States of America
Query!
State/province [8]
0
0
District of Columbia
Query!
Country [9]
0
0
United States of America
Query!
State/province [9]
0
0
Florida
Query!
Country [10]
0
0
United States of America
Query!
State/province [10]
0
0
Georgia
Query!
Country [11]
0
0
United States of America
Query!
State/province [11]
0
0
Idaho
Query!
Country [12]
0
0
United States of America
Query!
State/province [12]
0
0
Illinois
Query!
Country [13]
0
0
United States of America
Query!
State/province [13]
0
0
Indiana
Query!
Country [14]
0
0
United States of America
Query!
State/province [14]
0
0
Iowa
Query!
Country [15]
0
0
United States of America
Query!
State/province [15]
0
0
Kansas
Query!
Country [16]
0
0
United States of America
Query!
State/province [16]
0
0
Kentucky
Query!
Country [17]
0
0
United States of America
Query!
State/province [17]
0
0
Louisiana
Query!
Country [18]
0
0
United States of America
Query!
State/province [18]
0
0
Maryland
Query!
Country [19]
0
0
United States of America
Query!
State/province [19]
0
0
Massachusetts
Query!
Country [20]
0
0
United States of America
Query!
State/province [20]
0
0
Michigan
Query!
Country [21]
0
0
United States of America
Query!
State/province [21]
0
0
Minnesota
Query!
Country [22]
0
0
United States of America
Query!
State/province [22]
0
0
Missouri
Query!
Country [23]
0
0
United States of America
Query!
State/province [23]
0
0
Montana
Query!
Country [24]
0
0
United States of America
Query!
State/province [24]
0
0
Nebraska
Query!
Country [25]
0
0
United States of America
Query!
State/province [25]
0
0
Nevada
Query!
Country [26]
0
0
United States of America
Query!
State/province [26]
0
0
New Jersey
Query!
Country [27]
0
0
United States of America
Query!
State/province [27]
0
0
New Mexico
Query!
Country [28]
0
0
United States of America
Query!
State/province [28]
0
0
New York
Query!
Country [29]
0
0
United States of America
Query!
State/province [29]
0
0
North Carolina
Query!
Country [30]
0
0
United States of America
Query!
State/province [30]
0
0
North Dakota
Query!
Country [31]
0
0
United States of America
Query!
State/province [31]
0
0
Ohio
Query!
Country [32]
0
0
United States of America
Query!
State/province [32]
0
0
Oklahoma
Query!
Country [33]
0
0
United States of America
Query!
State/province [33]
0
0
Oregon
Query!
Country [34]
0
0
United States of America
Query!
State/province [34]
0
0
Pennsylvania
Query!
Country [35]
0
0
United States of America
Query!
State/province [35]
0
0
Rhode Island
Query!
Country [36]
0
0
United States of America
Query!
State/province [36]
0
0
South Carolina
Query!
Country [37]
0
0
United States of America
Query!
State/province [37]
0
0
Tennessee
Query!
Country [38]
0
0
United States of America
Query!
State/province [38]
0
0
Texas
Query!
Country [39]
0
0
United States of America
Query!
State/province [39]
0
0
Utah
Query!
Country [40]
0
0
United States of America
Query!
State/province [40]
0
0
Virginia
Query!
Country [41]
0
0
United States of America
Query!
State/province [41]
0
0
Washington
Query!
Country [42]
0
0
United States of America
Query!
State/province [42]
0
0
West Virginia
Query!
Country [43]
0
0
United States of America
Query!
State/province [43]
0
0
Wisconsin
Query!
Country [44]
0
0
Argentina
Query!
State/province [44]
0
0
Capital Federal
Query!
Country [45]
0
0
Argentina
Query!
State/province [45]
0
0
Rosario, Sta. Fe
Query!
Country [46]
0
0
Argentina
Query!
State/province [46]
0
0
Santa Fe
Query!
Country [47]
0
0
Austria
Query!
State/province [47]
0
0
Graz
Query!
Country [48]
0
0
Austria
Query!
State/province [48]
0
0
Innsbruck
Query!
Country [49]
0
0
Austria
Query!
State/province [49]
0
0
Linz
Query!
Country [50]
0
0
Austria
Query!
State/province [50]
0
0
Ma.Gugging/Klosterneuburg
Query!
Country [51]
0
0
Austria
Query!
State/province [51]
0
0
St. Pölten
Query!
Country [52]
0
0
Austria
Query!
State/province [52]
0
0
Wien
Query!
Country [53]
0
0
Belgium
Query!
State/province [53]
0
0
Aalst
Query!
Country [54]
0
0
Belgium
Query!
State/province [54]
0
0
Anderlecht
Query!
Country [55]
0
0
Belgium
Query!
State/province [55]
0
0
Antwerpen
Query!
Country [56]
0
0
Belgium
Query!
State/province [56]
0
0
Bonheiden
Query!
Country [57]
0
0
Belgium
Query!
State/province [57]
0
0
Brugge
Query!
Country [58]
0
0
Belgium
Query!
State/province [58]
0
0
Bruxelles
Query!
Country [59]
0
0
Belgium
Query!
State/province [59]
0
0
Hasselt
Query!
Country [60]
0
0
Belgium
Query!
State/province [60]
0
0
Kortrijk
Query!
Country [61]
0
0
Belgium
Query!
State/province [61]
0
0
La Louvière
Query!
Country [62]
0
0
Belgium
Query!
State/province [62]
0
0
Leuven
Query!
Country [63]
0
0
Belgium
Query!
State/province [63]
0
0
Montegnée
Query!
Country [64]
0
0
Belgium
Query!
State/province [64]
0
0
Ottignies
Query!
Country [65]
0
0
Belgium
Query!
State/province [65]
0
0
Wilrijk
Query!
Country [66]
0
0
Belgium
Query!
State/province [66]
0
0
Yvoir
Query!
Country [67]
0
0
Brazil
Query!
State/province [67]
0
0
Salvador
Query!
Country [68]
0
0
Brazil
Query!
State/province [68]
0
0
São Paulo
Query!
Country [69]
0
0
Canada
Query!
State/province [69]
0
0
Alberta
Query!
Country [70]
0
0
Canada
Query!
State/province [70]
0
0
British Columbia
Query!
Country [71]
0
0
Canada
Query!
State/province [71]
0
0
Manitoba
Query!
Country [72]
0
0
Canada
Query!
State/province [72]
0
0
New Brunswick
Query!
Country [73]
0
0
Canada
Query!
State/province [73]
0
0
Newfoundland and Labrador
Query!
Country [74]
0
0
Canada
Query!
State/province [74]
0
0
Nova Scotia
Query!
Country [75]
0
0
Canada
Query!
State/province [75]
0
0
Ontario
Query!
Country [76]
0
0
Canada
Query!
State/province [76]
0
0
Quebec
Query!
Country [77]
0
0
Canada
Query!
State/province [77]
0
0
Saskatchewan
Query!
Country [78]
0
0
China
Query!
State/province [78]
0
0
Beijing
Query!
Country [79]
0
0
China
Query!
State/province [79]
0
0
Changchun, Jilin Province
Query!
Country [80]
0
0
China
Query!
State/province [80]
0
0
Changsha, Hunan Province
Query!
Country [81]
0
0
China
Query!
State/province [81]
0
0
Chengdu, Sichuan Province
Query!
Country [82]
0
0
China
Query!
State/province [82]
0
0
Chongqing
Query!
Country [83]
0
0
China
Query!
State/province [83]
0
0
Guangzhou, Guangdong Province
Query!
Country [84]
0
0
China
Query!
State/province [84]
0
0
Guangzhou
Query!
Country [85]
0
0
China
Query!
State/province [85]
0
0
Hangzhou, Zhejiang Province
Query!
Country [86]
0
0
China
Query!
State/province [86]
0
0
Harbin, Heilongjiang Province
Query!
Country [87]
0
0
China
Query!
State/province [87]
0
0
Jinan, Shandong Province
Query!
Country [88]
0
0
China
Query!
State/province [88]
0
0
Jinan, Shangdong Province
Query!
Country [89]
0
0
China
Query!
State/province [89]
0
0
Nanjing, Jiangsu Province
Query!
Country [90]
0
0
China
Query!
State/province [90]
0
0
Shanghai
Query!
Country [91]
0
0
China
Query!
State/province [91]
0
0
Suzhou, Jiangsu Province
Query!
Country [92]
0
0
China
Query!
State/province [92]
0
0
Tianjin
Query!
Country [93]
0
0
China
Query!
State/province [93]
0
0
Wenzhou, Zhejiang Province
Query!
Country [94]
0
0
China
Query!
State/province [94]
0
0
Wuhan, Hubei Province
Query!
Country [95]
0
0
China
Query!
State/province [95]
0
0
Xian, Shanxi Province
Query!
Country [96]
0
0
China
Query!
State/province [96]
0
0
Xian, Shanxi
Query!
Country [97]
0
0
China
Query!
State/province [97]
0
0
Xian
Query!
Country [98]
0
0
Denmark
Query!
State/province [98]
0
0
Aarhuc C
Query!
Country [99]
0
0
Denmark
Query!
State/province [99]
0
0
Aarhus C
Query!
Country [100]
0
0
Denmark
Query!
State/province [100]
0
0
Esbjerg
Query!
Country [101]
0
0
Denmark
Query!
State/province [101]
0
0
Frederiksberg
Query!
Country [102]
0
0
Denmark
Query!
State/province [102]
0
0
Glostrup
Query!
Country [103]
0
0
Denmark
Query!
State/province [103]
0
0
Hellerup
Query!
Country [104]
0
0
Denmark
Query!
State/province [104]
0
0
Hvidovre
Query!
Country [105]
0
0
Denmark
Query!
State/province [105]
0
0
København NV
Query!
Country [106]
0
0
Denmark
Query!
State/province [106]
0
0
København Ø
Query!
Country [107]
0
0
Denmark
Query!
State/province [107]
0
0
Odense
Query!
Country [108]
0
0
El Salvador
Query!
State/province [108]
0
0
Oviedo
Query!
Country [109]
0
0
Finland
Query!
State/province [109]
0
0
Helsinki
Query!
Country [110]
0
0
Finland
Query!
State/province [110]
0
0
Kuopio
Query!
Country [111]
0
0
Finland
Query!
State/province [111]
0
0
Lappeenranta
Query!
Country [112]
0
0
Finland
Query!
State/province [112]
0
0
Oulu
Query!
Country [113]
0
0
Finland
Query!
State/province [113]
0
0
Seinäjoki
Query!
Country [114]
0
0
France
Query!
State/province [114]
0
0
Lille cedex
Query!
Country [115]
0
0
France
Query!
State/province [115]
0
0
Limoges cedex 1
Query!
Country [116]
0
0
France
Query!
State/province [116]
0
0
Marseille cedex 05
Query!
Country [117]
0
0
France
Query!
State/province [117]
0
0
Nancy
Query!
Country [118]
0
0
France
Query!
State/province [118]
0
0
Paris cedex 19
Query!
Country [119]
0
0
France
Query!
State/province [119]
0
0
Poitiers cedex
Query!
Country [120]
0
0
France
Query!
State/province [120]
0
0
Tours cedex 9
Query!
Country [121]
0
0
Germany
Query!
State/province [121]
0
0
Bad Neustadt/Saale
Query!
Country [122]
0
0
Germany
Query!
State/province [122]
0
0
Berlin
Query!
Country [123]
0
0
Germany
Query!
State/province [123]
0
0
Braunschweig
Query!
Country [124]
0
0
Germany
Query!
State/province [124]
0
0
Cloppenburg
Query!
Country [125]
0
0
Germany
Query!
State/province [125]
0
0
Dresden
Query!
Country [126]
0
0
Germany
Query!
State/province [126]
0
0
Düsseldorf
Query!
Country [127]
0
0
Germany
Query!
State/province [127]
0
0
Essen
Query!
Country [128]
0
0
Germany
Query!
State/province [128]
0
0
Freiburg
Query!
Country [129]
0
0
Germany
Query!
State/province [129]
0
0
Gießen
Query!
Country [130]
0
0
Germany
Query!
State/province [130]
0
0
Hamburg
Query!
Country [131]
0
0
Germany
Query!
State/province [131]
0
0
Heidelberg
Query!
Country [132]
0
0
Germany
Query!
State/province [132]
0
0
Jena
Query!
Country [133]
0
0
Germany
Query!
State/province [133]
0
0
Kaiserslautern
Query!
Country [134]
0
0
Germany
Query!
State/province [134]
0
0
Köln
Query!
Country [135]
0
0
Germany
Query!
State/province [135]
0
0
Leipzig
Query!
Country [136]
0
0
Germany
Query!
State/province [136]
0
0
Ludwigshafen am Rhein
Query!
Country [137]
0
0
Germany
Query!
State/province [137]
0
0
Magdeburg
Query!
Country [138]
0
0
Germany
Query!
State/province [138]
0
0
Mainz
Query!
Country [139]
0
0
Germany
Query!
State/province [139]
0
0
Minden
Query!
Country [140]
0
0
Germany
Query!
State/province [140]
0
0
Mönchengladbach
Query!
Country [141]
0
0
Germany
Query!
State/province [141]
0
0
München
Query!
Country [142]
0
0
Germany
Query!
State/province [142]
0
0
Münster
Query!
Country [143]
0
0
Germany
Query!
State/province [143]
0
0
Nürnberg
Query!
Country [144]
0
0
Germany
Query!
State/province [144]
0
0
Regensburg
Query!
Country [145]
0
0
Germany
Query!
State/province [145]
0
0
Remscheid
Query!
Country [146]
0
0
Germany
Query!
State/province [146]
0
0
Rostock
Query!
Country [147]
0
0
Germany
Query!
State/province [147]
0
0
Saarbrücken
Query!
Country [148]
0
0
Germany
Query!
State/province [148]
0
0
Siegen
Query!
Country [149]
0
0
Germany
Query!
State/province [149]
0
0
Stuttgart
Query!
Country [150]
0
0
Germany
Query!
State/province [150]
0
0
Weimar
Query!
Country [151]
0
0
Greece
Query!
State/province [151]
0
0
Alexandroupolis
Query!
Country [152]
0
0
Greece
Query!
State/province [152]
0
0
Athens
Query!
Country [153]
0
0
Greece
Query!
State/province [153]
0
0
Ioannina
Query!
Country [154]
0
0
Greece
Query!
State/province [154]
0
0
Patras
Query!
Country [155]
0
0
Hong Kong
Query!
State/province [155]
0
0
Hong KoNG
Query!
Country [156]
0
0
Hong Kong
Query!
State/province [156]
0
0
Hong Kong
Query!
Country [157]
0
0
India
Query!
State/province [157]
0
0
Annamalainagar
Query!
Country [158]
0
0
India
Query!
State/province [158]
0
0
Bangalore
Query!
Country [159]
0
0
India
Query!
State/province [159]
0
0
Bikaner
Query!
Country [160]
0
0
India
Query!
State/province [160]
0
0
Calicut
Query!
Country [161]
0
0
India
Query!
State/province [161]
0
0
Chennai
Query!
Country [162]
0
0
India
Query!
State/province [162]
0
0
Cochin
Query!
Country [163]
0
0
India
Query!
State/province [163]
0
0
Hyderabad
Query!
Country [164]
0
0
India
Query!
State/province [164]
0
0
Indore
Query!
Country [165]
0
0
India
Query!
State/province [165]
0
0
Jaipur
Query!
Country [166]
0
0
India
Query!
State/province [166]
0
0
Jodhpur
Query!
Country [167]
0
0
India
Query!
State/province [167]
0
0
Kottayam
Query!
Country [168]
0
0
India
Query!
State/province [168]
0
0
Lucknow
Query!
Country [169]
0
0
India
Query!
State/province [169]
0
0
Ludhiana
Query!
Country [170]
0
0
India
Query!
State/province [170]
0
0
Mumbai
Query!
Country [171]
0
0
India
Query!
State/province [171]
0
0
New Delhi
Query!
Country [172]
0
0
India
Query!
State/province [172]
0
0
Patiala
Query!
Country [173]
0
0
India
Query!
State/province [173]
0
0
Pune
Query!
Country [174]
0
0
India
Query!
State/province [174]
0
0
Secunderabad
Query!
Country [175]
0
0
India
Query!
State/province [175]
0
0
Trichy
Query!
Country [176]
0
0
India
Query!
State/province [176]
0
0
Visakhapatnam
Query!
Country [177]
0
0
India
Query!
State/province [177]
0
0
Wardha
Query!
Country [178]
0
0
Ireland
Query!
State/province [178]
0
0
Cork
Query!
Country [179]
0
0
Ireland
Query!
State/province [179]
0
0
Dublin 7
Query!
Country [180]
0
0
Israel
Query!
State/province [180]
0
0
Ashkelon
Query!
Country [181]
0
0
Israel
Query!
State/province [181]
0
0
Haifa
Query!
Country [182]
0
0
Israel
Query!
State/province [182]
0
0
Israel
Query!
Country [183]
0
0
Israel
Query!
State/province [183]
0
0
Naharia
Query!
Country [184]
0
0
Israel
Query!
State/province [184]
0
0
Petach Tikva
Query!
Country [185]
0
0
Israel
Query!
State/province [185]
0
0
Tel Hashomer
Query!
Country [186]
0
0
Israel
Query!
State/province [186]
0
0
Tel-Aviv
Query!
Country [187]
0
0
Italy
Query!
State/province [187]
0
0
Ancona
Query!
Country [188]
0
0
Italy
Query!
State/province [188]
0
0
Cagliari
Query!
Country [189]
0
0
Italy
Query!
State/province [189]
0
0
Como
Query!
Country [190]
0
0
Italy
Query!
State/province [190]
0
0
Firenze
Query!
Country [191]
0
0
Italy
Query!
State/province [191]
0
0
Genova
Query!
Country [192]
0
0
Italy
Query!
State/province [192]
0
0
Jesi (ancona)
Query!
Country [193]
0
0
Italy
Query!
State/province [193]
0
0
L'aquila
Query!
Country [194]
0
0
Italy
Query!
State/province [194]
0
0
Milano
Query!
Country [195]
0
0
Italy
Query!
State/province [195]
0
0
Napoli
Query!
Country [196]
0
0
Italy
Query!
State/province [196]
0
0
Padova
Query!
Country [197]
0
0
Italy
Query!
State/province [197]
0
0
Palermo
Query!
Country [198]
0
0
Italy
Query!
State/province [198]
0
0
Pozzilli (IS)
Query!
Country [199]
0
0
Italy
Query!
State/province [199]
0
0
Roma
Query!
Country [200]
0
0
Italy
Query!
State/province [200]
0
0
Siracusa
Query!
Country [201]
0
0
Italy
Query!
State/province [201]
0
0
Terni
Query!
Country [202]
0
0
Italy
Query!
State/province [202]
0
0
Torino
Query!
Country [203]
0
0
Italy
Query!
State/province [203]
0
0
Trieste
Query!
Country [204]
0
0
Italy
Query!
State/province [204]
0
0
Vibo Valentia
Query!
Country [205]
0
0
Italy
Query!
State/province [205]
0
0
Vicenza
Query!
Country [206]
0
0
Japan
Query!
State/province [206]
0
0
Adachi-ku, Tokyo
Query!
Country [207]
0
0
Japan
Query!
State/province [207]
0
0
Akashi, Hyogo
Query!
Country [208]
0
0
Japan
Query!
State/province [208]
0
0
Ako, Hyogo
Query!
Country [209]
0
0
Japan
Query!
State/province [209]
0
0
Aoba-ku, Yokohama, Kanagawa
Query!
Country [210]
0
0
Japan
Query!
State/province [210]
0
0
Azumino, Nagano
Query!
Country [211]
0
0
Japan
Query!
State/province [211]
0
0
Chitose, Hokkaido
Query!
Country [212]
0
0
Japan
Query!
State/province [212]
0
0
Chuo-ku, Kobe, Hyogo
Query!
Country [213]
0
0
Japan
Query!
State/province [213]
0
0
Chuo-Ku, Sapporo, Hokkaido
Query!
Country [214]
0
0
Japan
Query!
State/province [214]
0
0
Fushimi-ku, Kyoto, Kyoto
Query!
Country [215]
0
0
Japan
Query!
State/province [215]
0
0
Habikino, Osaka
Query!
Country [216]
0
0
Japan
Query!
State/province [216]
0
0
Higashi-ku, Sapporo, Hokkaido
Query!
Country [217]
0
0
Japan
Query!
State/province [217]
0
0
Higashi-osaka, Osaka
Query!
Country [218]
0
0
Japan
Query!
State/province [218]
0
0
Higashinari-ku, Osaka, Osaka
Query!
Country [219]
0
0
Japan
Query!
State/province [219]
0
0
Higashiyodogawa-ku, Osaka, Osaka
Query!
Country [220]
0
0
Japan
Query!
State/province [220]
0
0
Hitachinaka, Ibaraki
Query!
Country [221]
0
0
Japan
Query!
State/province [221]
0
0
Iida, Nagano
Query!
Country [222]
0
0
Japan
Query!
State/province [222]
0
0
Izumisano, Osaka
Query!
Country [223]
0
0
Japan
Query!
State/province [223]
0
0
Jyonan-ku, Fukuoka, Fukuoka
Query!
Country [224]
0
0
Japan
Query!
State/province [224]
0
0
Kasama, Ibaraki
Query!
Country [225]
0
0
Japan
Query!
State/province [225]
0
0
Kasuga, Fukuoka
Query!
Country [226]
0
0
Japan
Query!
State/province [226]
0
0
Kita-ku, Osaka, Osaka
Query!
Country [227]
0
0
Japan
Query!
State/province [227]
0
0
Koriyama, Fukushima
Query!
Country [228]
0
0
Japan
Query!
State/province [228]
0
0
Kushiro, Hokkaido
Query!
Country [229]
0
0
Japan
Query!
State/province [229]
0
0
Matsumoto, Nagano
Query!
Country [230]
0
0
Japan
Query!
State/province [230]
0
0
Midori-ku, Yokohama, Kanagawa
Query!
Country [231]
0
0
Japan
Query!
State/province [231]
0
0
Moriya, Ibaraki
Query!
Country [232]
0
0
Japan
Query!
State/province [232]
0
0
Musashino, Tokyo
Query!
Country [233]
0
0
Japan
Query!
State/province [233]
0
0
Nakagawa-ku, Nagoya, Aichi
Query!
Country [234]
0
0
Japan
Query!
State/province [234]
0
0
Nishi-yodogawa-ku, Osaka, Osaka
Query!
Country [235]
0
0
Japan
Query!
State/province [235]
0
0
Ohnojo, Fukuoka
Query!
Country [236]
0
0
Japan
Query!
State/province [236]
0
0
Sakai-ku, Sakai, Osaka
Query!
Country [237]
0
0
Japan
Query!
State/province [237]
0
0
Sawara-ku, Fukuoka, Fukuoka
Query!
Country [238]
0
0
Japan
Query!
State/province [238]
0
0
Shimogyo-ku, Kyoto, Kyoto
Query!
Country [239]
0
0
Japan
Query!
State/province [239]
0
0
Shiroishi, Miyagi
Query!
Country [240]
0
0
Japan
Query!
State/province [240]
0
0
Suwa, Nagano
Query!
Country [241]
0
0
Japan
Query!
State/province [241]
0
0
Takikawa, Hokkaido
Query!
Country [242]
0
0
Japan
Query!
State/province [242]
0
0
Tatebayashi, Gunma
Query!
Country [243]
0
0
Japan
Query!
State/province [243]
0
0
Tsuchiura, Ibaraki
Query!
Country [244]
0
0
Japan
Query!
State/province [244]
0
0
Yao, Osaka
Query!
Country [245]
0
0
Korea, Republic of
Query!
State/province [245]
0
0
Gwangju
Query!
Country [246]
0
0
Korea, Republic of
Query!
State/province [246]
0
0
Incheon
Query!
Country [247]
0
0
Korea, Republic of
Query!
State/province [247]
0
0
Kyunggi-do
Query!
Country [248]
0
0
Korea, Republic of
Query!
State/province [248]
0
0
Seoul
Query!
Country [249]
0
0
Korea, Republic of
Query!
State/province [249]
0
0
Suwon
Query!
Country [250]
0
0
Malaysia
Query!
State/province [250]
0
0
Kelantan Darul Naim
Query!
Country [251]
0
0
Malaysia
Query!
State/province [251]
0
0
Kuala Lumpur
Query!
Country [252]
0
0
Mexico
Query!
State/province [252]
0
0
Metepec
Query!
Country [253]
0
0
Netherlands
Query!
State/province [253]
0
0
's-Hertogenbosch
Query!
Country [254]
0
0
Netherlands
Query!
State/province [254]
0
0
Alkmaar
Query!
Country [255]
0
0
Netherlands
Query!
State/province [255]
0
0
Assen
Query!
Country [256]
0
0
Netherlands
Query!
State/province [256]
0
0
Blaricum
Query!
Country [257]
0
0
Netherlands
Query!
State/province [257]
0
0
Breda
Query!
Country [258]
0
0
Netherlands
Query!
State/province [258]
0
0
Den Haag
Query!
Country [259]
0
0
Netherlands
Query!
State/province [259]
0
0
Eindhoven
Query!
Country [260]
0
0
Netherlands
Query!
State/province [260]
0
0
Emmen
Query!
Country [261]
0
0
Netherlands
Query!
State/province [261]
0
0
Enschede
Query!
Country [262]
0
0
Netherlands
Query!
State/province [262]
0
0
Groningen
Query!
Country [263]
0
0
Netherlands
Query!
State/province [263]
0
0
Heerlen
Query!
Country [264]
0
0
Netherlands
Query!
State/province [264]
0
0
Helmond
Query!
Country [265]
0
0
Netherlands
Query!
State/province [265]
0
0
Hengelo
Query!
Country [266]
0
0
Netherlands
Query!
State/province [266]
0
0
Leeuwarden
Query!
Country [267]
0
0
Netherlands
Query!
State/province [267]
0
0
Leiderdorp
Query!
Country [268]
0
0
Netherlands
Query!
State/province [268]
0
0
Nieuwegein
Query!
Country [269]
0
0
Netherlands
Query!
State/province [269]
0
0
Nijmegen
Query!
Country [270]
0
0
Netherlands
Query!
State/province [270]
0
0
Tilburg
Query!
Country [271]
0
0
Netherlands
Query!
State/province [271]
0
0
Veldhoven
Query!
Country [272]
0
0
Netherlands
Query!
State/province [272]
0
0
Weert
Query!
Country [273]
0
0
Norway
Query!
State/province [273]
0
0
Bergen
Query!
Country [274]
0
0
Norway
Query!
State/province [274]
0
0
Oslo
Query!
Country [275]
0
0
Norway
Query!
State/province [275]
0
0
Trondheim
Query!
Country [276]
0
0
Portugal
Query!
State/province [276]
0
0
Amadora
Query!
Country [277]
0
0
Portugal
Query!
State/province [277]
0
0
Coimbra
Query!
Country [278]
0
0
Portugal
Query!
State/province [278]
0
0
Lisboa
Query!
Country [279]
0
0
Portugal
Query!
State/province [279]
0
0
Porto
Query!
Country [280]
0
0
Russian Federation
Query!
State/province [280]
0
0
Ekaterinburg
Query!
Country [281]
0
0
Russian Federation
Query!
State/province [281]
0
0
Kazan
Query!
Country [282]
0
0
Russian Federation
Query!
State/province [282]
0
0
Kemerovo
Query!
Country [283]
0
0
Russian Federation
Query!
State/province [283]
0
0
Kirov
Query!
Country [284]
0
0
Russian Federation
Query!
State/province [284]
0
0
Krasnoyarsk
Query!
Country [285]
0
0
Russian Federation
Query!
State/province [285]
0
0
Moscow
Query!
Country [286]
0
0
Russian Federation
Query!
State/province [286]
0
0
Nizhnyi Novgorod
Query!
Country [287]
0
0
Russian Federation
Query!
State/province [287]
0
0
Novosibirsk
Query!
Country [288]
0
0
Russian Federation
Query!
State/province [288]
0
0
Omsk
Query!
Country [289]
0
0
Russian Federation
Query!
State/province [289]
0
0
Orel
Query!
Country [290]
0
0
Russian Federation
Query!
State/province [290]
0
0
Rostov-na-Donu
Query!
Country [291]
0
0
Russian Federation
Query!
State/province [291]
0
0
Samara
Query!
Country [292]
0
0
Russian Federation
Query!
State/province [292]
0
0
Saratov
Query!
Country [293]
0
0
Russian Federation
Query!
State/province [293]
0
0
Seversk
Query!
Country [294]
0
0
Russian Federation
Query!
State/province [294]
0
0
Smolensk
Query!
Country [295]
0
0
Russian Federation
Query!
State/province [295]
0
0
St. Petersburg
Query!
Country [296]
0
0
Russian Federation
Query!
State/province [296]
0
0
Ufa
Query!
Country [297]
0
0
Russian Federation
Query!
State/province [297]
0
0
Volgograd
Query!
Country [298]
0
0
Russian Federation
Query!
State/province [298]
0
0
Voronezh
Query!
Country [299]
0
0
Russian Federation
Query!
State/province [299]
0
0
Yaroslavl
Query!
Country [300]
0
0
Singapore
Query!
State/province [300]
0
0
Singapore
Query!
Country [301]
0
0
South Africa
Query!
State/province [301]
0
0
Bloemfontein
Query!
Country [302]
0
0
South Africa
Query!
State/province [302]
0
0
Cape Town
Query!
Country [303]
0
0
South Africa
Query!
State/province [303]
0
0
Durban
Query!
Country [304]
0
0
South Africa
Query!
State/province [304]
0
0
Johannesburg
Query!
Country [305]
0
0
South Africa
Query!
State/province [305]
0
0
Pretoria
Query!
Country [306]
0
0
South Africa
Query!
State/province [306]
0
0
Sunninghill
Query!
Country [307]
0
0
Spain
Query!
State/province [307]
0
0
Alicante
Query!
Country [308]
0
0
Spain
Query!
State/province [308]
0
0
Barcelona
Query!
Country [309]
0
0
Spain
Query!
State/province [309]
0
0
Hospitalet de Llobregat (Barcelona)
Query!
Country [310]
0
0
Spain
Query!
State/province [310]
0
0
Madrid
Query!
Country [311]
0
0
Spain
Query!
State/province [311]
0
0
Pamplona
Query!
Country [312]
0
0
Sweden
Query!
State/province [312]
0
0
Borås
Query!
Country [313]
0
0
Sweden
Query!
State/province [313]
0
0
Eskilstuna
Query!
Country [314]
0
0
Sweden
Query!
State/province [314]
0
0
Göteborg
Query!
Country [315]
0
0
Sweden
Query!
State/province [315]
0
0
Holon
Query!
Country [316]
0
0
Sweden
Query!
State/province [316]
0
0
Jönköping
Query!
Country [317]
0
0
Sweden
Query!
State/province [317]
0
0
Lund
Query!
Country [318]
0
0
Sweden
Query!
State/province [318]
0
0
Mora
Query!
Country [319]
0
0
Sweden
Query!
State/province [319]
0
0
Skellefteå
Query!
Country [320]
0
0
Sweden
Query!
State/province [320]
0
0
Skövde
Query!
Country [321]
0
0
Sweden
Query!
State/province [321]
0
0
Stockholm
Query!
Country [322]
0
0
Sweden
Query!
State/province [322]
0
0
Umeå
Query!
Country [323]
0
0
Sweden
Query!
State/province [323]
0
0
Värnamo
Query!
Country [324]
0
0
Sweden
Query!
State/province [324]
0
0
Västervik
Query!
Country [325]
0
0
Sweden
Query!
State/province [325]
0
0
Örebro
Query!
Country [326]
0
0
Taiwan
Query!
State/province [326]
0
0
Kaohsiung
Query!
Country [327]
0
0
Taiwan
Query!
State/province [327]
0
0
Taichung
Query!
Country [328]
0
0
Taiwan
Query!
State/province [328]
0
0
Tainan
Query!
Country [329]
0
0
Taiwan
Query!
State/province [329]
0
0
Taipei
Query!
Country [330]
0
0
Taiwan
Query!
State/province [330]
0
0
Taoyuan
Query!
Country [331]
0
0
Thailand
Query!
State/province [331]
0
0
Bangkok
Query!
Country [332]
0
0
Thailand
Query!
State/province [332]
0
0
Chiang Mai
Query!
Country [333]
0
0
Turkey
Query!
State/province [333]
0
0
Ankara
Query!
Country [334]
0
0
Turkey
Query!
State/province [334]
0
0
Antalya
Query!
Country [335]
0
0
Turkey
Query!
State/province [335]
0
0
Bursa
Query!
Country [336]
0
0
Turkey
Query!
State/province [336]
0
0
Eskisehir
Query!
Country [337]
0
0
Turkey
Query!
State/province [337]
0
0
Istanbul
Query!
Country [338]
0
0
Turkey
Query!
State/province [338]
0
0
Izmir
Query!
Country [339]
0
0
Ukraine
Query!
State/province [339]
0
0
Dnepropetrovsk
Query!
Country [340]
0
0
Ukraine
Query!
State/province [340]
0
0
Kharkiv
Query!
Country [341]
0
0
Ukraine
Query!
State/province [341]
0
0
Kyiv
Query!
Country [342]
0
0
Ukraine
Query!
State/province [342]
0
0
Odesa
Query!
Country [343]
0
0
Ukraine
Query!
State/province [343]
0
0
Vinnytzya
Query!
Country [344]
0
0
Ukraine
Query!
State/province [344]
0
0
Zaporizhzhya
Query!
Country [345]
0
0
United Kingdom
Query!
State/province [345]
0
0
Belfast
Query!
Country [346]
0
0
United Kingdom
Query!
State/province [346]
0
0
Birmingham
Query!
Country [347]
0
0
United Kingdom
Query!
State/province [347]
0
0
Bournemouth
Query!
Country [348]
0
0
United Kingdom
Query!
State/province [348]
0
0
Bristol
Query!
Country [349]
0
0
United Kingdom
Query!
State/province [349]
0
0
Dundee
Query!
Country [350]
0
0
United Kingdom
Query!
State/province [350]
0
0
Exeter
Query!
Country [351]
0
0
United Kingdom
Query!
State/province [351]
0
0
Glasgow
Query!
Country [352]
0
0
United Kingdom
Query!
State/province [352]
0
0
Harrow
Query!
Country [353]
0
0
United Kingdom
Query!
State/province [353]
0
0
Henshingham, Whitehaven
Query!
Country [354]
0
0
United Kingdom
Query!
State/province [354]
0
0
Leicester
Query!
Country [355]
0
0
United Kingdom
Query!
State/province [355]
0
0
Liverpool
Query!
Country [356]
0
0
United Kingdom
Query!
State/province [356]
0
0
London
Query!
Country [357]
0
0
United Kingdom
Query!
State/province [357]
0
0
Mansfield
Query!
Country [358]
0
0
United Kingdom
Query!
State/province [358]
0
0
Newcastle Upon Tyne
Query!
Country [359]
0
0
United Kingdom
Query!
State/province [359]
0
0
North Shields
Query!
Country [360]
0
0
United Kingdom
Query!
State/province [360]
0
0
Northampton
Query!
Country [361]
0
0
United Kingdom
Query!
State/province [361]
0
0
Nottingham
Query!
Country [362]
0
0
United Kingdom
Query!
State/province [362]
0
0
Poole
Query!
Country [363]
0
0
United Kingdom
Query!
State/province [363]
0
0
Rotherham
Query!
Country [364]
0
0
United Kingdom
Query!
State/province [364]
0
0
Sheffield
Query!
Country [365]
0
0
United Kingdom
Query!
State/province [365]
0
0
Southampton
Query!
Country [366]
0
0
United Kingdom
Query!
State/province [366]
0
0
Stoke on Trent
Query!
Country [367]
0
0
United Kingdom
Query!
State/province [367]
0
0
Sunderland
Query!
Funding & Sponsors
Primary sponsor type
Commercial sector/industry
Query!
Name
Boehringer Ingelheim
Query!
Address
Query!
Country
Query!
Other collaborator category [1]
0
0
Commercial sector/industry
Query!
Name [1]
0
0
GlaxoSmithKline
Query!
Address [1]
0
0
Query!
Country [1]
0
0
Query!
Other collaborator category [2]
0
0
Commercial sector/industry
Query!
Name [2]
0
0
Bayer
Query!
Address [2]
0
0
Query!
Country [2]
0
0
Query!
Ethics approval
Ethics application status
Query!
Summary
Brief summary
The purpose of the trial is to determine if extended-release dipyridamole + aspirin \[Aggrenox, Asasa ntin\] is superior to clopidogrel \[Plavix\], and if telmisartan \[Micardis, Gliosartan, Kinzal, Kinzalm ono, Predxal, Pritor, Samertan, Telmisartan\] is superior to placebo, in the presence of background antihypertensive therapy, in prevention of a second stroke in patients who have recently suffered a stroke and therefore are at high risk of suffering another one.
Query!
Trial website
https://clinicaltrials.gov/study/NCT00153062
Query!
Trial related presentations / publications
Ovbiagele B, Bath PM, Cotton D, Sha N, Diener HC; PRoFESS Investigators. Low glomerular filtration rate, recurrent stroke risk, and effect of renin-angiotensin system modulation. Stroke. 2013 Nov;44(11):3223-5. doi: 10.1161/STROKEAHA.113.002463. Epub 2013 Aug 29. Bohm M, Cotton D, Foster L, Custodis F, Laufs U, Sacco R, Bath PM, Yusuf S, Diener HC. Impact of resting heart rate on mortality, disability and cognitive decline in patients after ischaemic stroke. Eur Heart J. 2012 Nov;33(22):2804-12. doi: 10.1093/eurheartj/ehs250. Epub 2012 Aug 26. Weber R, Weimar C, Blatchford J, Hermansson K, Wanke I, Moller-Hartmann C, Gizewski ER, Forsting M, Demchuk AM, Sacco RL, Saver JL, Warach S, Diener HC, Diehl A; PRoFESS Imaging Substudy Group. Telmisartan on top of antihypertensive treatment does not prevent progression of cerebral white matter lesions in the prevention regimen for effectively avoiding second strokes (PRoFESS) MRI substudy. Stroke. 2012 Sep;43(9):2336-42. doi: 10.1161/STROKEAHA.111.648576. Epub 2012 Jun 26. Weber R, Weimar C, Wanke I, Moller-Hartmann C, Gizewski ER, Blatchford J, Hermansson K, Demchuk AM, Forsting M, Sacco RL, Saver JL, Warach S, Diener HC, Diehl A; PRoFESS Imaging Substudy Group. Risk of recurrent stroke in patients with silent brain infarction in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) imaging substudy. Stroke. 2012 Feb;43(2):350-5. doi: 10.1161/STROKEAHA.111.631739. Epub 2012 Jan 19. Ovbiagele B, Diener HC, Yusuf S, Martin RH, Cotton D, Vinisko R, Donnan GA, Bath PM; PROFESS Investigators. Level of systolic blood pressure within the normal range and risk of recurrent stroke. JAMA. 2011 Nov 16;306(19):2137-44. doi: 10.1001/jama.2011.1650. Diener HC, Sacco RL, Yusuf S, Cotton D, Ounpuu S, Lawton WA, Palesch Y, Martin RH, Albers GW, Bath P, Bornstein N, Chan BP, Chen ST, Cunha L, Dahlof B, De Keyser J, Donnan GA, Estol C, Gorelick P, Gu V, Hermansson K, Hilbrich L, Kaste M, Lu C, Machnig T, Pais P, Roberts R, Skvortsova V, Teal P, Toni D, VanderMaelen C, Voigt T, Weber M, Yoon BW; Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) study group. Effects of aspirin plus extended-release dipyridamole versus clopidogrel and telmisartan on disability and cognitive function after recurrent stroke in patients with ischaemic stroke in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial: a double-blind, active and placebo-controlled study. Lancet Neurol. 2008 Oct;7(10):875-84. doi: 10.1016/S1474-4422(08)70198-4. Epub 2008 Aug 29. Erratum In: Lancet Neurol. 2008 Nov;7(11):985. Yusuf S, Diener HC, Sacco RL, Cotton D, Ounpuu S, Lawton WA, Palesch Y, Martin RH, Albers GW, Bath P, Bornstein N, Chan BP, Chen ST, Cunha L, Dahlof B, De Keyser J, Donnan GA, Estol C, Gorelick P, Gu V, Hermansson K, Hilbrich L, Kaste M, Lu C, Machnig T, Pais P, Roberts R, Skvortsova V, Teal P, Toni D, VanderMaelen C, Voigt T, Weber M, Yoon BW; PRoFESS Study Group. Telmisartan to prevent recurrent stroke and cardiovascular events. N Engl J Med. 2008 Sep 18;359(12):1225-37. doi: 10.1056/NEJMoa0804593. Epub 2008 Aug 27. Sacco RL, Diener HC, Yusuf S, Cotton D, Ounpuu S, Lawton WA, Palesch Y, Martin RH, Albers GW, Bath P, Bornstein N, Chan BP, Chen ST, Cunha L, Dahlof B, De Keyser J, Donnan GA, Estol C, Gorelick P, Gu V, Hermansson K, Hilbrich L, Kaste M, Lu C, Machnig T, Pais P, Roberts R, Skvortsova V, Teal P, Toni D, Vandermaelen C, Voigt T, Weber M, Yoon BW; PRoFESS Study Group. Aspirin and extended-release dipyridamole versus clopidogrel for recurrent stroke. N Engl J Med. 2008 Sep 18;359(12):1238-51. doi: 10.1056/NEJMoa0805002. Epub 2008 Aug 27.
Query!
Public notes
Query!
Contacts
Principal investigator
Name
0
0
Boehringer Ingelheim
Query!
Address
0
0
Boehringer Ingelheim
Query!
Country
0
0
Query!
Phone
0
0
Query!
Fax
0
0
Query!
Email
0
0
Query!
Contact person for public queries
Name
0
0
Query!
Address
0
0
Query!
Country
0
0
Query!
Phone
0
0
Query!
Fax
0
0
Query!
Email
0
0
Query!
Contact person for scientific queries
No information has been provided regarding IPD availability
What supporting documents are/will be available?
No Supporting Document Provided
Results publications and other study-related documents
No documents have been uploaded by study researchers.
Results are available at
https://clinicaltrials.gov/study/NCT00153062
Download to PDF